Diabetes Care:自闭症谱系障碍(ASD)患者2型糖尿病的风险增加

2016-05-20 崔倩 译 MedSci原创

研究表明自闭症谱系障碍(ASD)和2型糖尿病(DM)之间相关的风险因素有肥胖和血脂异常。然而,ASD和2型糖尿病之间的关联仍是未知。来自中国台湾的研究人员使用了台湾全民健康保险研究数据库,该数据库在2002年至2009年招募了6122名ASD青少年和年轻成人患者,以及24488名年龄和性别匹配的对照参与者,监测直到2011年。在随访过程中研究人员对患有2型糖尿病的患者进行了鉴定。对人口统计学数据,

研究表明自闭症谱系障碍(ASD)和2型糖尿病(DM)之间相关的风险因素有肥胖和血脂异常。然而,ASD和2型糖尿病之间的关联仍是未知。

来自中国台湾的研究人员使用了台湾全民健康保险研究数据库,该数据库在2002年至2009年招募了6122名ASD青少年和年轻成人患者,以及24488名年龄和性别匹配的对照参与者,监测直到2011年。在随访过程中研究人员对患有2型糖尿病的患者进行了鉴定。

对人口统计学数据,非典型抗精神病药物使用和合并症进行了调整后,青少年(危险比[HR]2.71[95%CI 1.64-4.48])和年轻成人(HR 5.31[95%CI 2.85-9.90])ASD患者比无ASD的参与者患2糖尿病的风险要高。除第一年(HR3.03[95%CI 2.03-4.51])和前3年(HR2.62[95%CI 1.62-4.23])观测时段,敏感性分析是一致的。非典型抗精神病药物的短期(HR 1.97[95%CI 1.20-3.23])和长期(HR 1.64[95%CI 1.02-2.63])使用与后续2型糖尿病风险增加有关。

在随访过程中,青少年和年轻成人ASD患者更有可能患2型糖尿病。此外,那些使用非典型抗精神病药的ASD患者具有高风险。因此,进一步研究ASD和2型糖尿病共同的病理生理学是非常有必要的。

原始出处:

Mu-Hong Chen,Wen-Hsuan Lan,Ju-Wei Hsu,et al.Risk of Developing Type 2 Diabetes in Adolescents and Young Adults With Autism Spectrum Disorder,Diabetes Care,2016.5.20

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    2016-09-07 okhuali
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    2016-05-22 xiongke014
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    2016-05-21 lovetcm

    一些看似不相关的疾病可能在某种,背后意义上也存在关联,这是临床上面非常值得关心的话题。

    0