90后姑娘因熬夜长出老年斑,熬夜给皮肤带来的危害,熬夜党必看!

2021-06-23 K.K MedSci原创

睡眠问题不仅仅是影响颜值,还会引发其他多种问题,如肥胖、脱发、记忆力下降,以及增加心脑血管疾病、甚至老年痴呆的风险。

近几十年来,许多国家的睡眠质量有所下降,特别是在现代工业化社会,睡眠干扰增多,如打鼾、噩梦、磨牙、腿抽筋、梦游症、睡眠瘫痪和白天过度嗜睡。特别是,阻塞性睡眠呼吸暂停(OSA)和失眠分别在男性和女性中高度流行,从而导致睡眠不足。

近日,据广州日报微博报道,18岁高中毕业之后,杭州27岁女子唐羽(化名)就没有在凌晨2点之前睡过觉。上网、追剧……每一个夜深人静的时刻,都是她与自己的狂欢时分。然而最近,她的脸上居然长出了老年斑!通过诊断,唐羽脸上的老年斑属于长期熬夜、精神状态差引发的。改变生活作息后,目前她的老年斑已经出现淡化的迹象。

 

睡眠不足和压力对皮肤的影响

皮肤在调节平衡方面起着基本作用,它位于外部和内部环境之间,它的结构和功能组织容易受到压力的影响。由于睡眠对细胞生长和凋亡至关重要,如果睡眠不足和睡眠质量差可能引起昼夜节律紊乱从而导致细胞功能失调,诱发皮肤变化。曾发表在Journal of the European Academy of Dermatology and Venereology上的研究认为:拥有7~9小时良好睡眠的女性,其皮肤内在老化的迹象较少,太阳模拟辐射后的红斑恢复率较高,与那些睡眠时间少于5小时的不良睡眠者相比,皮肤屏障恢复率高出30%。

T. Passeron et al. Clinical and biological impact of the exposome on the skin.Journal of the European Academy of Dermatology and Venereology.DOI:10.1111/jdv.16614

肾上腺皮质激素是肾上腺皮质部分泌多种激素的总称。肾上腺皮质分泌着与机体生命活动有重要关系的两大类激素,即盐皮质激素和糖皮质激素,同时还分泌少量性激素。

体内糖皮质激素的分泌主要受下丘脑-垂体前叶-肾上腺皮质轴调节。过量的糖皮质激素,对几乎所有的组织都有负面影响,如加速衰老。一些研究还将糖皮质激素的释放与皮肤中胶原蛋白的变化联系起来。

肾上腺糖皮质激素主要是皮质醇,仅有少量皮质酮。皮质醇和促炎症细胞因子,如IL-8和TNF-α,会损害皮肤胶原蛋白和其他皮肤蛋白的产生,增加基质金属蛋白酶的活性,导致水分流失和DNA损伤。

睡眠不足会导致肾上腺皮质系统的过度激活,通过增加皮质酮和促肾上腺皮质激素的产生,对皮肤的完整性产生不利影响。

太阳辐射、空气污染、激素、营养和心理因素(压力和睡眠不足)等个体暴露因素对皮肤的主要影响

 

压力和精神问题会导致睡眠不足

失眠可能与精神类疾病有关,原发性失眠与焦虑、抑郁有关。原发性失眠患者存在入睡困难、睡眠浅、易醒、早醒、多梦、醒后不解乏等症状中的一种或多种。

压力还会导致皮质醇水平增加,而皮质醇会引起晚睡。皮质醇是一种可以由人体自然产生叫做皮质类固醇激素的荷尔蒙,还有人将其称为压力激素,因为人类在面临显着压力时就会产生更多这种荷尔蒙。在皮质醇得到适当控制,不过量分泌时,不会给健康带来负面影响。但压力过大,这种荷尔蒙水平明显过高时就会出现问题,它可以减少提供平静和快乐感觉的血清素数量。

打鼾可能会影响面部外观

女性睡觉打呼噜可能会让容貌变丑,容易出现大眼袋、黑眼圈,皮肤松弛、眼圈色素异变,眼白浑浊不清等,对女性的外表造成很大的影响。2019年,发表Chest的一项干预性交叉研究中,严重阻塞性睡眠呼吸暂停患者(如打鼾)接受持续气道正压(CPAP)治疗或鼻腔扩张器(安慰剂),为期1个月。结果表明,与安慰剂相比,接受1个月的CPAP治疗后,患者的外观更年轻。

