Hypertension:幼时缺VitD,长大高血压!

2019-07-22 MedSci MedSci原创

维生素D缺乏与成人高血压有关。目前还不清楚维生素D在生命早期的状态会在多大程度上影响十年后的血压(BP)。近日,《高血压》杂志上发表了一篇文章,评估生命早期的维生素D水平对儿童时期的收缩压(SBP)的影响。本研究是一项前瞻性出生队列研究,2005年-2012年共招募了775名儿童,随访至受试者满18岁。持续低维生素D状态定义为出生时血浆25(OH)D <11ng/mL,儿童早期<25

维生素D缺乏与成人高血压有关。目前还不清楚维生素D在生命早期的状态会在多大程度上影响十年后的血压(BP)。近日,《高血压》杂志上发表了一篇文章,评估生命早期的维生素D水平对儿童时期的收缩压(SBP)的影响。

本研究是一项前瞻性出生队列研究,2005年-2012年共招募了775名儿童,随访至受试者满18岁。持续低维生素D状态定义为出生时血浆25(OH)D <11ng/mL,儿童早期<25 ng/mL。SBP升高定义为SBP≥75百分位。

结果显示:与维生素D水平正常相比,出生时维生素D水平低与3-18岁时SBP升高风险增加相关,优势比(OR)1.38(95% CI 1.01-1.87)。儿童早期维生素D水平低使6-18岁时SBP升高的风险增加1.59倍(95% CI 1.02-2.46)。从出生到儿童早期持续的低维生素D状态与3-18岁时较高的SBP升高风险相关(OR 2.04[95% CI 1.13-3.67])。

总而言之,上述结果表明,生命早期低维生素D水平与儿童和青少年时期血压升高的风险增加有关。本研究有助于指导未来的临床和公共卫生策略,在妊娠和儿童期进行维生素D筛查和补充,以预防或降低血压升高的风险。

原始出处:

Guoying Wang,et al.Vitamin D Trajectories From Birth to Early Childhood and Elevated Systolic Blood Pressure During Childhood and Adolescence. https://doi.org/10.1161/HYPERTENSIONAHA.119.13120Hypertension. 2019;74:421–430

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    2020-04-29 feather89
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    2019-07-23 130****4638

    婴幼儿时期补充维生素AD的重要性。

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    2019-07-22 orangesking

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