JAMA Surg:手术压力与虚弱患者死亡风险

2019-11-19 MedSci MedSci原创

虚弱患者即使接受中低压力手术仍具有较高的术后死亡风险

虚弱患者有较高的术后死亡率和并发症的风险,近日研究人员就不同手术压力水平下的脆弱程度与死亡率之间的关系进行了考察。

研究人员回顾性2010年4月1日到2014年3月31日接受外科质量改进计划的退伍军人数据,患者接受了非心脏外科手术,将手术压力分为5类,以风险分析指标衡量脆弱程度,以手术压力评分衡量手术压力。研究的主要终点为术后30、90和180天的死亡率。

432828名患者,男性占92.8%,平均年龄61.0岁,36579名(8.5%)患者评价为虚弱,9113名(2.1%)为非常虚弱。在身体虚弱、接受压最小压力的手术(如膀胱镜检查)的患者中,30天死亡率为1.55%,在接受中度压力手术(如腹腔镜胆囊切除术)的虚弱患者中,死亡率为5.13%,上述死亡率超过了通常定义的高危手术死亡率(1%)。在非常虚弱的患者中,最低压力手术(10.34%)和中等压力手术(18.74%)后30天死亡率更高。对于虚弱和非常虚弱的患者,死亡率在90天和180天继续增加,在中等压力手术后180天,非常虚弱患者的死亡率达到43.00%。

研究发现,虚弱患者即使接受中低压力手术仍具有较高的术后死亡风险。

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