JAHA:婚姻状况会导致亚临床冠状动脉粥样硬化吗?

2022-05-28 MedSci原创 MedSci原创

冠状动脉疾病(CAD)仍然是全球死亡的主要原因。这项大型横断面研究结果表明婚姻状况与亚临床冠状动脉粥样硬化风险增加无关。

冠状动脉疾病(CAD)仍然是全球死亡的主要原因。流行病学研究已经确定了CAD的危险因素,包括年龄、性别、糖尿病高血压、高脂血症、肥胖、吸烟、冠心病家族史和C‐反应蛋白。CAD患者的护理标准就是在这些传统危险因素的基础上制定的。此外,社会经济和社会心理因素等非传统风险因素的作用也日益得到关注。但是,关于婚姻状况与亚临床冠状动脉粥样硬化之间关系的数据较有限。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究旨在探讨婚姻状况对无症状人群经冠状动脉CT血管造影检测的亚临床冠状动脉粥样硬化的影响。

该回顾性研究分析了9288例无冠状动脉疾病史的无症状患者(平均年龄为53.7±8.0岁;6041[65%]名男性),在一般健康检查期间自愿接受冠状动脉CT造影术检查。受试者婚姻类别包括已婚(8481人)和未婚(807人),其中未婚又分为从未结过婚(195人)、离婚(183人)、分居(119人)和丧偶(310人)。冠状动脉CT血管造影评价亚临床冠状动脉粥样硬化的狭窄程度≥50%,被定义为具有临床显著性。研究人员采用Logistic回归和倾向评分匹配分析来确定婚姻状况与亚临床冠状动脉粥样硬化之间的关系。

在调整心血管危险因素后,未结婚受试者CAD斑块(OR为1.077;95%CI为0.899-1.291)、钙化斑块(OR为1.058;95%CI为0.881-1.271)、非钙化斑块(OR为0.966;95%CI为0.691-1.351)、混合斑块(OR为1.301;95%CI为0.884-1.917)以及冠状动脉明显狭窄(OR为1.066;95%CI为0.771-1.474)的调整后比值比未观察到显著差异。同样,在2:1倾向评分匹配的人群中(n=2398),婚姻状况与任何亚临床冠状动脉粥样硬化的OR均未观察到统计学上的显著差异(P>0.05)。

由此可见,这项大型横断面研究结果表明婚姻状况与亚临床冠状动脉粥样硬化风险增加无关。

原始出处:

Soe Hee Ann.et al.Marital Status and Subclinical Coronary Atherosclerosis in Asymptomatic Individuals.JAHA.2022.https://www.ahajournals.org/doi/10.1161/JAHA.121.024942

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    2022-05-29 zhaohui6731
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  4. [GetPortalCommentsPageByObjectIdResponse(id=1944750, encodeId=e5ce1944e5034, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Sat Jul 16 16:24:06 CST 2022, time=2022-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268836, encodeId=6f61126883641, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sun May 29 14:24:06 CST 2022, time=2022-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1222963, encodeId=6475122296333, content=<a href='/topic/show?id=98ba30898c7' target=_blank style='color:#2F92EE;'>#冠状动脉粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30898, encryptionId=98ba30898c7, topicName=冠状动脉粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=清风徐来2022, createdTime=Sat May 28 11:34:59 CST 2022, time=2022-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1247316, encodeId=f405124e3166d, content=大家一般关心疾病,但是亚临床更重要,这是疾病防控方向的前移,各类疾病都是这样。如亚临床甲减,亚临床心肌损伤,亚临床心衰等, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=jingjing, createdTime=Sat May 28 02:24:06 CST 2022, time=2022-05-28, status=1, ipAttribution=)]
    2022-05-28 jingjing

    大家一般关心疾病,但是亚临床更重要,这是疾病防控方向的前移,各类疾病都是这样。如亚临床甲减,亚临床心肌损伤,亚临床心衰等

    0

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