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Clinica Chimica Acta：发热血小板减少综合征患者血清细胞因子及临床特点

2019-09-13 gladiator MedSci原创

血清细胞因子
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本研究的目的探讨发热和血小板减少症的临床、微生物学和免疫学特点。<span lang="EN-US" style="font-size:12.0pt;mso-bidi-font-size:14.0pt;font-family:"Calibri","sans-serif"; mso-fareast-font-family:宋体;mso-bidi-font-f

本研究的目的探讨发热和血小板减少症的临床、微生物学和免疫学特点。

研究通过纳入不明原因发热和血小板减少症患者。采用实时PCR法检测病毒，培养法检测细菌。同时采用ELISA法检测血清细胞因子、血小板抗体IgG (PA-IgG)和幽门螺杆菌(HP)。

研究显示，74.68%的患者可检出病原菌，包括真菌/病毒/细菌感染和多重感染。但25.32%的病例中病原体不能被识别。在患者与健康对照组相比，细胞因子包括白介素(IL) 6、IL - 10 interferon-γ(IFN-γ)、血小板激活因子(PAF)参谋长和PA-IgG显著升高(P < .01或P < .05)。主成分分析提取到4组具有较强阳性预测价值的参数，表明如果将血小板参数与炎症标志物结合使用，对病情的评估将更加准确。无事件生存(EFS)(表明治疗后血小板升高的时间)在单个细菌或真菌感染患者中最高，而EFS受细胞因子和PA-IgG水平的影响。

本研究表明，免疫功能的差异可能是影响发热、血小板减少症患者预后的主要因素，而准确的病因诊断是治疗效果的重要依据。

原始出处：

Huanzhu Chen，Chun Lin，Serum cytokines and clinical features in patients with fever and thrombocytopenia syndrome

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    2020-06-02 feather78

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    2020-06-05 ms7019579240139182

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    2019-09-15 axin009

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    2019-09-15 lingaifan

    #血小板减少#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1933892, encodeId=ab9f193389286, content=<a href='/topic/show?id=7c1c2288877' target=_blank style='color:#2F92EE;'>#临床特点#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22888, encryptionId=7c1c2288877, topicName=临床特点)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3679417, createdName=feather78, createdTime=Tue Jun 02 19:41:00 CST 2020, time=2020-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809597, encodeId=a02f180959ea7, content=<a href='/topic/show?id=6cd683e603b' target=_blank style='color:#2F92EE;'>#胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83760, encryptionId=6cd683e603b, topicName=胞因子)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/017ED6AFEB45F49165298113DDC0656A/100, createdBy=84182500174, createdName=ms7019579240139182, createdTime=Fri Jun 05 12:41:00 CST 2020, time=2020-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849695, encodeId=14bb18496954e, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Wed Feb 12 00:41:00 CST 2020, time=2020-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1283631, encodeId=1afb128363146, content=<a href='/topic/show?id=2c00e784416' target=_blank style='color:#2F92EE;'>#细胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77844, encryptionId=2c00e784416, topicName=细胞因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, createdName=axin009, createdTime=Sun Sep 15 12:41:00 CST 2019, time=2019-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1302827, encodeId=a047130282ee5, content=<a href='/topic/show?id=9c72890153c' target=_blank style='color:#2F92EE;'>#血小板减少#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89015, encryptionId=9c72890153c, topicName=血小板减少)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Sun Sep 15 12:41:00 CST 2019, time=2019-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431621, encodeId=f24014316216a, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Sep 15 12:41:00 CST 2019, time=2019-09-15, status=1, ipAttribution=)]
    2019-09-15 zhouqu_8

    #综合征#

    0