Clin Nutrition: 少肌症肥胖症与呼吸系统疾病的发生率和死亡率的关系

2020-11-15 MedSci原创 MedSci原创

肌肉减少症肥胖定义为肌肉减少症和肥胖症的组合症状。先前的研究表明,肌肉减少症与呼吸系统疾病之间存在正相关关系,而其他研究则表明,肥胖者患呼吸系统疾病的风险较低。

背景

肌肉减少症肥胖定义为肌肉减少症和肥胖症的组合症状。先前的研究表明,肌肉减少症与呼吸系统疾病之间存在正相关关系,而其他研究则表明,肥胖者患呼吸系统疾病的风险较低。这项研究旨在调查肥胖,少肌症和少肌症肥胖与呼吸系统疾病的发病率和死亡率之间的关系。

 

 

方法

本项研究前瞻性的纳入了英国生物库研究的170083名参与者的数据。肌肉减少症定义为肌肉减少症与以下肥胖症标准之一结合:BMI≥30 kg/m2,女性腰围(WC)≥88 cm或男性≥102 cm。主要观察结果是呼吸系统疾病的发生率和死亡率。

 

 

结果

本项研究的平均随访时间为7.0年。5459(3.2%)名参与者患了呼吸道疾病,而780名(0.5%)因呼吸道疾病而死亡。与没有肥胖或少肌症的人相比,肥胖者(危险比(HR):1.13 [95 CI:1.03; 1.23]),少肌症(HR:1.23 [95%CI:1.10; 1.36])或少肌症者(基于(HR:1.51 [95%CI:1.30; 1.77])发生呼吸道疾病的风险更高。然而,肌肉减少症患者的呼吸系统疾病死亡风险较高,而肥胖者则较低。肌肉减少症肥胖与呼吸系统死亡率之间没有相关性(HR:1.12 [95%CI:0.76; 1.63])。当使用WC或身体脂肪定义肥胖时,发现了相似的结果。

 

 

结论

肥胖,少肌症和少肌症肥胖症与呼吸道疾病发生的风险较高相关。然而,虽然肥胖与低脂血症相关,而少肌症具有较高的呼吸道死亡风险,但未发现少肌症肥胖与呼吸道死亡率之间存在关联。

 

 

 

原始出处:

FannyPetermann-Rocha. Et al. Sarcopenic obesity and its association with respiratory disease incidence and mortality. Clinical Nutrition.2020.

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