Cell Metab:间歇性禁食改善多发性硬化症

2018-07-11 海北 MedSci原创

最近,来自华盛顿大学医学院的研究人员发现,间歇性禁食(IF)改善了MS模型和实验性自身免疫性脑脊髓炎(EAE)的临床过程和病理学。

多发性硬化症(MS)在西方国家更为常见,饮食是潜在的促成因素。
最近,来自华盛顿大学医学院的研究人员发现,间歇性禁食(IF)改善了MS模型和实验性自身免疫性脑脊髓炎(EAE)的临床过程和病理学。
IF导致肠道细菌丰富度增加,Lactobacillaceae,Bacteroidaceae和Prevotellaceae家族的富集,以及抗氧化微生物代谢途径的增强。IF还能够改变肠道中的T细胞,减少产生IL-17的T细胞和增加调节性T细胞。来自IF小鼠的粪便微生物组移植在正常饮食的免疫受体小鼠中改善了EAE,表明IF效应至少部分由肠道菌群介导。
此外,在MS患者的临床试验中,间歇性能量限制改变了血液脂肪因子和肠道菌群,类似于在小鼠中观察到的保护性变化。
总之,IF具有有效的免疫调节作用,其至少部分由肠道微生物组介导。

原始出处:
Cignarella F et al. Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota. Cell Metabolism 2018, DOI: 10.1016/j.cmet.2018.05.006

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    2018-10-06 guojianrong
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    2018-08-29 jml2009
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1887908, encodeId=a7e8188e908e9, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Sat Oct 06 05:40:00 CST 2018, time=2018-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870739, encodeId=067418e0739c9, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, 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  6. 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channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Wed Jul 11 13:34:21 CST 2018, time=2018-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=330790, encodeId=393c330e905d, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Wed Jul 11 07:36:26 CST 2018, time=2018-07-11, status=1, ipAttribution=), 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    2019-01-20 维他命
  7. 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GetPortalCommentsPageByObjectIdResponse(id=330785, encodeId=bd19330e8565, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/iaAVWEsIJUkA1ITy3uL0lhHUhyaJibWgFtH4KbJuaLbY2WUK33jgCFyoZ8Eqx7eE7hCuZhytc1C5GRrfjVXN8lYg/0, createdBy=fcb82149579, createdName=183****7028, createdTime=Wed Jul 11 07:34:29 CST 2018, time=2018-07-11, status=1, ipAttribution=)]
    2018-09-10 一闲
  8. 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    2018-07-11 qingfengqishi5

    学习了.学习了

    0

  9. 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    2018-07-11 神功盖世

    0

  10. 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    2018-07-11 183****7028

    学习

    0

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【禁食对糖尿病患者的风险:胰岛素泵VS人工注射】在此前的研究中,科学家曾称“模拟禁食”法可以逆转糖尿病的治疗。我们都知道,在沙特等国,存在着斋戒月,在此期间人们会完全禁食,包括糖尿病患者。近期,来自沙特阿拉伯的一支研究团队科学人员对1型糖尿病患者在斋戒禁食期间的风险以及各种日常护理措施进行了对比,其中包括使用胰岛素泵和每日多次注射胰岛素这两种不同的情况下,血糖的控制,低血糖症的比例以及高血糖症的区