Arthritis Rheumatol:补充维生素D和Omega-3脂肪酸对慢性膝关节疼痛的影响

2020-06-27 xiangting MedSci原创

平均补充维生素D和n-3脂肪酸5.3年并没有减轻膝关节疼痛或改善功能或关节僵硬。

在成年人中,由骨关节炎引起的膝关节疼痛很常见。既往试验在维生素D对膝关节疼痛治疗效果方面的结果不一致,并且很少有试验研究海洋Omega-3脂肪酸(n-3 FA)。

这项关于维生素D和Omega-3的双盲、安慰剂对照试验(VITAL)通过二乘二因子设计将25,871名美国成年人随机分为维生素D和n-3 FA治疗组。在随机分组前确定了一个慢性膝关节疼痛亚组,并在基线和随访期间每年对西安大略和麦克马斯特大学关节炎指数(WOMAC; 0-100,100最差)进行评估。调整年龄和性别后,重复测量模型验证了随机治疗对随访期间WOMAC疼痛的影响。对WOMAC功能和关节僵硬重复进行分析。

共纳入1,398名参与者,这些参与者至少返回1份膝关节疼痛问卷。平均年龄为67.7岁,女性占66%,平均WOMAC疼痛为37(SD 19)。平均随访时间为5.3年(SD 0.7)。在随访期间的任一时间点,维生素D或n-3 FA组与安慰剂组的WOMAC疼痛均无差异。两种治疗方法之间的交互作用时间均无统计学意义(维生素D p=0.41,n-3 FA p=0.77)。随着时间推移,补充维生素D和n-3 FA并没有明显影响WOMAC功能或僵硬度评分。

在一个大型慢性膝关节疼痛成年患者样本中,平均补充维生素D和n-3脂肪酸5.3年并没有减轻膝关节疼痛或改善功能或关节僵硬。

原始出处:

Lindsey A. MacFarlane. The Effects of Vitamin D and Marine Omega‐3 Fatty Acid Supplementation on Chronic Knee Pain in Older U.S. Adults: Results from a Randomized Trial. Arthritis Rheumatol. 25 June 2020.

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    2020-06-29 zhaojie88
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    2020-06-27 mswert122

    #维生素D#明天就第对于正常健康人地保护中几乎看不出来,应结果是很正常的,但是对于有骨质疏松的患者可能是有用。

    0

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