Am J Clin Nutr:膳食宏量营养素对血清尿酸盐的影响:OmniHeart试验的结果

2021-03-13 Dr.Sun Nutrition & Health MedSci原创

长期以来,饮食一直被认为是高尿酸血症和痛风发病机理中一个重要的可改变因素。预防痛风的膳食建议传统上强调减少富含嘌呤的食物(如肉类、海鲜和富含嘌呤的蔬菜)的摄入量,因为嘌呤是嘌呤清除途径中尿酸盐的前体。

长期以来,饮食一直被认为是高尿酸血症和痛风发病机理中一个重要的可改变因素。预防痛风的膳食建议传统上强调减少富含嘌呤的食物(如肉类、海鲜和富含嘌呤的蔬菜)的摄入量,因为嘌呤是嘌呤清除途径中尿酸盐的前体。虽然限制嘌呤的饮食蛋白质含量往往较低,但研究表明,高总蛋白质摄入量与血清尿酸盐升高无关,并且植物性蛋白质的摄入可能与高尿酸症和痛风呈负相关。此外,低嘌呤摄入量教育在减少痛风患者血清尿酸盐方面没有显示出疗效,并且低嘌呤饮食对通常伴随痛风的血管疾病(CVD)危险因素,例如高血压和高脂血症具有的影响还不知道。减少蛋白质摄入量也可能无意中导致精制碳水化合物和饱和脂肪的摄入增加,从而加剧心血管疾病危险因素。

最近的研究表明,停止高血压的饮食方法(DASH)饮食——一种富含碳水化合物的饮食,强调水果、蔬菜和低脂乳制品——除了对血压(BP)和脂质具有确定影响外,还减少了血清尿酸盐。此外,一项大型的前瞻性观察研究发现,DASH饮食可以降低患痛风的风险。

近日,发表在The American Journal of Clinical Nutrition杂志上的一项研究显示,强调植物性蛋白质的DASH式饮食较之强调碳水化合物或不饱和脂肪的DASH式饮食降低了血清尿酸盐。

在这项研究中,来自美国哈佛医学院贝斯以色列女执事医疗中心和约翰斯·霍普金斯大学医学院等研究机构的研究人员进行了预防心脏病最佳宏量营养素摄入试验(OmniHeart)的二次分析,对患有高血压前期或高血压的成年人进行了一个为期3期的交叉设计、随机试验。参与者被随机提供3种DASH式饮食,每种为期6周。每种DASH式饮食强调不同的宏量营养素比例:富含碳水化合物的(CARB)饮食、富含蛋白质的(PROT)饮食和富含不饱和脂肪的 (UNSAT) 饮食。在富含蛋白质的(PROT)饮食中,大约一半的蛋白质来自植物来源。研究人员比较了这些饮食对每一给食期第4周和第6周血清尿酸盐的影响。

试验6周后,研究人员发现,在纳入最终分析的163人中,基线的平均血清尿酸盐为5.1mg/dL。只有富含蛋白质的(PROT)饮食在6周给食期结束时血清尿酸盐从基线下降(–0.16 mg/dL; 95% CI: –0.28, –0.04; P = 0.007)。富含碳水化合物的(CARB)饮食(–0.03 mg/dL; 95% CI: –0.14, 0.09; P = 0.66)和富含不饱和脂肪的(UNSAT)饮食(–0.01 mg/dL; 95% CI: –0.12, 0.09; P = 0.78)两者都没有将血清尿酸盐从基线降低。PROT饮食降低血清尿酸盐比CARB饮食低0.12mg/dL(95% CI: –0.20, –0.03; P = 0.006), 比UNSAT饮食低0.12 mg/dL (95% CI: –0.20, –0.05; P = 0.002)。

不同饮食在基线和至研究周时的平均血清尿酸盐浓度

CARB:富含碳水化合物的饮食

PROT:富含蛋白质的饮食

UNSAT:富含不饱和脂肪的饮食

 

血清尿酸盐的基线变化,mg/dL (n = 163)

研究人员认为,强调植物性蛋白质的DASH式饮食可以通过多种机制降低血清尿酸盐。首先,人类生理研究表明,较高的蛋白质摄入量所观察到的血清尿酸盐下降可能是通过增加尿酸盐排泄和直接的促尿酸排泄效应所介导的。其次,尽管植物性食物中的总嘌呤含量各不相同,但植物蛋白中更易“生成尿酸”的嘌呤(如次黄嘌呤)的比例通常低于动物蛋白。第三,胰岛素抵抗和代偿性高胰岛素血症已被假设为降低尿酸盐的肾清除率。用植物性蛋白质代替富含碳水化合物的饮食的一部分可以减少胰岛素分泌,从而增加血清尿酸盐的肾清除率。最后,PROT饮食包括∼22克/天小麦麸质,这已被证明可以降低血清尿酸盐,独立于肾尿酸盐清除率的变化或胰岛素分泌的变化。

