乙酸抗细菌生物膜作用的研究进展

2016-10-05 佚名 中华烧伤杂志

作者:高欣欣 金正花 陈欣欣 于家傲 吉林大学第一医院烧伤外科 细菌生物膜因其独特的组织结构,而对抗生素及其他抗菌物质有极强的耐药性。美国疾病控制中心相关数据表明,65%~80%的人类细菌感染与细菌生物膜有关,50%的院内感染与医疗器械装置上的细菌生物膜有关。细菌生物膜已经成为慢性感染迁延不愈,手术及局部给药治疗效果不佳的主要原因之一。乙酸作为

作者:高欣欣 金正花 陈欣欣 于家傲 吉林大学第一医院烧伤外科

 

细菌生物膜因其独特的组织结构,而对抗生素及其他抗菌物质有极强的耐药性。美国疾病控制中心相关数据表明,65%~80%的人类细菌感染与细菌生物膜有关,50%的院内感染与医疗器械装置上的细菌生物膜有关。细菌生物膜已经成为慢性感染迁延不愈,手术及局部给药治疗效果不佳的主要原因之一。乙酸作为抗菌剂及防治瘟疫的药物已有6 000多年的历史。最新实验表明,乙酸具有确切的抑制及清除细菌生物膜的作用,但因其作用机制及毒性和不良反应尚未明确,无法在临床得到广泛应用。本文旨在通过概述细菌生物膜的特点、主要治疗方法及乙酸抗细菌生物膜作用的研究进展,进一步明确乙酸在慢性感染治疗中的重要意义。

 

1 细菌生物膜的特点及治疗方法

 

自然界中的细菌主要有2种生长形式,即单细胞生长和黏附聚集生长。浮游细菌主要采用前一种形式,多种细菌或菌落及其外层形成的细菌生物膜主要采用后一种形式。细菌生物膜形成的过程可以概括为4个阶段:细菌的黏附,菌落的形成及扩增,细菌生物膜的成熟,细菌生物膜的裂解及裂解后细菌的播散。细菌生物膜通过分泌胞外聚合物(EPS)形成包裹多种细菌的保护层,帮助细菌生物膜抵御外界环境及抗生素和其他抗微生物制剂的渗入。EPS主要由细胞外大分子组成,包括核酸、蛋白质、多糖以及脂质。细菌生物膜特有的结构特征还使其具有极强的逃避宿主免疫攻击的能力。20世纪80年代,一系列的体内及体外实验表明,细菌的聚集生长是引起临床慢性感染的重要原因。随后10余年,医学领域开展了多项细菌生物膜相关的体内及体外实验,更深入详实地验证了细菌生物膜导致临床多种慢性感染的理论,包括移植物及导管的感染、人工心脏瓣膜感染、牙菌斑的形成、肺囊性纤维化、中耳炎、慢性创面以及慢性骨髓炎。

 

细菌生物膜理论的提出使慢性感染的治疗迈出了重要一步,临床上主要的治疗方法有合理应用抗生素,局部抗菌物质的使用及去除感染灶。近10年,越来越多的研究者认为全身使用抗生素可以在很大程度上控制伤口感染。但成熟的细菌生物膜对普通治疗剂量甚至高剂量的抗生素极度不敏感,故单纯使用抗生素依然无法达到有效控制及抑制细菌生物膜的目的。选择合适的局部抗菌敷料及抗菌剂,对于防止及控制细菌生物膜形成和增长具有重要意义。银离子敷料是目前临床应用较为广泛的一种抗菌保湿敷料,Stobie等的研究阐明了银离子敷料可以有效抑制表皮葡萄球菌黏附在物体表面,进而抑制细菌生物膜的形成。但含银敷料长期使用的毒性和不良反应尚需实验加以证实。局部皮肤抗菌剂包括硝酸银、醋酸磺胺米隆、碘伏、磺胺嘧啶银及氯己定等,但研究表明,上述这些传统的抗菌剂常规剂量并无明显的抑制及清除细菌生物膜的效果。且Wilson等提出,皮肤局部抗菌剂长期使用可能会损伤Fb和KC,导致创面愈合延迟。针对有细菌生物膜相关感染的慢性创面,彻底清创是去除细菌生物膜的黄金标准,通过这种方法能够去除失活的组织并破坏细菌生物膜,但这种有创的方式不仅给患者带来极大痛苦,且易残留部分游离细菌,容易再次形成细菌生物膜。上述治疗方法均无法有效抑制细菌生物膜的形成及增长,故细菌生物膜的治疗成为医学领域亟须解决的难题。

