Macromol Biosci:GO改性聚醚醚酮具有优良的抗菌成骨特性,或可作为骨组织工程的生物材料使用

2018-05-04 MedSci MedSci原创

聚醚醚酮(PEEK)与人类骨骼具有相似的弹性模量,因此被认为是优异的细胞相容性材料。然而,由于PEEK的生物惰性、骨传导性差以及抗菌活性弱限制了其广泛应用。在这项研究中,研究人员通过简单的浸涂方法开发了一种简便的策略来制备氧化石墨烯(GO)改性的磺化聚醚醚酮(SPEEK)(GO-SPEEK)。表征后发现GO紧密沉积在PEEK表面,这归因于PEEK和GO之间的π-π堆积相互作用。抗菌试验显示,GO-

聚醚醚酮(PEEK)与人类骨骼具有相似的弹性模量,因此被认为是优异的细胞相容性材料。然而,由于PEEK的生物惰性、骨传导性差以及抗菌活性弱限制了其广泛应用。在这项研究中,研究人员通过简单的浸涂方法开发了一种简便的策略来制备氧化石墨烯(GO)改性的磺化聚醚醚酮(SPEEK)(GO-SPEEK)。

表征后发现GO紧密沉积在PEEK表面,这归因于PEEK和GO之间的π-π堆积相互作用。抗菌试验显示,GO-SPEEK对大肠杆菌表现出优异的抑制作用。体外实验研究发现,细胞贴壁、生长、分化、碱性磷酸酶活性、定量实时聚合酶链反应分析以及钙离子沉积都表明,与PEEK和SPEEK组相比, GO-SPEEK基底可显著加速成骨细胞样MG-63细胞的增殖和成骨分化。

综上所述,该研究结果表明,GO-SPEEK在体外具有明显改善的抗菌活性和细胞相容性,表明开发的GO-SPEEK作为骨组织工程中的生物活性植入材料具有巨大潜力。

原始出处:


Ouyang L, Deng Y, et al., Graphene-Oxide-Decorated Microporous Polyetheretherketone with Superior Antibacterial Capability and In Vitro Osteogenesis for Orthopedic Implant. Macromol Biosci. 2018 May 2:e1800036. doi: 10.1002/mabi.201800036.

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06 04:59:00 CST 2018, time=2018-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400384, encodeId=a1bd140038473, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Sun May 06 04:59:00 CST 2018, time=2018-05-06, status=1, ipAttribution=)]
  5. 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target=_blank style='color:#2F92EE;'>#抗菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55688, encryptionId=c6b455688d1, topicName=抗菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Sun May 06 04:59:00 CST 2018, time=2018-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351711, encodeId=fe0c1351e1166, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun May 06 04:59:00 CST 2018, time=2018-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400384, encodeId=a1bd140038473, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Sun May 06 04:59:00 CST 2018, time=2018-05-06, status=1, ipAttribution=)]
    2019-03-08 sunylz
  6. 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  7. 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06 04:59:00 CST 2018, time=2018-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400384, encodeId=a1bd140038473, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Sun May 06 04:59:00 CST 2018, time=2018-05-06, status=1, ipAttribution=)]
    2018-05-06 wqkm

    ^_^^_^^_^

    0

  8. 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  9. [GetPortalCommentsPageByObjectIdResponse(id=1996159, encodeId=11c8199615984, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Wed Jan 09 08:59:00 CST 2019, time=2019-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070079, encodeId=cb8f20e0079dd, content=<a href='/topic/show?id=9ced1018209a' target=_blank style='color:#2F92EE;'>#骨组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101820, encryptionId=9ced1018209a, topicName=骨组织工程)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, 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level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69357, encryptionId=dc626935e20, topicName=生物材)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca282500032, createdName=1249857fm32暂无昵称, createdTime=Fri Jan 11 10:59:00 CST 2019, time=2019-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=312632, encodeId=8622312632e4, content=^_^^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Sun May 06 22:34:11 CST 2018, time=2018-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330705, encodeId=f2b71330e057d, content=<a href='/topic/show?id=c6b455688d1' 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    2018-05-06 zhaojie88
  10. 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    2018-05-06 10518094zz

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