Eur Arch Otorhinolaryngol:对葡萄球菌肠毒素的敏感性能预测慢性鼻窦炎的严重程度吗?

2021-02-12 AlexYang MedSci原创

越来越多的证据表明,金黄色葡萄球菌在上、下呼吸道疾病中作为一种疾病调节剂发挥着重要作用。最近,有研究人员评估了金黄色葡萄球菌肠毒素(SEs)与过敏性多发病以及慢性鼻窦炎严重程度的关联。

越来越多的证据表明,金黄色葡萄球菌在上、下呼吸道疾病中作为一种疾病调节剂发挥着重要作用。最近,有研究人员评估了金黄色葡萄球菌肠毒素(SEs)与过敏性多发病以及慢性鼻窦炎严重程度的关联

研究人员回顾性地审查了2018年3月至2019年6月期间97名6岁或以上受试者的医疗记录,并分析了症状评分、计算机断层扫描评分、SEs的血清IgE水平、吸入性过敏原的血清总和特异性IgE水平。结果表明,在入选的97名患者中,29名(29.9%)为非致敏,33名(34.0%)为单致敏,35名(36.1%)为多致敏。对SEs的过敏与对吸入性过敏原的多重过敏密切相关。SE 敏感参与者对吸入性过敏原的总IgE和特异性IgE水平的中位数高于非SE敏感参与者。SE过敏与过敏性多重疾病和严重的过敏性疾病(如ECRS)有关。

最后,研究人员指出,他们的研究初步表明,对SEs的致敏可能在2型炎症反应的起始中发挥作用,如过敏性鼻炎、ECRS和过敏性多种疾病。此外,对SEs的致敏与ECRS的严重程度相关

原始出处:

Eun Jung Lee, Chang-Hoon Kim, Joo-Heon Yoon et al. Can the sensitisation to staphylococcal enterotoxin predict the severity of chronic rhinosinusitis? Eur Arch Otorhinolaryngol. Jan 2021

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