 

2 乙酸的制备及使用历史

 

酸性环境的建立是控制细菌生长的重要方法之一。20世纪60年代,有机酸在食品安全领域即得到广泛使用,主要用于抗食物变质腐烂。近年来,有机酸及酸性催化剂仍然在抗菌及酸性环境的构建方面起着重要作用。与无机酸相比,有机酸具有更广谱的抑制病原体生长代谢及破坏微生物的作用。有机酸可以未解离的酸性化合物的形式自由通过膜性结构,到达膜内后,酸性化合物发生解离,释放出氢离子,导致细胞内pH值下降,细菌细胞内环境发生改变,从而达到抗菌的效果。

 

目前研究证实的具有抗菌及抗细菌生物膜作用的有机酸主要有透明质酸及乙酸。体外实验证明,透明质酸可以有效抑制呼吸道相关菌群的生长及细菌生物膜的发展和成熟。乙酸是一种无色、有刺激性气味的有机酸。乙酸的制备主要有2种方法,即人工合成法和生物发酵法。前者主要以甲醇或乙醛为原料,利用工业催化剂进行化学反应制备乙酸;后者主要以乙醇、粮食或者糖类为原料,在醋酸菌属及梭菌属的作用下发酵得到乙酸。乙酸不仅是食品领域常用的防腐剂及果蔬消毒剂,也可作为医用的创面及防治瘟疫的抗菌剂。1916年,Taylor首次使用体积分数1%的乙酸,历时2周治愈了铜绿假单胞菌感染的战伤创面。随后几年,乙酸成功治愈了耳部、胸部及尿路的假单胞菌感染。20世纪中期,医学界开始研究乙酸的抗菌作用,且经体外实验证明乙酸具有抗菌效果,对革兰阴性菌的抑制效果优于革兰阳性菌。

 

3 乙酸抗细菌生物膜作用

 

研究表明,酸性环境的建立对于细菌生物膜的形成具有重要影响。Nostro等的研究显示,pH值为5.0和6.0时,乙酸、乳酸及盐酸对金黄色葡萄球菌及表皮葡萄球菌均有抑制作用及抗其细菌生物膜的作用。pH值为5.0时抗菌及抗细菌生物膜能力由强到弱依次为乙酸、乳酸、盐酸;上调pH值到6.0时,3种酸抗细菌生物膜能力强弱没有改变,但对细菌生物膜的抑制作用均有所下降。因实验设定的2种pH值均大于乙酸及乳酸的解离常数pKa(分别为4.75、3.86),而更接近于乙酸的pKa,在此条件下,未解离状态的乙酸要多于乳酸,因此乙酸抗细菌生物膜的能力强于乳酸。故研究者认为,酸性物质对于细菌生物膜的抑制效果主要取决于酸的类型及pH值。

 

