JAHA:体力活动与高血压患者死亡率和心血管疾病发病率的前瞻性关联

2022-03-06 MedSci原创 MedSci原创

该研究结果强调了体育锻炼对高血压患者的重要性,并提供了新的证据来支持为这一高危人群制定体育锻炼指南建议。

高血压是全球心血管疾病(CVD)和过早死亡的主要可改变原因。在全球范围内,高血压影响超过10亿人,每年造成1040万人死亡。高血压的患病率和对CVD发病率和死亡率的不利影响正在不断增加。因此,找到具有成本效益的策略来减轻高血压负担至关重要。体力活动与高血压患者心血管疾病(CVD)发病率和死亡率之间的关系尚不清楚。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员评估了经设备测量的身体活动与高血压成人全因死亡率和CVD死亡率以及CVD发病率(总、卒中和冠心病)的剂量反应关联。

这项前瞻性研究纳入了来自英国生物库研究中39294名高血压参与者的数据,这些参与者拥有有效的加速度测量数据,并且可以获得死亡率和CVD随访数据。研究人员根据第10、第50和第90个百分位数将中度至剧烈的身体活动和总身体活动量分为4类,并使用Cox回归来估计它们与CVD死亡率和发病率结果之间的关联。样条用于评估剂量反应关联。

在6.25年(241418人次每年)的中位随访期间,共登记了1518例死亡(549例归因于CVD)和4933例CVD(致命和非致命)事件。与最低类别的中等至剧烈运动相比,体力活动增加类别的全因死亡率的相对风险(风险比和95%CI)分别为0.53(0.46-0.61)、0.41(0.34-0.49)和0.36(0.26–0.49)。研究人员发现CVD总发病率、卒中和冠心病的关联程度相似。对于所有结局,体力活动与其存在线性或接近线性的反向剂量反应关系,没有证据表明高水平的身体活动有害。剔除在前2年内死亡的参与者的结果仍是稳健的。

由此可见,该研究结果强调了体育锻炼对高血压患者的重要性,并提供了新的证据来支持为这一高危人群制定体育锻炼指南建议。

 

原始出处:

Borja del Pozo Cruz.et al.Prospective Associations of Accelerometer‐Assessed Physical Activity With Mortality and Incidence of Cardiovascular Disease Among Adults With Hypertension: The UK Biobank Study.JAHA.2022.https://www.ahajournals.org/doi/full/10.1161/JAHA.121.023290

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createdName=1508842480_96220437, createdTime=Thu Jun 30 23:53:28 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823803, encodeId=a225182380303, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Mon Jan 23 11:53:28 CST 2023, time=2023-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798865, encodeId=17ce1e98865a8, content=<a href='/topic/show?id=a265e065469' target=_blank style='color:#2F92EE;'>#疾病发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70654, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa362453174, createdName=123fc16fm50暂无昵称, createdTime=Mon Mar 07 10:34:45 CST 2022, time=2022-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1200042, encodeId=893b1200042dc, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210302/d7aef29f1c284560b978861e2a96fbb2/c495254e3ce54350a8a4f1eb91e884c8.jpg, createdBy=15e55464744, createdName=坚定的心, createdTime=Sun Mar 06 21:55:15 CST 2022, time=2022-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1199989, encodeId=24fc1199989e9, content=<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00b23462159, createdName=130a765fm69暂无昵称, createdTime=Sun Mar 06 19:47:59 CST 2022, time=2022-03-06, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1983765, encodeId=82bb1983e659d, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sun Aug 14 01:53:28 CST 2022, time=2022-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006555, encodeId=d9d0200655587, content=<a href='/topic/show?id=924a3264381' target=_blank style='color:#2F92EE;'>#前瞻性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32643, encryptionId=924a3264381, topicName=前瞻性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5cb32500112, 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level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Tue Mar 08 02:53:28 CST 2022, time=2022-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1499037, encodeId=1153149903e6b, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Tue Mar 08 02:53:28 CST 2022, time=2022-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1200181, encodeId=47fc1200181f3, content=临床实用性大, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa362453174, createdName=123fc16fm50暂无昵称, createdTime=Mon Mar 07 10:34:45 CST 2022, time=2022-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1200042, encodeId=893b1200042dc, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210302/d7aef29f1c284560b978861e2a96fbb2/c495254e3ce54350a8a4f1eb91e884c8.jpg, createdBy=15e55464744, createdName=坚定的心, createdTime=Sun Mar 06 21:55:15 CST 2022, time=2022-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1199989, encodeId=24fc1199989e9, content=<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00b23462159, createdName=130a765fm69暂无昵称, createdTime=Sun Mar 06 19:47:59 CST 2022, time=2022-03-06, status=1, ipAttribution=)]
    2022-03-08 zhaohui6731
  6. [GetPortalCommentsPageByObjectIdResponse(id=1983765, encodeId=82bb1983e659d, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sun Aug 14 01:53:28 CST 2022, time=2022-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006555, encodeId=d9d0200655587, content=<a href='/topic/show?id=924a3264381' target=_blank style='color:#2F92EE;'>#前瞻性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32643, encryptionId=924a3264381, topicName=前瞻性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5cb32500112, 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  7. 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  8. 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style='color:#2F92EE;'>#高血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00b23462159, createdName=130a765fm69暂无昵称, createdTime=Sun Mar 06 19:47:59 CST 2022, time=2022-03-06, status=1, ipAttribution=)]
    2022-03-07 123fc16fm50暂无昵称

    临床实用性大

    0

  9. 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    2022-03-06 坚定的心

    学习了

    0

  10. 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