研究人员还指出了该研究的局限性。首先,大多数参与者的基线血清尿酸盐浓度<6毫克/分升,这限制了我们评估DASH式饮食对高尿酸血症(即>7毫克/分升)患者血清尿酸盐的影响能力。其次,中度至重度慢性肾脏疾病、糖尿病、心血管疾病或高脂血症患者被排除在试验之外,这可能限制可推广性。第三,饮食干预持续时间短。因此,我们无法评估持续坚持这种饮食是否会导致血清尿酸盐的更显著下降。第四,干预措施是主要是宏量营养素不同的饮食模式。因此,从设计上来说,PROT饮食的哪个方面是导致血清尿酸盐下降的原因,目前还不确定。第五,尿液尿酸盐不是在24小时的尿液评估中测量的,因此我们无法区分蛋白质饮食降低血清尿酸盐的不同机制。最后,我们的研究是使用原始OmniHart试验中存储的样本进行的几个补充分析之一。然而,本次试验中的血清尿酸盐终点是假说驱动的,依照NIH R01赞助(R01AR065944)(补充方法2)的具体目的。发表意图是在检查血清尿酸盐数据之前做出的,目前的发现反映了测试我们先验假设的努力。不过,我们的结果应被解释为探索性分析和我们在确认试验中检验的结论。

研究人员认为,这项研究有几个健康启示。高尿酸症是痛风发展的确定危险因素,与高血压密切相关,可能是心血管疾病的危险因素。最初的OmniHart试验表明,用蛋白质(大约一半来自植物来源)代替碳水化合物的DASH式饮食进一步降低了血压、低密度脂蛋白胆固醇和甘油三酯。这些发现表明,强调植物性蛋白质的DASH式饮食可能是优化心血管疾病危险因素例如高血压和高脂血症的有效策略,同时降低血清尿酸盐。

总之,与碳水化合物或不饱和脂肪相比,强调更高比例植物性蛋白质的DASH式饮食,降低了患有高血压前期或第1阶段高血压的肥胖或超重成年人的血清尿酸盐。富含蛋白质类型的DASH饮食可能是患有痛风的成年人降低血清尿酸盐的最佳饮食方法,同时还能改善血压和脂质。有必要进行试验来检验强调植物性蛋白质的DASH式饮食降低痛风患者血清尿酸盐和预防痛风发作的能力。

原始出处:

Matthew J Belanger, Christina C Wee et al. Effects of dietary macronutrients on serum urate: results from the OmniHeart trial. Am J Clin Nutr. 2021 Mar 1;nqaa424.  doi: 10.1093/ajcn/nqaa424.  Online ahead of print.

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[GetPortalCommentsPageByObjectIdResponse(id=1237147, encodeId=b2f3123e14793, content=非常好的文章!赞👍但是文中提到的停止高血压翻译似乎不妥,应为?希望校准一下谢谢🙏, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=703a1476598, createdName=dr.huangping, createdTime=Sun Aug 07 20:54:09 CST 2022, time=2022-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992520, encodeId=236a1992520d2, content=<a href='/topic/show?id=93b14e55789' target=_blank style='color:#2F92EE;'>#尿酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47557, encryptionId=93b14e55789, topicName=尿酸盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Thu Jun 10 06:13:06 CST 2021, time=2021-06-10, 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    2022-08-07 dr.huangping