Bjarnsholt等的研究显示,体积分数0.5%的乙酸在连续作用24 h后,可将铜绿假单胞菌野生型菌株形成的成熟细菌生物膜完全清除;完全清除金黄色葡萄球菌野生型菌株形成的成熟细菌生物膜则需要体积分数1%的乙酸,而相同体积分数的盐酸对上述2种细菌的成熟细菌生物膜均没有清除效果。乙酸的pH值小于其pKa时,对于铜绿假单胞菌形成的细菌生物膜具有明显的清除效果,而同样pH值的盐酸对铜绿假单胞菌形成的细菌生物膜清除效果不明显。不同pH值(均小于5.0)的乙酸与妥布霉素、环丙沙星、多黏菌素联合作用于细菌生物膜的清除效果明显优于乙酸单独使用。该研究明确了乙酸体外抗细菌生物膜的作用效果,并描述了乙酸在临床应用中与负压吸引疗法联合作用于慢性感染创面的确切治疗效果。

 

Halstead等指出,乙酸对创面感染相关的29种细菌的最小抑菌体积分数为0.16%~0.31%,抑制细菌生物膜形成的最低体积分数为0.31%,清除细菌生物膜的体积分数区间是0.31%~5.00%,而相同pH值的盐酸并没有抗铜绿假单胞菌或鲍氏不动杆菌生物膜的作用。

 

综上,乙酸具有体外抗细菌生物膜形成及清除细菌生物膜的作用,且其抗细菌生物膜的作用与溶液中的氢离子浓度没有直接关系。乙酸等弱有机酸抗菌及抗细菌生物膜能力的主要机制在于未解离状态的酸可以自由扩散通过膜的疏水层,破坏膜内微环境的阳离子及阴离子平衡,导致进入细胞内的乙酸开始解离、游离的氢离子逐步累积,细胞内蛋白降解、膜性结构及DNA结构损坏。

 

4 总结与展望

 

细菌生物膜是目前临床治疗慢性感染需要攻克的难题,明确乙酸抑制及清除细菌生物膜的作用无疑将给临床细菌生物膜及慢性感染的治疗带来希望。故笔者认为有必要开展进一步的实验研究,明确不同状态、不同体积分数的乙酸在不同pH值环境下,抗菌及抗细菌生物膜作用的具体机制及影响因素,从分子及基因水平明确乙酸及酸性环境对基因调控及分子表达的影响。

 

乙酸的产生途径之一是由糖在酵母菌、醋酸菌或梭菌的作用下经过两步法或一步法发酵而得的,目前临床上高渗糖治疗慢性创面的疗效显著,那么是否可以假设糖在作用于创面后,是通过产生乙酸起到了抗感染及促进创面愈合的作用的呢?如果假设成立,我们可以通过活体实验探索促进高渗糖转变为乙酸的条件,从而规避乙酸使用过程中产生的刺痛感及异味等不足,及可能发生的酸中毒风险。

 

尽管乙酸作为抗菌剂使用历史悠久,由于新兴生物技术的迅猛发展,这种传统的抗菌剂逐渐被人遗忘,但对于乙酸的临床及基础研究近2年逐渐兴起,研究者们开始聚焦乙酸对于细菌生物膜的抑制作用。也正因为如此,本文可引用的参考文献时间跨度较大,且近5年文献较少。

 

来源:中华烧伤杂志2016年第32卷第6期

 

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  1. [GetPortalCommentsPageByObjectIdResponse(id=146384, encodeId=08f114638433, content=棒棒哒~, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:41:18 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146382, encodeId=2a7c146382a4, content=以后有发展, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:41:06 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146379, encodeId=285d1463e9d1, content=这个实验不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:56 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146376, encodeId=9b671463e6ed, content=观点很有创新, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:43 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146373, encodeId=34ac1463e3c5, content=也很有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:31 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146370, encodeId=38091463e07c, content=文章很全面, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:12 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146367, encodeId=85f814636e25, content=值得学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:59 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146365, encodeId=505614636538, content=确实很有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:53 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146363, encodeId=d14014636316, content=乙酸还有这个效果, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:42 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146348, encodeId=f6f3146348fb, content=这个研究不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:38:18 CST 2016, time=2016-10-12, status=1, ipAttribution=)]
    2016-10-12 drmike