一个病人(52岁)在每个实验时间点(基线、安慰剂干预后和CPAP治疗后)的感知年龄

Fabiana Yagihara et al. Patients With OSA Are Perceived as Younger Following Treatment With CPAP.Chest 2019.DOI:https://doi.org/10.1016/j.chest.2019.03.015

当然,睡眠问题不仅仅是影响颜值,还会引发其他多种问题,如肥胖、脱发、记忆力下降,以及增加心脑血管疾病、甚至老年痴呆的风险。在日常生活中,我们要注意调节行为,培养一个稳态的生物钟;中午疲劳的时候小睡一会,这样可以减缓睡眠驱动力,让自己更有干劲;通过冥想、听轻音乐等方式放松情绪,能够抑制我们的唤醒系统,让大脑更容易入睡。

原始出处:

https://onlinelibrary.wiley.com/doi/full/10.1111/jdv.16614

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    2021-11-09 湘雅科教

    已拜读,受益匪浅。

    0

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    2021-10-10 疏疏

    没有夜班就没有伤害

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1068440, encodeId=55271068440f5, content=已拜读,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Tue Nov 09 10:19:48 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1059257, encodeId=9361105925e35, content=没有夜班就没有伤害, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f1cd5514651, createdName=疏疏, createdTime=Sun Oct 10 21:35:47 CST 2021, time=2021-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004079, encodeId=984e10040e934, content=<a href='/topic/show?id=73626e352d1' target=_blank style='color:#2F92EE;'>#熬夜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67352, encryptionId=73626e352d1, topicName=熬夜)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Fri Jul 30 22:17:36 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002488, encodeId=935210024885f, content=少熬夜,违背自然规律, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201016/e69ebf6de4ff4c58975eca21defba7f4/998f896c1f9b4f698397a269727651c6.jpg, createdBy=7b2b5391720, createdName=ms5000000426001883, createdTime=Sun Jul 25 13:07:12 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976493, encodeId=a56c9e649396, content=好好睡觉,好好吃饭, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=042c5514940, createdName=ms8000002067839618, createdTime=Thu Jun 24 11:45:48 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976338, encodeId=fb279e6338a8, content=再次体会熬夜的苦, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdb2944259, createdName=63766754, createdTime=Wed Jun 23 21:46:44 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976276, encodeId=987d9e6276f1, content=一定不能熬夜, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201107/0e992c9cbb7e4bfc82d642ba0e9fe718/6fa4c63468cc49febcc91dba2fb4201a.jpg, createdBy=fa625399541, createdName=DIfh, createdTime=Wed Jun 23 18:22:31 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976249, encodeId=49469e62499f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=de1b5472251, createdName=ms6000001844892893, createdTime=Wed Jun 23 15:52:59 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976211, encodeId=8a0c9e621147, content=不要熬夜, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201016/e69ebf6de4ff4c58975eca21defba7f4/998f896c1f9b4f698397a269727651c6.jpg, createdBy=7b2b5391720, createdName=ms5000000426001883, createdTime=Wed Jun 23 14:13:44 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976208, encodeId=2b749e6208ab, content=熬的不是夜,是生命, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210623/c7562071c5f64cf9bb9d3d89aacad65d/c8237c01c1094e30ad274d346bf8cd52.jpg, createdBy=8a845532090, createdName=ms7000000834976432, createdTime=Wed Jun 23 14:10:21 CST 2021, time=2021-06-23, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1068440, encodeId=55271068440f5, content=已拜读,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Tue Nov 09 10:19:48 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1059257, encodeId=9361105925e35, content=没有夜班就没有伤害, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f1cd5514651, createdName=疏疏, createdTime=Sun Oct 10 21:35:47 CST 2021, time=2021-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004079, encodeId=984e10040e934, content=<a href='/topic/show?id=73626e352d1' target=_blank style='color:#2F92EE;'>#熬夜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67352, encryptionId=73626e352d1, topicName=熬夜)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Fri Jul 30 22:17:36 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002488, encodeId=935210024885f, content=少熬夜,违背自然规律, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201016/e69ebf6de4ff4c58975eca21defba7f4/998f896c1f9b4f698397a269727651c6.jpg, createdBy=7b2b5391720, createdName=ms5000000426001883, createdTime=Sun Jul 25 13:07:12 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976493, encodeId=a56c9e649396, content=好好睡觉,好好吃饭, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=042c5514940, createdName=ms8000002067839618, createdTime=Thu Jun 24 11:45:48 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976338, encodeId=fb279e6338a8, content=再次体会熬夜的苦, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdb2944259, createdName=63766754, createdTime=Wed Jun 23 21:46:44 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976276, encodeId=987d9e6276f1, content=一定不能熬夜, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201107/0e992c9cbb7e4bfc82d642ba0e9fe718/6fa4c63468cc49febcc91dba2fb4201a.jpg, createdBy=fa625399541, createdName=DIfh, createdTime=Wed Jun 23 18:22:31 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976249, encodeId=49469e62499f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=de1b5472251, createdName=ms6000001844892893, createdTime=Wed Jun 23 15:52:59 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976211, encodeId=8a0c9e621147, content=不要熬夜, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201016/e69ebf6de4ff4c58975eca21defba7f4/998f896c1f9b4f698397a269727651c6.jpg, createdBy=7b2b5391720, createdName=ms5000000426001883, createdTime=Wed Jun 23 14:13:44 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976208, encodeId=2b749e6208ab, content=熬的不是夜,是生命, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210623/c7562071c5f64cf9bb9d3d89aacad65d/c8237c01c1094e30ad274d346bf8cd52.jpg, createdBy=8a845532090, createdName=ms7000000834976432, createdTime=Wed Jun 23 14:10:21 CST 2021, time=2021-06-23, status=1, ipAttribution=)]
    2021-07-25 ms5000000426001883