    非常好的文章!赞👍但是文中提到的停止高血压翻译似乎不妥,应为?希望校准一下谢谢🙏

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  3. [GetPortalCommentsPageByObjectIdResponse(id=1237147, encodeId=b2f3123e14793, content=非常好的文章!赞👍但是文中提到的停止高血压翻译似乎不妥,应为?希望校准一下谢谢🙏, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=703a1476598, createdName=dr.huangping, createdTime=Sun Aug 07 20:54:09 CST 2022, time=2022-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992520, encodeId=236a1992520d2, content=<a href='/topic/show?id=93b14e55789' target=_blank style='color:#2F92EE;'>#尿酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47557, encryptionId=93b14e55789, topicName=尿酸盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Thu Jun 10 06:13:06 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350441, encodeId=0a09135044198, content=<a href='/topic/show?id=224a85904ad' target=_blank style='color:#2F92EE;'>#膳食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85904, encryptionId=224a85904ad, topicName=膳食)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357664, encodeId=5354135e66487, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466375, encodeId=79ce14663e5ba, content=<a href='/topic/show?id=6eda8939206' target=_blank style='color:#2F92EE;'>#血清尿酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89392, encryptionId=6eda8939206, topicName=血清尿酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99066802687, createdName=feifers, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536941, encodeId=10f915369414f, content=<a href='/topic/show?id=2dd4128010e' target=_blank style='color:#2F92EE;'>#NIH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12801, encryptionId=2dd4128010e, topicName=NIH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7cd212750364, createdName=宋威, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563422, encodeId=8dbe156342230, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596859, encodeId=0da715968598e, content=<a href='/topic/show?id=a50c88164d1' target=_blank style='color:#2F92EE;'>#营养素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88164, encryptionId=a50c88164d1, topicName=营养素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f04318436029, createdName=lifangping, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=948047, encodeId=b16494804e15, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=46905128057, createdName=zy&kt, createdTime=Sun Mar 14 10:25:12 CST 2021, time=2021-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=947893, encodeId=5d6894e893be, content=很好,已读, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3b25454425, createdName=ms7000000570486449, createdTime=Sat Mar 13 16:22:50 CST 2021, time=2021-03-13, status=1, ipAttribution=)]
    2021-03-15 zhaojie88
  4. [GetPortalCommentsPageByObjectIdResponse(id=1237147, encodeId=b2f3123e14793, content=非常好的文章!赞👍但是文中提到的停止高血压翻译似乎不妥,应为?希望校准一下谢谢🙏, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=703a1476598, createdName=dr.huangping, createdTime=Sun Aug 07 20:54:09 CST 2022, time=2022-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992520, encodeId=236a1992520d2, content=<a href='/topic/show?id=93b14e55789' target=_blank style='color:#2F92EE;'>#尿酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47557, encryptionId=93b14e55789, topicName=尿酸盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Thu Jun 10 06:13:06 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350441, encodeId=0a09135044198, content=<a href='/topic/show?id=224a85904ad' target=_blank style='color:#2F92EE;'>#膳食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85904, encryptionId=224a85904ad, topicName=膳食)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357664, encodeId=5354135e66487, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466375, encodeId=79ce14663e5ba, content=<a href='/topic/show?id=6eda8939206' target=_blank style='color:#2F92EE;'>#血清尿酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89392, encryptionId=6eda8939206, topicName=血清尿酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99066802687, createdName=feifers, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536941, encodeId=10f915369414f, content=<a href='/topic/show?id=2dd4128010e' target=_blank style='color:#2F92EE;'>#NIH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12801, encryptionId=2dd4128010e, topicName=NIH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7cd212750364, createdName=宋威, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563422, encodeId=8dbe156342230, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596859, encodeId=0da715968598e, content=<a href='/topic/show?id=a50c88164d1' target=_blank style='color:#2F92EE;'>#营养素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88164, encryptionId=a50c88164d1, topicName=营养素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f04318436029, createdName=lifangping, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=948047, encodeId=b16494804e15, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=46905128057, createdName=zy&kt, createdTime=Sun Mar 14 10:25:12 CST 2021, time=2021-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=947893, encodeId=5d6894e893be, content=很好,已读, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3b25454425, createdName=ms7000000570486449, createdTime=Sat Mar 13 16:22:50 CST 2021, time=2021-03-13, status=1, ipAttribution=)]
    2021-03-15 zhaojie88
  5. [GetPortalCommentsPageByObjectIdResponse(id=1237147, encodeId=b2f3123e14793, content=非常好的文章!赞👍但是文中提到的停止高血压翻译似乎不妥,应为?希望校准一下谢谢🙏, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=703a1476598, createdName=dr.huangping, createdTime=Sun Aug 07 20:54:09 CST 2022, time=2022-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992520, encodeId=236a1992520d2, content=<a href='/topic/show?id=93b14e55789' target=_blank style='color:#2F92EE;'>#尿酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47557, encryptionId=93b14e55789, topicName=尿酸盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Thu Jun 10 06:13:06 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350441, encodeId=0a09135044198, content=<a href='/topic/show?id=224a85904ad' target=_blank style='color:#2F92EE;'>#膳食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85904, encryptionId=224a85904ad, topicName=膳食)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357664, encodeId=5354135e66487, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466375, encodeId=79ce14663e5ba, content=<a href='/topic/show?id=6eda8939206' target=_blank style='color:#2F92EE;'>#血清尿酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89392, encryptionId=6eda8939206, topicName=血清尿酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99066802687, createdName=feifers, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536941, encodeId=10f915369414f, content=<a href='/topic/show?id=2dd4128010e' target=_blank style='color:#2F92EE;'>#NIH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12801, encryptionId=2dd4128010e, topicName=NIH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7cd212750364, createdName=宋威, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563422, encodeId=8dbe156342230, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596859, encodeId=0da715968598e, content=<a href='/topic/show?id=a50c88164d1' target=_blank style='color:#2F92EE;'>#营养素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88164, encryptionId=a50c88164d1, topicName=营养素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f04318436029, createdName=lifangping, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=948047, encodeId=b16494804e15, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=46905128057, createdName=zy&kt, createdTime=Sun Mar 14 10:25:12 CST 2021, time=2021-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=947893, encodeId=5d6894e893be, content=很好,已读, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3b25454425, createdName=ms7000000570486449, createdTime=Sat Mar 13 16:22:50 CST 2021, time=2021-03-13, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1237147, encodeId=b2f3123e14793, content=非常好的文章!