Sci Adv:浙大周民团队用螺旋藻作为药物递送载体,用于结肠癌和结肠炎治疗

2021-11-26 “生物世界”公众号 “生物世界”公众号

口服给药,是胃肠疾病治疗的首选和最常用的给药途径,主要是其具有安全性高、患者依从性高,方便和易于生产等优势。

口服给药,是胃肠疾病治疗的首选和最常用的给药途径,主要是其具有安全性高、患者依从性高,方便和易于生产等优势。然而,口服给药仍存在许多挑战,例如药物活性成分在胃的酸性环境中被降解,导致它们在肠道中的滞留性差和生物利用度低。

为了提高口服给药的疗效,研究人员设计了多种药物载体用于口服给药系统,例如:脂质体、树枝状聚合物、胶束、聚合物偶联物、聚合物纳米颗粒、硅或碳材料以及金属和磁性纳米颗粒等等。

通常,这些候选药物载体是通过复杂设计、合成和构建过程来实现其复杂功能,并通过优化其理化性质,从而使其可用于药物递送和治疗诊断应用。然而这些载体面临的许多重要问题,比如复杂的合成过程带来的技术挑战、高成本和低效率问题。此外,这些人工合成的物质在临床应用时还要面临低生物降解性、不良稳定性、潜在毒性等严重限制。因此,开发一种简便、通用,且生物相容性好的给药策略非常有必要。

2021年11月24日,浙江大学医学院附属第二医院/转化医学研究院周民团队和哈佛医学院陶伟团队合作,在 Science Advances 期刊发表了题为:Orally deliverable strategy based on microalgal biomass for intestinal disease treatment 的研究论文。该论文也是当期封面论文。

该研究将钝顶螺旋藻(Spirulina platensis)这种天然活性微藻作为姜黄素的药物载体,构建了治疗结肠癌和结肠炎这两种肠道疾病的药物递送系统——SP@Curcumin,在肠道疾病治疗中也表现出优异的抗肿瘤和抗炎功效。

在结肠癌的放射治疗中,SP@Curcumin可以联合化疗和放疗抑制肿瘤进展,同时作为放射保护剂清除健康组织中高剂量X射线辐射诱导的活性氧(ROS),从而减少DNA损伤。SP@Curcumin还可以减少促炎细胞因子的产生,从而对结肠炎发挥抗炎作用。

螺旋藻作为一类天然微藻,具有极高的营养价值和良好的生物安全性,可被制作成为人体的营养补充剂。不仅如此,螺旋藻带有负电荷的表面可通过静电吸附装载带正电荷的小分子药物,其细胞膜上的水通道和连接孔也允许小分子通过并进入其膜内,因此对药物具有的较高负载效率。此外,螺旋藻中的天然叶绿素具有荧光特性,无需任何额外的荧光标记即可实现体内的无创追踪。

姜黄素,是姜科植物姜黄(Curcuma longa L.)的活性成分,在我国有几百年的药用历史。近年来的研究表明,姜黄素具有抗氧化作用,能够抗炎和重建骨骼,还有研究表明其能够预防各种癌症。而且,姜黄素也已经被美国FDA批准使用。

在这项研究中,用螺旋藻装载姜黄素(SP@Curcumin),可以在保持结构完整的情况下完整地穿过胃部,然后被肠绒毛捕获并逐渐降解和释放姜黄素,从而在肠道内实现理想的药物分布,且不会引起不良反应。

在传统的结肠癌放疗治疗模型中,SP@Curcumin通过联合化疗和放疗来抑制肿瘤进展,表现出协同治疗效果。同时,SP@Curcumin还通过消除正常细胞中活性氧(ROS) 的产生,减少其诱导的DNA损伤,在放疗过程中保护正常肠道组织。

除了在癌症治疗中的应用,研究团队还展示了SP@Curcumin在肠道中的抗炎能力,它降低了促炎细胞因子的水平并减轻了结肠炎小鼠的炎症相关症状。

总的来说,该研究提出了一种多功能的给药系统SP@Curcumin,可以绕过生理屏障,提高药物特性(如口服生物利用度、生物降解和生物相容性),在肠道疾病治疗中也表现出优异的抗肿瘤和抗炎功效。

浙江大学医学院附属第二医院/转化医学研究院博士生钟丹妮、博士生张东晓、哈佛医学院布莱根妇女医院 Chen Wei 为共同第一作者,浙江大学医学院附属第二医院/转化医学研究院周民、哈佛医学院布莱根妇女医院陶伟为共同通讯作者。

原始出处:

DANNI ZHONG, et al. Orally deliverable strategy based on microalgal biomass for intestinal disease treatment. SCIENCE ADVANCES, 24 Nov 2021, Vol 7, Issue 48. DOI: 10.1126/sciadv.abi9265.