    少熬夜,违背自然规律

    0

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    2021-06-24 ms8000002067839618

    好好睡觉,好好吃饭

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1068440, encodeId=55271068440f5, content=已拜读,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Tue Nov 09 10:19:48 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1059257, encodeId=9361105925e35, content=没有夜班就没有伤害, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f1cd5514651, createdName=疏疏, createdTime=Sun Oct 10 21:35:47 CST 2021, time=2021-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004079, encodeId=984e10040e934, content=<a href='/topic/show?id=73626e352d1' target=_blank style='color:#2F92EE;'>#熬夜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67352, encryptionId=73626e352d1, topicName=熬夜)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Fri Jul 30 22:17:36 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002488, encodeId=935210024885f, content=少熬夜,违背自然规律, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201016/e69ebf6de4ff4c58975eca21defba7f4/998f896c1f9b4f698397a269727651c6.jpg, createdBy=7b2b5391720, createdName=ms5000000426001883, createdTime=Sun Jul 25 13:07:12 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976493, encodeId=a56c9e649396, content=好好睡觉,好好吃饭, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=042c5514940, createdName=ms8000002067839618, createdTime=Thu Jun 24 11:45:48 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976338, encodeId=fb279e6338a8, content=再次体会熬夜的苦, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdb2944259, createdName=63766754, createdTime=Wed Jun 23 21:46:44 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976276, encodeId=987d9e6276f1, content=一定不能熬夜, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201107/0e992c9cbb7e4bfc82d642ba0e9fe718/6fa4c63468cc49febcc91dba2fb4201a.jpg, createdBy=fa625399541, createdName=DIfh, createdTime=Wed Jun 23 18:22:31 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976249, encodeId=49469e62499f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=de1b5472251, createdName=ms6000001844892893, createdTime=Wed Jun 23 15:52:59 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976211, encodeId=8a0c9e621147, content=不要熬夜, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201016/e69ebf6de4ff4c58975eca21defba7f4/998f896c1f9b4f698397a269727651c6.jpg, createdBy=7b2b5391720, createdName=ms5000000426001883, createdTime=Wed Jun 23 14:13:44 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976208, encodeId=2b749e6208ab, content=熬的不是夜,是生命, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210623/c7562071c5f64cf9bb9d3d89aacad65d/c8237c01c1094e30ad274d346bf8cd52.jpg, createdBy=8a845532090, createdName=ms7000000834976432, createdTime=Wed Jun 23 14:10:21 CST 2021, time=2021-06-23, status=1, ipAttribution=)]
    2021-06-23 63766754