赞👍但是文中提到的停止高血压翻译似乎不妥,应为?希望校准一下谢谢🙏, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=703a1476598, createdName=dr.huangping, createdTime=Sun Aug 07 20:54:09 CST 2022, time=2022-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992520, encodeId=236a1992520d2, content=<a href='/topic/show?id=93b14e55789' target=_blank style='color:#2F92EE;'>#尿酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47557, encryptionId=93b14e55789, topicName=尿酸盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Thu Jun 10 06:13:06 CST 2021, time=2021-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350441, encodeId=0a09135044198, content=<a href='/topic/show?id=224a85904ad' target=_blank style='color:#2F92EE;'>#膳食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85904, encryptionId=224a85904ad, topicName=膳食)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357664, encodeId=5354135e66487, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466375, encodeId=79ce14663e5ba, content=<a href='/topic/show?id=6eda8939206' target=_blank style='color:#2F92EE;'>#血清尿酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89392, encryptionId=6eda8939206, topicName=血清尿酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99066802687, createdName=feifers, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536941, encodeId=10f915369414f, content=<a href='/topic/show?id=2dd4128010e' target=_blank style='color:#2F92EE;'>#NIH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12801, encryptionId=2dd4128010e, topicName=NIH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7cd212750364, createdName=宋威, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563422, encodeId=8dbe156342230, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596859, encodeId=0da715968598e, content=<a href='/topic/show?id=a50c88164d1' target=_blank style='color:#2F92EE;'>#营养素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88164, encryptionId=a50c88164d1, topicName=营养素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f04318436029, createdName=lifangping, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=948047, encodeId=b16494804e15, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=46905128057, createdName=zy&kt, createdTime=Sun Mar 14 10:25:12 CST 2021, time=2021-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=947893, encodeId=5d6894e893be, content=很好,已读, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3b25454425, createdName=ms7000000570486449, createdTime=Sat Mar 13 16:22:50 CST 2021, time=2021-03-13, status=1, ipAttribution=)]
    2021-03-15 宋威
  7. 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topicList=[TopicDto(id=12801, encryptionId=2dd4128010e, topicName=NIH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7cd212750364, createdName=宋威, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563422, encodeId=8dbe156342230, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596859, encodeId=0da715968598e, content=<a href='/topic/show?id=a50c88164d1' target=_blank style='color:#2F92EE;'>#营养素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88164, encryptionId=a50c88164d1, topicName=营养素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f04318436029, createdName=lifangping, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=948047, encodeId=b16494804e15, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=46905128057, createdName=zy&kt, createdTime=Sun Mar 14 10:25:12 CST 2021, time=2021-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=947893, encodeId=5d6894e893be, content=很好,已读, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3b25454425, createdName=ms7000000570486449, createdTime=Sat Mar 13 16:22:50 CST 2021, time=2021-03-13, status=1, ipAttribution=)]
    2021-03-15 slcumt
  8. [GetPortalCommentsPageByObjectIdResponse(id=1237147, encodeId=b2f3123e14793, content=非常好的文章!赞👍但是文中提到的停止高血压翻译似乎不妥,应为?希望校准一下谢谢🙏, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=703a1476598, createdName=dr.huangping, createdTime=Sun Aug 07 20:54:09 CST 2022, time=2022-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992520, encodeId=236a1992520d2, content=<a href='/topic/show?id=93b14e55789' target=_blank style='color:#2F92EE;'>#尿酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47557, encryptionId=93b14e55789, topicName=尿酸盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Thu Jun 10 06:13:06 CST 2021, time=2021-06-10, 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topicList=[TopicDto(id=12801, encryptionId=2dd4128010e, topicName=NIH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7cd212750364, createdName=宋威, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563422, encodeId=8dbe156342230, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596859, encodeId=0da715968598e, content=<a href='/topic/show?id=a50c88164d1' target=_blank style='color:#2F92EE;'>#营养素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88164, encryptionId=a50c88164d1, topicName=营养素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f04318436029, createdName=lifangping, createdTime=Mon Mar 15 06:13:06 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=948047, encodeId=b16494804e15, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=46905128057, createdName=zy&kt, createdTime=Sun Mar 14 10:25:12 CST 2021, time=2021-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=947893, encodeId=5d6894e893be, content=很好,已读, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3b25454425, createdName=ms7000000570486449, createdTime=Sat Mar 13 16:22:50 CST 2021, time=2021-03-13, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1237147, encodeId=b2f3123e14793, content=非常好的文章!赞👍但是文中提到的停止高血压翻译似乎不妥,应为?希望校准一下谢谢🙏, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=703a1476598, createdName=dr.huangping, createdTime=Sun Aug 07 20:54:09 CST 2022, time=2022-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992520, encodeId=236a1992520d2, content=<a href='/topic/show?id=93b14e55789' target=_blank style='color:#2F92EE;'>#尿酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47557, encryptionId=93b14e55789, topicName=尿酸盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Thu Jun 10 06:13:06 CST 2021, time=2021-06-10, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3b25454425, createdName=ms7000000570486449, createdTime=Sat Mar 13 16:22:50 CST 2021, time=2021-03-13, status=1, ipAttribution=)]
    2021-03-14 zy&kt