    棒棒哒~

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=146384, encodeId=08f114638433, content=棒棒哒~, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:41:18 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146382, encodeId=2a7c146382a4, content=以后有发展, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:41:06 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146379, encodeId=285d1463e9d1, content=这个实验不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:56 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146376, encodeId=9b671463e6ed, content=观点很有创新, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:43 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146373, encodeId=34ac1463e3c5, content=也很有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:31 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146370, encodeId=38091463e07c, content=文章很全面, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:12 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146367, encodeId=85f814636e25, content=值得学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:59 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146365, encodeId=505614636538, content=确实很有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:53 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146363, encodeId=d14014636316, content=乙酸还有这个效果, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:42 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146348, encodeId=f6f3146348fb, content=这个研究不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:38:18 CST 2016, time=2016-10-12, status=1, ipAttribution=)]
    2016-10-12 drmike

    以后有发展

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=146384, encodeId=08f114638433, content=棒棒哒~, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:41:18 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146382, encodeId=2a7c146382a4, content=以后有发展, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:41:06 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146379, encodeId=285d1463e9d1, content=这个实验不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:56 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146376, encodeId=9b671463e6ed, content=观点很有创新, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:43 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146373, encodeId=34ac1463e3c5, content=也很有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:31 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146370, encodeId=38091463e07c, content=文章很全面, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:12 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146367, encodeId=85f814636e25, content=值得学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:59 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146365, encodeId=505614636538, content=确实很有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:53 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146363, encodeId=d14014636316, content=乙酸还有这个效果, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:42 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146348, encodeId=f6f3146348fb, content=这个研究不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:38:18 CST 2016, time=2016-10-12, status=1, ipAttribution=)]
    2016-10-12 drmike

    这个实验不错

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=146384, encodeId=08f114638433, content=棒棒哒~, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:41:18 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146382, encodeId=2a7c146382a4, content=以后有发展, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:41:06 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146379, encodeId=285d1463e9d1, content=这个实验不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:56 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146376, encodeId=9b671463e6ed, content=观点很有创新, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:43 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146373, encodeId=34ac1463e3c5, content=也很有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:31 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146370, encodeId=38091463e07c, content=文章很全面, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:12 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146367, encodeId=85f814636e25, content=值得学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:59 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146365, encodeId=505614636538, content=确实很有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:53 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146363, encodeId=d14014636316, content=乙酸还有这个效果, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:42 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146348, encodeId=f6f3146348fb, content=这个研究不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:38:18 CST 2016, time=2016-10-12, status=1, ipAttribution=)]
    2016-10-12 drmike

    观点很有创新

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=146384, encodeId=08f114638433, content=棒棒哒~, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:41:18 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146382, encodeId=2a7c146382a4, content=以后有发展, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:41:06 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146379, encodeId=285d1463e9d1, content=这个实验不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:56 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146376, encodeId=9b671463e6ed, content=观点很有创新, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:43 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146373, encodeId=34ac1463e3c5, content=也很有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:31 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146370, encodeId=38091463e07c, content=文章很全面, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:12 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146367, encodeId=85f814636e25, content=值得学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:59 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146365, encodeId=505614636538, content=确实很有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:53 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146363, encodeId=d14014636316, content=乙酸还有这个效果, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:42 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146348, encodeId=f6f3146348fb, content=这个研究不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:38:18 CST 2016, time=2016-10-12, status=1, ipAttribution=)]
    2016-10-12 drmike

    也很有趣

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=146384, encodeId=08f114638433, content=棒棒哒~, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:41:18 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146382, encodeId=2a7c146382a4, content=以后有发展, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:41:06 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146379, encodeId=285d1463e9d1, content=这个实验不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:56 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146376, encodeId=9b671463e6ed, content=观点很有创新, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:43 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146373, encodeId=34ac1463e3c5, content=也很有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:31 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146370, encodeId=38091463e07c, content=文章很全面, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:12 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146367, encodeId=85f814636e25, content=值得学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:59 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146365, encodeId=505614636538, content=确实很有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:53 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146363, encodeId=d14014636316, content=乙酸还有这个效果, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:42 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146348, encodeId=f6f3146348fb, content=这个研究不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:38:18 CST 2016, time=2016-10-12, status=1, ipAttribution=)]
    2016-10-12 drmike