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    2022-05-15 mei539
  4. [GetPortalCommentsPageByObjectIdResponse(id=1967080, encodeId=ee7e196e0807b, content=<a href='/topic/show?id=975988893b6' target=_blank style='color:#2F92EE;'>#螺旋藻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88893, encryptionId=975988893b6, topicName=螺旋藻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Mon Apr 04 05:47:18 CST 2022, time=2022-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1811364, encodeId=33a81811364af, content=<a href='/topic/show?id=6d3f8e886e9' target=_blank style='color:#2F92EE;'>#药物递送载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87886, encryptionId=6d3f8e886e9, topicName=药物递送载体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Wed Apr 13 17:47:18 CST 2022, time=2022-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645504, encodeId=893f164550424, content=<a href='/topic/show?id=db329364360' target=_blank style='color:#2F92EE;'>#载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93643, encryptionId=db329364360, topicName=载体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58cb23213384, createdName=mei539, createdTime=Sun May 15 21:47:18 CST 2022, time=2022-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077081, encodeId=184910e708152, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f9c5702141, createdName=ms6000001711810670, createdTime=Sun Dec 05 15:25:39 CST 2021, time=2021-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1076883, encodeId=006310e688398, content=优秀, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=33385539357, createdName=ms6000000097855691, createdTime=Sat Dec 04 17:04:25 CST 2021, time=2021-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074879, encodeId=174310e4879c9, content=受教, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f32e2382729, createdName=12318330m15暂无昵称, createdTime=Sun Nov 28 21:55:15 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536030, encodeId=815f153603091, content=<a href='/topic/show?id=67446550602' target=_blank style='color:#2F92EE;'>#浙大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65506, encryptionId=67446550602, topicName=浙大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=42f112649926, createdName=pandamao2014, createdTime=Sun Nov 28 10:47:18 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074525, encodeId=181410e452501, content= 诶, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec675553013, createdName=线标, createdTime=Sat Nov 27 15:47:20 CST 2021, time=2021-11-27, status=1, ipAttribution=)]
    2021-12-05 ms6000001711810670

    学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1967080, encodeId=ee7e196e0807b, content=<a href='/topic/show?id=975988893b6' target=_blank style='color:#2F92EE;'>#螺旋藻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88893, encryptionId=975988893b6, topicName=螺旋藻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Mon Apr 04 05:47:18 CST 2022, time=2022-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1811364, encodeId=33a81811364af, content=<a href='/topic/show?id=6d3f8e886e9' target=_blank style='color:#2F92EE;'>#药物递送载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87886, encryptionId=6d3f8e886e9, topicName=药物递送载体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Wed Apr 13 17:47:18 CST 2022, time=2022-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645504, encodeId=893f164550424, content=<a href='/topic/show?id=db329364360' target=_blank style='color:#2F92EE;'>#载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93643, encryptionId=db329364360, topicName=载体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58cb23213384, createdName=mei539, createdTime=Sun May 15 21:47:18 CST 2022, time=2022-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077081, encodeId=184910e708152, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f9c5702141, createdName=ms6000001711810670, createdTime=Sun Dec 05 15:25:39 CST 2021, time=2021-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1076883, encodeId=006310e688398, content=优秀, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=33385539357, createdName=ms6000000097855691, createdTime=Sat Dec 04 17:04:25 CST 2021, time=2021-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074879, encodeId=174310e4879c9, content=受教, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f32e2382729, createdName=12318330m15暂无昵称, createdTime=Sun Nov 28 21:55:15 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536030, encodeId=815f153603091, content=<a href='/topic/show?id=67446550602' target=_blank style='color:#2F92EE;'>#浙大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65506, encryptionId=67446550602, topicName=浙大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=42f112649926, createdName=pandamao2014, createdTime=Sun Nov 28 10:47:18 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074525, encodeId=181410e452501, content= 诶, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec675553013, createdName=线标, createdTime=Sat Nov 27 15:47:20 CST 2021, time=2021-11-27, status=1, ipAttribution=)]
    2021-12-04 ms6000000097855691