    再次体会熬夜的苦

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1068440, encodeId=55271068440f5, content=已拜读,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Tue Nov 09 10:19:48 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1059257, encodeId=9361105925e35, content=没有夜班就没有伤害, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f1cd5514651, createdName=疏疏, createdTime=Sun Oct 10 21:35:47 CST 2021, time=2021-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004079, encodeId=984e10040e934, content=<a href='/topic/show?id=73626e352d1' target=_blank style='color:#2F92EE;'>#熬夜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67352, encryptionId=73626e352d1, topicName=熬夜)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Fri Jul 30 22:17:36 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002488, encodeId=935210024885f, content=少熬夜,违背自然规律, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201016/e69ebf6de4ff4c58975eca21defba7f4/998f896c1f9b4f698397a269727651c6.jpg, createdBy=7b2b5391720, createdName=ms5000000426001883, createdTime=Sun Jul 25 13:07:12 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976493, encodeId=a56c9e649396, content=好好睡觉,好好吃饭, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=042c5514940, createdName=ms8000002067839618, createdTime=Thu Jun 24 11:45:48 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976338, encodeId=fb279e6338a8, content=再次体会熬夜的苦, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdb2944259, createdName=63766754, createdTime=Wed Jun 23 21:46:44 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976276, encodeId=987d9e6276f1, content=一定不能熬夜, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201107/0e992c9cbb7e4bfc82d642ba0e9fe718/6fa4c63468cc49febcc91dba2fb4201a.jpg, createdBy=fa625399541, createdName=DIfh, createdTime=Wed Jun 23 18:22:31 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976249, encodeId=49469e62499f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=de1b5472251, createdName=ms6000001844892893, createdTime=Wed Jun 23 15:52:59 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976211, encodeId=8a0c9e621147, content=不要熬夜, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201016/e69ebf6de4ff4c58975eca21defba7f4/998f896c1f9b4f698397a269727651c6.jpg, createdBy=7b2b5391720, createdName=ms5000000426001883, createdTime=Wed Jun 23 14:13:44 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976208, encodeId=2b749e6208ab, content=熬的不是夜,是生命, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210623/c7562071c5f64cf9bb9d3d89aacad65d/c8237c01c1094e30ad274d346bf8cd52.jpg, createdBy=8a845532090, createdName=ms7000000834976432, createdTime=Wed Jun 23 14:10:21 CST 2021, time=2021-06-23, status=1, ipAttribution=)]
    2021-06-23 DIfh

    一定不能熬夜

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1068440, encodeId=55271068440f5, content=已拜读,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Tue Nov 09 10:19:48 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1059257, encodeId=9361105925e35, content=没有夜班就没有伤害, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f1cd5514651, createdName=疏疏, createdTime=Sun Oct 10 21:35:47 CST 2021, time=2021-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004079, encodeId=984e10040e934, content=<a href='/topic/show?id=73626e352d1' target=_blank style='color:#2F92EE;'>#熬夜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67352, encryptionId=73626e352d1, topicName=熬夜)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Fri Jul 30 22:17:36 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002488, encodeId=935210024885f, content=少熬夜,违背自然规律, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201016/e69ebf6de4ff4c58975eca21defba7f4/998f896c1f9b4f698397a269727651c6.jpg, createdBy=7b2b5391720, createdName=ms5000000426001883, createdTime=Sun Jul 25 13:07:12 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976493, encodeId=a56c9e649396, content=好好睡觉,好好吃饭, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=042c5514940, createdName=ms8000002067839618, createdTime=Thu Jun 24 11:45:48 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976338, encodeId=fb279e6338a8, content=再次体会熬夜的苦, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdb2944259, createdName=63766754, createdTime=Wed Jun 23 21:46:44 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976276, encodeId=987d9e6276f1, content=一定不能熬夜, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201107/0e992c9cbb7e4bfc82d642ba0e9fe718/6fa4c63468cc49febcc91dba2fb4201a.jpg, createdBy=fa625399541, createdName=DIfh, createdTime=Wed Jun 23 18:22:31 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976249, encodeId=49469e62499f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=de1b5472251, createdName=ms6000001844892893, createdTime=Wed Jun 23 15:52:59 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976211, encodeId=8a0c9e621147, content=不要熬夜, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201016/e69ebf6de4ff4c58975eca21defba7f4/998f896c1f9b4f698397a269727651c6.jpg, createdBy=7b2b5391720, createdName=ms5000000426001883, createdTime=Wed Jun 23 14:13:44 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976208, encodeId=2b749e6208ab, content=熬的不是夜,是生命, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210623/c7562071c5f64cf9bb9d3d89aacad65d/c8237c01c1094e30ad274d346bf8cd52.jpg, createdBy=8a845532090, createdName=ms7000000834976432, createdTime=Wed Jun 23 14:10:21 CST 2021, time=2021-06-23, status=1, ipAttribution=)]
    2021-06-23 ms6000001844892893