    文章很全面

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=146384, encodeId=08f114638433, content=棒棒哒~, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:41:18 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146382, encodeId=2a7c146382a4, content=以后有发展, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:41:06 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146379, encodeId=285d1463e9d1, content=这个实验不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:56 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146376, encodeId=9b671463e6ed, content=观点很有创新, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:43 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146373, encodeId=34ac1463e3c5, content=也很有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:31 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146370, encodeId=38091463e07c, content=文章很全面, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:12 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146367, encodeId=85f814636e25, content=值得学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:59 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146365, encodeId=505614636538, content=确实很有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:53 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146363, encodeId=d14014636316, content=乙酸还有这个效果, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:42 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146348, encodeId=f6f3146348fb, content=这个研究不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:38:18 CST 2016, time=2016-10-12, status=1, ipAttribution=)]
    2016-10-12 drmike

    值得学习一下

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=146384, encodeId=08f114638433, content=棒棒哒~, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:41:18 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146382, encodeId=2a7c146382a4, content=以后有发展, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:41:06 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146379, encodeId=285d1463e9d1, content=这个实验不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:56 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146376, encodeId=9b671463e6ed, content=观点很有创新, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:43 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146373, encodeId=34ac1463e3c5, content=也很有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:31 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146370, encodeId=38091463e07c, content=文章很全面, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:12 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146367, encodeId=85f814636e25, content=值得学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:59 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146365, encodeId=505614636538, content=确实很有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:53 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146363, encodeId=d14014636316, content=乙酸还有这个效果, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:42 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146348, encodeId=f6f3146348fb, content=这个研究不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:38:18 CST 2016, time=2016-10-12, status=1, ipAttribution=)]
    2016-10-12 drmike

    确实很有趣

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=146384, encodeId=08f114638433, content=棒棒哒~, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:41:18 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146382, encodeId=2a7c146382a4, content=以后有发展, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:41:06 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146379, encodeId=285d1463e9d1, content=这个实验不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:56 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146376, encodeId=9b671463e6ed, content=观点很有创新, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:43 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146373, encodeId=34ac1463e3c5, content=也很有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:31 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146370, encodeId=38091463e07c, content=文章很全面, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:12 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146367, encodeId=85f814636e25, content=值得学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:59 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146365, encodeId=505614636538, content=确实很有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:53 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146363, encodeId=d14014636316, content=乙酸还有这个效果, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:42 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146348, encodeId=f6f3146348fb, content=这个研究不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:38:18 CST 2016, time=2016-10-12, status=1, ipAttribution=)]
    2016-10-12 drmike

    乙酸还有这个效果

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=146384, encodeId=08f114638433, content=棒棒哒~, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:41:18 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146382, encodeId=2a7c146382a4, content=以后有发展, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:41:06 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146379, encodeId=285d1463e9d1, content=这个实验不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:56 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146376, encodeId=9b671463e6ed, content=观点很有创新, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:43 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146373, encodeId=34ac1463e3c5, content=也很有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:31 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146370, encodeId=38091463e07c, content=文章很全面, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:40:12 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146367, encodeId=85f814636e25, content=值得学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:59 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146365, encodeId=505614636538, content=确实很有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:53 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146363, encodeId=d14014636316, content=乙酸还有这个效果, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:39:42 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146348, encodeId=f6f3146348fb, content=这个研究不错啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161003/IMG57F1CE4724D2E2574.jpg, createdBy=c2eb1960303, createdName=drmike, createdTime=Wed Oct 12 09:38:18 CST 2016, time=2016-10-12, status=1, ipAttribution=)]
    2016-10-12 drmike

    这个研究不错啊

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