Neurology：芬戈莫德治疗导致的进行性多灶性白质脑病风险极低

2018-04-20 zhangfan MedSci原创

研究认为，对于未接受过那他珠单抗治疗的患者，接受芬戈莫德导致的进行性多灶性白质脑病风险极低，每1000患者的发病率为0.069，每100000患者年发病3.12例

近日研究人员就15名接受芬戈莫德治疗后出现进行性多灶性白质脑病(PML)患者的特征进行描述，对该不良事件风险进行评估。

研究人员考察了截止2017年8月31日诺华公司相关药物安全性数据，依据先前诊断标准对PML病情进行评估，考察所有接受芬戈莫德治疗患者的进行性多灶性白质脑病发病率。

研究发现，15名接受非芬戈莫德+那他珠单抗联合治疗的患者，在6个月前发生PML，其中女性11人，平均年龄53岁。14名患者接受了2年以上的芬戈莫德治疗，2名患者药物记录复杂。2名患者接受那他珠单抗治疗，其中1名接受那他珠单抗治疗患者在最后1次用药3年零9个月后诊断为PML，另1名患者在接受4年6个月的芬戈莫德治疗后终止，转而接受那他珠单抗治疗并在治疗后3个月发展为PML。14名患者的淋巴细胞绝对计数资料可获得，但未发生持续性4级淋巴细胞减少(≤200细胞/μL)。

研究认为，对于未接受过那他珠单抗治疗的患者，接受芬戈莫德导致的进行性多灶性白质脑病风险极低，每1000患者的发病率为0.069，每100000患者年发病3.12例。

与芬戈莫德相关的拓展阅读：

有关芬戈莫德更多资讯

原始出处：

Joseph R. Berger et al. Progressive multifocal leukoencephalopathy after fingolimod treatment. Neurology. April 18，2018.

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2018-10-18 yourmama

#多灶性#

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2018-12-17 xuyu

#进行性多灶性白质脑病#

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2018-12-14 柳叶一刀

#白质#

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2018-10-10 yinhl1978

#Neurol#

40 0
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2019-01-25 showtest

#脑病#

28 0
[GetPortalCommentsPageByObjectIdResponse(id=1981199, encodeId=67ea19811992d, content=<a href='/topic/show?id=ccaf4332947' target=_blank style='color:#2F92EE;'>#多灶性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43329, encryptionId=ccaf4332947, topicName=多灶性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a885259, createdName=yourmama, createdTime=Thu Oct 18 02:20:00 CST 2018, time=2018-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1700886, encodeId=5c151e0088609, content=<a href='/topic/show?id=5bc99439474' target=_blank style='color:#2F92EE;'>#进行性多灶性白质脑病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94394, encryptionId=5bc99439474, topicName=进行性多灶性白质脑病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c15930270246, createdName=xuyu, createdTime=Mon Dec 17 06:20:00 CST 2018, time=2018-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765715, encodeId=f32b1e65715ae, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Fri Dec 14 15:20:00 CST 2018, time=2018-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000398, encodeId=b341200039878, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Oct 10 09:20:00 CST 2018, time=2018-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1666416, encodeId=9eba1666416ff, content=<a href='/topic/show?id=55c6849451c' target=_blank style='color:#2F92EE;'>#脑病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84945, encryptionId=55c6849451c, topicName=脑病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=db0126060584, createdName=showtest, createdTime=Fri Jan 25 23:20:00 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1976609, encodeId=31c019e660932, content=<a href='/topic/show?id=acd4943925f' target=_blank style='color:#2F92EE;'>#进行性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94392, encryptionId=acd4943925f, topicName=进行性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=869698, createdName=ligang4439, createdTime=Sun Dec 09 20:20:00 CST 2018, time=2018-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620952, encodeId=e3e2162095247, content=<a href='/topic/show?id=92008691089' target=_blank style='color:#2F92EE;'>#芬戈莫德#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86910, encryptionId=92008691089, topicName=芬戈莫德)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=311d20178410, createdName=shenxlcyp, createdTime=Sun Apr 22 04:20:00 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307603, encodeId=237230e6030c, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Fri Apr 20 13:45:36 CST 2018, time=2018-04-20, status=1, ipAttribution=)]
2018-12-09 ligang4439

