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J Thromb Haemost：防止自发性大出血的很低FXIII活性水平！

2017-07-09 xing.T MedSci原创

自发性大出血FXIII活性预防
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PRO-RBDD研究的结果表明FXIII凝血活性的水平为15 IU/分升作为开始预防的目标，以防止大出血，如中枢神经系统和胃肠道出血。

先天性凝血因子XIII（FXIII）缺乏症是一种罕见的出血性疾病，与显著的出血表现相关。罕见的出血性疾病的欧洲网络（EN-RBD）是在2007年至2010年期间进行的，该研究的结果表明在FXIII缺乏患者出血的严重程度与血浆中FXIII活性有很强的相关性。这些患者FXIII活性水平有所不同，从不能检测到至30%不等，与广泛的出血严重程度相关。

近日，血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章，在该横断面研究中，在前瞻性队列研究PRO-RBDD项目的框架内，研究人员分析了64例FXIII缺乏症以及不同类型的临床和实验室严重程度的数据。

该研究结果证实血浆中FXIII凝血活性与患者的临床严重程度相关。此外，研究人员发现FXIII活性低于15IU/分升时，受试者自发性大出血的概率急剧增加（FXIII活性为15 IU/分升时，自发性大出血的概率为50%，而在FXIII活性为5 IU/分升或更低时，自发性大出血的概率为90%）。

PRO-RBDD研究的结果表明FXIII凝血活性的水平为15 IU/分升作为开始预防的目标，以防止大出血，如中枢神经系统和胃肠道出血。

原始出处：

M. Menegatti,et al. Minimal factor XIII activity level to prevent major spontaneous bleeds.Journal of Thrombosis and Haemostasis.2017. http://onlinelibrary.wiley.com/doi/10.1111/jth.13772/full

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    2018-03-18 smartjoy

    #FXII#

    0

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    2017-10-31 ms1292405679162969

    #FXIII#

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    2018-01-25 juliusluan78

    #III#

    0

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target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Tue Jul 11 02:23:00 CST 2017, time=2017-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220606, encodeId=cb2c2206060c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Mon Jul 10 07:35:49 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220584, encodeId=02cf220584b4, content=不错的方式，努力学习，刻苦专研，不断总结出来新经验。给点个赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Jul 10 07:13:51 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220311, encodeId=6b722203118e, content=学习了，受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Jul 09 12:31:12 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2018-02-27 changfy

    #HAE#

    0

  5. 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target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Tue Jul 11 02:23:00 CST 2017, time=2017-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220606, encodeId=cb2c2206060c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Mon Jul 10 07:35:49 CST 2017, time=2017-07-10, status=1, ipAttribution=), 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createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Jul 09 12:31:12 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-11 cmsvly

    #大出血#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2007667, encodeId=8d83200e6676f, content=<a href='/topic/show?id=5ad0e744cd' target=_blank style='color:#2F92EE;'>#FXII#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7744, encryptionId=5ad0e744cd, topicName=FXII)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e76f39, createdName=smartjoy, createdTime=Sun Mar 18 18:23:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956599, encodeId=8d6419565996d, content=<a href='/topic/show?id=8605e745b0' target=_blank style='color:#2F92EE;'>#FXIII#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7745, encryptionId=8605e745b0, topicName=FXIII)], attachment=null, authenticateStatus=null, 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target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Tue Jul 11 02:23:00 CST 2017, time=2017-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220606, encodeId=cb2c2206060c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Mon Jul 10 07:35:49 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220584, encodeId=02cf220584b4, content=不错的方式，努力学习，刻苦专研，不断总结出来新经验。给点个赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Jul 10 07:13:51 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220311, encodeId=6b722203118e, content=学习了，受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Jul 09 12:31:12 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-11 sodoo

    #自发性#

    0

  7. 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target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Tue Jul 11 02:23:00 CST 2017, time=2017-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220606, encodeId=cb2c2206060c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Mon Jul 10 07:35:49 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220584, encodeId=02cf220584b4, content=不错的方式，努力学习，刻苦专研，不断总结出来新经验。给点个赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Jul 10 07:13:51 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220311, encodeId=6b722203118e, content=学习了，受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Jul 09 12:31:12 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-10 Jackie Li

    学习

    0

  8. 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createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Jul 09 12:31:12 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-10 ylzr123

    不错的方式，努力学习，刻苦专研，不断总结出来新经验。给点个赞！

    0

  9. 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    2017-07-09 清风拂面

    学习了，受益匪浅

    0