    优秀

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1967080, encodeId=ee7e196e0807b, content=<a href='/topic/show?id=975988893b6' target=_blank style='color:#2F92EE;'>#螺旋藻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88893, encryptionId=975988893b6, topicName=螺旋藻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Mon Apr 04 05:47:18 CST 2022, time=2022-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1811364, encodeId=33a81811364af, content=<a href='/topic/show?id=6d3f8e886e9' target=_blank style='color:#2F92EE;'>#药物递送载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87886, encryptionId=6d3f8e886e9, topicName=药物递送载体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Wed Apr 13 17:47:18 CST 2022, time=2022-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645504, encodeId=893f164550424, content=<a href='/topic/show?id=db329364360' target=_blank style='color:#2F92EE;'>#载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93643, encryptionId=db329364360, topicName=载体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58cb23213384, createdName=mei539, createdTime=Sun May 15 21:47:18 CST 2022, time=2022-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077081, encodeId=184910e708152, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f9c5702141, createdName=ms6000001711810670, createdTime=Sun Dec 05 15:25:39 CST 2021, time=2021-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1076883, encodeId=006310e688398, content=优秀, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=33385539357, createdName=ms6000000097855691, createdTime=Sat Dec 04 17:04:25 CST 2021, time=2021-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074879, encodeId=174310e4879c9, content=受教, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f32e2382729, createdName=12318330m15暂无昵称, createdTime=Sun Nov 28 21:55:15 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536030, encodeId=815f153603091, content=<a href='/topic/show?id=67446550602' target=_blank style='color:#2F92EE;'>#浙大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65506, encryptionId=67446550602, topicName=浙大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=42f112649926, createdName=pandamao2014, createdTime=Sun Nov 28 10:47:18 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074525, encodeId=181410e452501, content= 诶, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec675553013, createdName=线标, createdTime=Sat Nov 27 15:47:20 CST 2021, time=2021-11-27, status=1, ipAttribution=)]
    2021-11-28 12318330m15暂无昵称

    受教

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  7. [GetPortalCommentsPageByObjectIdResponse(id=1967080, encodeId=ee7e196e0807b, content=<a href='/topic/show?id=975988893b6' target=_blank style='color:#2F92EE;'>#螺旋藻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88893, encryptionId=975988893b6, topicName=螺旋藻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Mon Apr 04 05:47:18 CST 2022, time=2022-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1811364, encodeId=33a81811364af, content=<a href='/topic/show?id=6d3f8e886e9' target=_blank style='color:#2F92EE;'>#药物递送载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87886, encryptionId=6d3f8e886e9, topicName=药物递送载体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Wed Apr 13 17:47:18 CST 2022, time=2022-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645504, encodeId=893f164550424, content=<a href='/topic/show?id=db329364360' target=_blank style='color:#2F92EE;'>#载体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93643, encryptionId=db329364360, topicName=载体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58cb23213384, createdName=mei539, createdTime=Sun May 15 21:47:18 CST 2022, time=2022-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077081, encodeId=184910e708152, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f9c5702141, createdName=ms6000001711810670, createdTime=Sun Dec 05 15:25:39 CST 2021, time=2021-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1076883, encodeId=006310e688398, content=优秀, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=33385539357, createdName=ms6000000097855691, createdTime=Sat Dec 04 17:04:25 CST 2021, time=2021-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074879, encodeId=174310e4879c9, content=受教, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f32e2382729, createdName=12318330m15暂无昵称, createdTime=Sun Nov 28 21:55:15 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536030, encodeId=815f153603091, content=<a href='/topic/show?id=67446550602' target=_blank style='color:#2F92EE;'>#浙大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65506, encryptionId=67446550602, topicName=浙大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=42f112649926, createdName=pandamao2014, createdTime=Sun Nov 28 10:47:18 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074525, encodeId=181410e452501, content= 诶, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec675553013, createdName=线标, createdTime=Sat Nov 27 15:47:20 CST 2021, time=2021-11-27, status=1, ipAttribution=)]
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    2021-11-27 线标

    0

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