MicrobiologyOpen:精油可作为对抗特定多重耐药菌的抗菌剂

2018-07-17 Christine Kelly Wiley

近来,多重耐药菌(MDRO)受到人们越来越多的关注。疾病控制中心将这些多重耐药菌定义为能够“抵抗药物作用的细菌——这些细菌无法被杀死,它们的生长也无法被阻止。”

近来,多重耐药菌(MDRO)受到人们越来越多的关注。疾病控制中心将这些多重耐药菌定义为能够“抵抗药物作用的细菌——这些细菌无法被杀死,它们的生长也无法被阻止。”

细菌的防御能力令人担忧,也是一个亟待解决的问题。医学界正在寻找传统抗生素的可行替代物来对抗这些多重耐药菌。为此,最近的两项研究试图检测几种精油(EO)对人类医学和兽医学中特定病原体的抗菌性能。

Fabiana C. de Aguiar及其同事们研究了8种精油在对抗猪链球菌中的抗菌活性,并将其研究成果发表在了MicrobiologyOpen上。猪链球菌是诸如脑膜炎、关节炎和败血症等多种疾病的主要病原体。此外,这种细菌是一种动物传染病的媒介,这意味它将使与感染猪或感染猪的衍生产品有密切接触的人受到波及。据报道,这种细菌的抗生素耐药性水平很高,需要找到一种替代性的抗菌方法。

S.H. Mohamed及其同事在他们的研究中研究了病原体肺炎克雷伯菌,并将研究成果发表在了Applied Microbiology上。这种细菌能够导致人类受到许多与医疗保健相关的感染,例如肺炎、血流感染和脑膜炎。随着病原通过生物膜的形成对抗生素的耐受性不断增强,这些疾病的治疗向人们提出了越来越多的挑战。

两组研究都将精油作为以上两种病原体治疗困难的潜在解决方案。精油是利用蒸汽蒸馏从植物(例如薄荷、百里香、丁香和桂皮)中提取出来的,以含有多种挥发性物质而闻名。这些挥发性物质使精油具备了抗菌和潜在的抗菌膜特性。

这两项研究的结果证明了精油作为一种对抗特定多重耐药菌的抗菌剂的可行性。一些精油在直接应用于细菌时是有效的,而另一些精油在细菌暴露于精油蒸气时则更有效。两项研究都称,精油可以单独使用,也可以与其他抗菌剂(例如抗生素)一起使用,以提高它们对抗被检测的病原体的能力。然而,这两个研究小组都认为,我们还需要进一步研究精油在体内以及针对不同病原体的安全性和有效性。

原始出处:

Mohamed SH, Mohamed MSM, et al., Combination of essential oil and ciprofloxacin to inhibit/eradicate biofilms in multidrug-resistant Klebsiella pneumoniae. J Appl Microbiol. 2018 Mar 8. doi: 10.1111/jam.13755.

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    2018-11-05 sunylz
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    2018-09-25 xjy02
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    2019-02-24 feather89
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GetPortalCommentsPageByObjectIdResponse(id=1584585, encodeId=637015845850b, content=<a href='/topic/show?id=94d0e645660' target=_blank style='color:#2F92EE;'>#精油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76456, encryptionId=94d0e645660, topicName=精油)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=537517051731, createdName=ms4657536712156177, createdTime=Thu Jul 19 13:51:00 CST 2018, time=2018-07-19, status=1, ipAttribution=)]
  5. 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GetPortalCommentsPageByObjectIdResponse(id=1584585, encodeId=637015845850b, content=<a href='/topic/show?id=94d0e645660' target=_blank style='color:#2F92EE;'>#精油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76456, encryptionId=94d0e645660, topicName=精油)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=537517051731, createdName=ms4657536712156177, createdTime=Thu Jul 19 13:51:00 CST 2018, time=2018-07-19, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1918200, encodeId=899b1918200a7, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Mon Nov 05 15:51:00 CST 2018, time=2018-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084427, encodeId=d287208442ec3, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Jul 22 00:15:12 CST 2018, time=2018-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330758, encodeId=6b0b1330e5892, content=<a href='/topic/show?id=c6b455688d1' target=_blank style='color:#2F92EE;'>#抗菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55688, encryptionId=c6b455688d1, topicName=抗菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Thu Jul 19 13:51:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418679, encodeId=4b7114186e9ff, content=<a href='/topic/show?id=b07e8041efb' target=_blank style='color:#2F92EE;'>#耐药菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80417, encryptionId=b07e8041efb, topicName=耐药菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10723392161, createdName=xiaoshitou, createdTime=Thu Jul 19 13:51:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522637, encodeId=bb3a152263e15, content=<a href='/topic/show?id=e4084348856' target=_blank style='color:#2F92EE;'>#多重耐药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43488, encryptionId=e4084348856, topicName=多重耐药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=476711462137, createdName=gao_jian4221, createdTime=Thu Jul 19 13:51:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584585, encodeId=637015845850b, content=<a href='/topic/show?id=94d0e645660' target=_blank style='color:#2F92EE;'>#精油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76456, encryptionId=94d0e645660, topicName=精油)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=537517051731, createdName=ms4657536712156177, createdTime=Thu Jul 19 13:51:00 CST 2018, time=2018-07-19, status=1, ipAttribution=)]
    2018-07-22 1e0f8808m18(暂无匿称)

    学习了,谢谢分享。

    0

  7. 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  9. 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本研究旨在探究几种选定的市售精油和庆大霉素在对抗产超广谱β-内酰胺酶(ESBL)和产新德里金属-β-内酰胺酶-1(NDM-1)肺炎克雷伯菌分离株之间可能产生的协同效应。 通过双盘协同试验证实了产ESBLs。在所测试的菌株中发现了blaNDM-1基因阳性的菌株。使用肺炎克雷伯菌ATCC BAA-1705 TM菌株作为对照。使用方格棋法评估9种精油的协同作用和添加剂作用:香菜,茴香,薄荷,天竺葵

J Appl Microbiol:精油和环丙沙星联用抑制/消除多重耐药肺炎克雷伯菌生物膜的作用

本研究旨在测试每种精油(EO),EOs的主要化合物和酶,对抗致病性肺炎克雷伯氏菌的生物膜抑制活性。研究人员探究了七种EOs和三种酶对肺炎克雷伯氏菌生物膜的形成和根除的作用。结果显示薄荷油显示强大的生物膜抑制效果,在5μ/ml时抑菌范围为69.2-98.2%。百里香油具有最佳的生物膜清除能力,在10μl/ml时清除率为80.1-98.0%。通过GC/MS分析最有效的EOs,以确定每种油的主要化学成分