#进行性#

20 0
[GetPortalCommentsPageByObjectIdResponse(id=1981199, encodeId=67ea19811992d, content=<a href='/topic/show?id=ccaf4332947' target=_blank style='color:#2F92EE;'>#多灶性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43329, encryptionId=ccaf4332947, topicName=多灶性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a885259, createdName=yourmama, createdTime=Thu Oct 18 02:20:00 CST 2018, time=2018-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1700886, encodeId=5c151e0088609, content=<a href='/topic/show?id=5bc99439474' target=_blank style='color:#2F92EE;'>#进行性多灶性白质脑病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94394, encryptionId=5bc99439474, topicName=进行性多灶性白质脑病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c15930270246, createdName=xuyu, createdTime=Mon Dec 17 06:20:00 CST 2018, time=2018-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765715, encodeId=f32b1e65715ae, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Fri Dec 14 15:20:00 CST 2018, time=2018-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000398, encodeId=b341200039878, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Oct 10 09:20:00 CST 2018, time=2018-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1666416, encodeId=9eba1666416ff, content=<a href='/topic/show?id=55c6849451c' target=_blank style='color:#2F92EE;'>#脑病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84945, encryptionId=55c6849451c, topicName=脑病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=db0126060584, createdName=showtest, createdTime=Fri Jan 25 23:20:00 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1976609, encodeId=31c019e660932, content=<a href='/topic/show?id=acd4943925f' target=_blank style='color:#2F92EE;'>#进行性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94392, encryptionId=acd4943925f, topicName=进行性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=869698, createdName=ligang4439, createdTime=Sun Dec 09 20:20:00 CST 2018, time=2018-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620952, encodeId=e3e2162095247, content=<a href='/topic/show?id=92008691089' target=_blank style='color:#2F92EE;'>#芬戈莫德#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86910, encryptionId=92008691089, topicName=芬戈莫德)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=311d20178410, createdName=shenxlcyp, createdTime=Sun Apr 22 04:20:00 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307603, encodeId=237230e6030c, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Fri Apr 20 13:45:36 CST 2018, time=2018-04-20, status=1, ipAttribution=)]
2018-04-22 shenxlcyp

#芬戈莫德#

36 0
[GetPortalCommentsPageByObjectIdResponse(id=1981199, encodeId=67ea19811992d, content=<a href='/topic/show?id=ccaf4332947' target=_blank style='color:#2F92EE;'>#多灶性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43329, encryptionId=ccaf4332947, topicName=多灶性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a885259, createdName=yourmama, createdTime=Thu Oct 18 02:20:00 CST 2018, time=2018-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1700886, encodeId=5c151e0088609, content=<a href='/topic/show?id=5bc99439474' target=_blank style='color:#2F92EE;'>#进行性多灶性白质脑病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94394, encryptionId=5bc99439474, topicName=进行性多灶性白质脑病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c15930270246, createdName=xuyu, createdTime=Mon Dec 17 06:20:00 CST 2018, time=2018-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765715, encodeId=f32b1e65715ae, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Fri Dec 14 15:20:00 CST 2018, time=2018-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000398, encodeId=b341200039878, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Oct 10 09:20:00 CST 2018, time=2018-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1666416, encodeId=9eba1666416ff, content=<a href='/topic/show?id=55c6849451c' target=_blank style='color:#2F92EE;'>#脑病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84945, encryptionId=55c6849451c, topicName=脑病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=db0126060584, createdName=showtest, createdTime=Fri Jan 25 23:20:00 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1976609, encodeId=31c019e660932, content=<a href='/topic/show?id=acd4943925f' target=_blank style='color:#2F92EE;'>#进行性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94392, encryptionId=acd4943925f, topicName=进行性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=869698, createdName=ligang4439, createdTime=Sun Dec 09 20:20:00 CST 2018, time=2018-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620952, encodeId=e3e2162095247, content=<a href='/topic/show?id=92008691089' target=_blank style='color:#2F92EE;'>#芬戈莫德#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86910, encryptionId=92008691089, topicName=芬戈莫德)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=311d20178410, createdName=shenxlcyp, createdTime=Sun Apr 22 04:20:00 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307603, encodeId=237230e6030c, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Fri Apr 20 13:45:36 CST 2018, time=2018-04-20, status=1, ipAttribution=)]
2018-04-20 惠映实验室

学习了.谢谢分享.

67 0

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Neurology：芬戈莫德治疗导致的进行性多灶性白质脑病风险极低

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