    学习了

    0

  10. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3b25454425, createdName=ms7000000570486449, createdTime=Sat Mar 13 16:22:50 CST 2021, time=2021-03-13, status=1, ipAttribution=)]
    2021-03-13 ms7000000570486449

    很好,已读

    0

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随着社会经济的发展和居民生活方式的改变,高血压已成为影响全球居民健康的重大公共卫生问题之一。

Hypertension: 遗传因素预测高血压发病与心血管风险

遗传信息可以提高对高血压风险的预测能力

Hypertension:预防高血压,碳水化合物摄入量多少才合适?

碳水化合物摄入量过高或过低都会增加新发高血压的风险,在50%~55%碳水化合物摄入量时风险最小。推荐摄入高质量的碳水化合物(如全谷物,水果,豆类)。

Nat Commun:午睡的遗传因素分析及其对心血管代谢的影响

午睡(Daytime napping)是一种白天的短时睡眠事件。午睡在地中海文化中非常普遍,在包括美国在内的非地中海国家中午睡也一种很常见的事件。在现代社会中,鼓励夜班工人和飞行员等睡眠不足的人群小睡

拓展阅读

Lancet Rheumatology: 痛风患者血清尿酸盐与急性发作之间关联的证据:对两项随机对照试验的二次分析

本研究的目的是评估达到目标血清尿酸与痛风发作之间的因果关系。

ARD:血尿酸盐正常高限也增高血压风险(CARDIA研究)

  美国一项研究显示,即使低于传统高尿酸血症阈值(6.8 mg/dl),血尿酸盐浓度较高亦与未来发生高血压显著相关。论文9月14日在线发表于《风湿病年鉴》(Ann Rheum Dis)。   研究纳入青年冠状动脉危险因素研究(CARDIA)中4752名基线时无高血压者的血清尿酸数据,自1985年起随访20年。结果为,基线时男、女的平均年龄为24.8和24.9岁。与参

Arthritis Res Ther:贫血为痛风新危险因素

    美国一项队列研究显示,贫血是痛风发生的一个新危险因素,其与痛风发生风险增加约1倍相关,且独立于肾功能和血尿酸盐水平。论文8月20日在线发表于《关节炎研究与治疗》(Arthritis Res Ther)杂志。     研究纳入美国4个社区的受试者15791名,随访9年,分析基线贫血状态和痛风发作风险的相关性。贫血的定义为男性血红蛋