JCEM：循环甘油脂、脂肪肝指数与2型糖尿病发生率

2021-03-25 MedSci原创 MedSci原创

在中国人群中，较高的血浆DAGs和TAGs水平与T2D风险增加相关，这可能部分由肝脏脂肪堆积所解释。

很少有脂质组学研究专门调查循环甘油脂与2型糖尿病(T2D)风险之间的关系，特别是在亚洲人群中。脂肪肝是否或在何种程度上可以解释甘油脂与T2D之间的相关性仍是未知。

近日，内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章，研究人员旨在评估血浆甘油脂与T2D事件之间的关系，并探索肝脏脂肪积累在这种关系中的潜在作用。

这是一项进行了6年随访的前瞻性队列研究，共纳入了1781名年龄在50-70岁的中国人。该研究的主要结局指标为T2D。

在6年随访期间，463名参与者发生了T2D。在错误发现率(FDR)为5%的情况下，在对传统危险因素进行多因素调整后，104种甘油脂中有43个与T2D风险显著相关。经过进一步控制糖化血红蛋白(HbA1c)后，43种甘油脂中仍然有9种处于显著水平，其中包括2种甘油二酯(DAGs)(16:1/20:4和18:2/20:5)和7种甘油三酯(TAGs)(46:1、48:0、48:1、50:0、50:1、50:2和52:2)，甘油脂每增加1个SD对应的相对风险(RRs)(95%置信区间(CIs))从1.16 (1.05 - 1.27)增加到1.23 (1.11-1.36)。然而，对脂肪肝指数(FLI)进行额外调整，大大削弱了这些结果(RRs[95%CIs]为0.88[0.81至0.95]至1.10[1.01至1.21])。介导分析表明FLI可以解释12%-28%的甘油脂与T2D之间的相关性(所有p<0.01)。

由此可见，在中国人群中，较高的血浆DAGs和TAGs水平与T2D风险增加相关，这可能部分由肝脏脂肪堆积所解释。

原始出处：

Zhenhua Niu.et al.Circulating Glycerolipids, Fatty Liver Index and Incidence of Type 2 Diabetes: A Prospective Study among Chinese.JCEM.2021.https://doi.org/10.1210/clinem/dgab165

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2021-12-22 一叶知秋

#发生率#

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2022-03-04 smallant2015

#JCEM#

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2021-04-06 achengzhao

#JCE#

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2021-03-26 ms2000000117745431

学习

65 0
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2021-03-26 misszhang

谢谢MedSci提供最新的资讯

57 0
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2021-03-25 医鸣惊人

认真学习了

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JCEM：循环甘油脂、脂肪肝指数与2型糖尿病发生率

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