    学习了

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1068440, encodeId=55271068440f5, content=已拜读,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Tue Nov 09 10:19:48 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1059257, encodeId=9361105925e35, content=没有夜班就没有伤害, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f1cd5514651, createdName=疏疏, createdTime=Sun Oct 10 21:35:47 CST 2021, time=2021-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004079, encodeId=984e10040e934, content=<a href='/topic/show?id=73626e352d1' target=_blank style='color:#2F92EE;'>#熬夜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67352, encryptionId=73626e352d1, topicName=熬夜)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Fri Jul 30 22:17:36 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002488, encodeId=935210024885f, content=少熬夜,违背自然规律, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201016/e69ebf6de4ff4c58975eca21defba7f4/998f896c1f9b4f698397a269727651c6.jpg, createdBy=7b2b5391720, createdName=ms5000000426001883, createdTime=Sun Jul 25 13:07:12 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976493, encodeId=a56c9e649396, content=好好睡觉,好好吃饭, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=042c5514940, createdName=ms8000002067839618, createdTime=Thu Jun 24 11:45:48 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976338, encodeId=fb279e6338a8, content=再次体会熬夜的苦, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdb2944259, createdName=63766754, createdTime=Wed Jun 23 21:46:44 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976276, encodeId=987d9e6276f1, content=一定不能熬夜, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201107/0e992c9cbb7e4bfc82d642ba0e9fe718/6fa4c63468cc49febcc91dba2fb4201a.jpg, createdBy=fa625399541, createdName=DIfh, createdTime=Wed Jun 23 18:22:31 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976249, encodeId=49469e62499f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=de1b5472251, createdName=ms6000001844892893, createdTime=Wed Jun 23 15:52:59 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976211, encodeId=8a0c9e621147, content=不要熬夜, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201016/e69ebf6de4ff4c58975eca21defba7f4/998f896c1f9b4f698397a269727651c6.jpg, createdBy=7b2b5391720, createdName=ms5000000426001883, createdTime=Wed Jun 23 14:13:44 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976208, encodeId=2b749e6208ab, content=熬的不是夜,是生命, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210623/c7562071c5f64cf9bb9d3d89aacad65d/c8237c01c1094e30ad274d346bf8cd52.jpg, createdBy=8a845532090, createdName=ms7000000834976432, createdTime=Wed Jun 23 14:10:21 CST 2021, time=2021-06-23, status=1, ipAttribution=)]
    2021-06-23 ms5000000426001883

    不要熬夜

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1068440, encodeId=55271068440f5, content=已拜读,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Tue Nov 09 10:19:48 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1059257, encodeId=9361105925e35, content=没有夜班就没有伤害, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f1cd5514651, createdName=疏疏, createdTime=Sun Oct 10 21:35:47 CST 2021, time=2021-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004079, encodeId=984e10040e934, content=<a href='/topic/show?id=73626e352d1' target=_blank style='color:#2F92EE;'>#熬夜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67352, encryptionId=73626e352d1, topicName=熬夜)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Fri Jul 30 22:17:36 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002488, encodeId=935210024885f, content=少熬夜,违背自然规律, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201016/e69ebf6de4ff4c58975eca21defba7f4/998f896c1f9b4f698397a269727651c6.jpg, createdBy=7b2b5391720, createdName=ms5000000426001883, createdTime=Sun Jul 25 13:07:12 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976493, encodeId=a56c9e649396, content=好好睡觉,好好吃饭, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=042c5514940, createdName=ms8000002067839618, createdTime=Thu Jun 24 11:45:48 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976338, encodeId=fb279e6338a8, content=再次体会熬夜的苦, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdb2944259, createdName=63766754, createdTime=Wed Jun 23 21:46:44 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976276, encodeId=987d9e6276f1, content=一定不能熬夜, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201107/0e992c9cbb7e4bfc82d642ba0e9fe718/6fa4c63468cc49febcc91dba2fb4201a.jpg, createdBy=fa625399541, createdName=DIfh, createdTime=Wed Jun 23 18:22:31 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976249, encodeId=49469e62499f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=de1b5472251, createdName=ms6000001844892893, createdTime=Wed Jun 23 15:52:59 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976211, encodeId=8a0c9e621147, content=不要熬夜, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201016/e69ebf6de4ff4c58975eca21defba7f4/998f896c1f9b4f698397a269727651c6.jpg, createdBy=7b2b5391720, createdName=ms5000000426001883, createdTime=Wed Jun 23 14:13:44 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976208, encodeId=2b749e6208ab, content=熬的不是夜,是生命, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210623/c7562071c5f64cf9bb9d3d89aacad65d/c8237c01c1094e30ad274d346bf8cd52.jpg, createdBy=8a845532090, createdName=ms7000000834976432, createdTime=Wed Jun 23 14:10:21 CST 2021, time=2021-06-23, status=1, ipAttribution=)]
    2021-06-23 ms7000000834976432

    熬的不是夜,是生命

    0

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