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Int J Nanomedicine：早期骨愈合中锶功能化和SLActive™种植体表面的体内比较研究

2019-04-20 不详 网络

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研究表明，掺杂锶的医用品有益于骨代谢，从而改善骨愈合和骨整合。基于此，该研究的旨在评估植入物表面的性能，通过物理气相沉积（PVD）涂层（Ti-Sr-O）功能化，旨在产生可预测的锶释放。将Ti-Sr-O功能化表面与常规使用的市售表面（SLActive™）相比，在两个区域中进行骨与种植体接触（BIC％）和新骨形成（BF％）（分别ROI-I和ROI-II）。将Ti-Sr-O官能化，SLActive和4级

研究表明，掺杂锶的医用品有益于骨代谢，从而改善骨愈合和骨整合。基于此，该研究的旨在评估植入物表面的性能，通过物理气相沉积（PVD）涂层（Ti-Sr-O）功能化，旨在产生可预测的锶释放。将Ti-Sr-O功能化表面与常规使用的市售表面（SLActive™）相比，在两个区域中进行骨与种植体接触（BIC％）和新骨形成（BF％）（分别ROI-I和ROI-II）。

将Ti-Sr-O官能化，SLActive和4级钛植入物植入成年雄性新西兰白兔的股骨髁中。使用扫描电子显微镜（SEM）表征PVD磁控溅射的Ti-Sr-O表面涂层的形态和涂层厚度。评估了在模拟插入条件下涂层的锶释放和机械稳定性。此外，在插入后2周进行组织形态学BIC和BF。

组织形态学显示，Ti-Sr-O的骨形成增加，与感兴趣区域，ROI-I和ROI-II中的SLActive和4级钛相比，在距离种植体表面0-250μm和250-500μm距离处有显着差异。对于两个改性表面观察到骨与植入物接触的类似结果。

总之，该研究结果表明，纳米化的Ti-Sr-O功能化钛表面，持续释放锶，增加了种植体周围骨量，并可能有助于增强骨整合种植体的骨锚固。

原始出处：

Offermanns V, Andersen OZ, et al., A comparative in vivo study of strontium-functionalized and SLActive™ implant surfaces in early bone healing. Int J Nanomedicine. 2018 Apr 11;13:2189-2197. doi: 10.2147/IJN.S161061. eCollection 2018.

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    2019-04-29 zhzhxiang

    #active#

    0

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    2019-05-22 redcrab

    #骨愈合#

    0

  3. 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    2019-10-26 仁者大医

    #CIN#

    0

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topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Mon Jan 20 06:01:00 CST 2020, time=2020-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1702077, encodeId=2e871e0207725, content=<a href='/topic/show?id=04b9e4784aa' target=_blank style='color:#2F92EE;'>#种植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74784, encryptionId=04b9e4784aa, topicName=种植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47e130405619, createdName=huangdf, createdTime=Sun Jan 12 11:01:00 CST 2020, time=2020-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343903, encodeId=ea541343903a3, content=<a href='/topic/show?id=d512e47853f' target=_blank style='color:#2F92EE;'>#种植体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74785, encryptionId=d512e47853f, topicName=种植体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TnzXXl41yf6V8fHrDb5JdtxOgpaY6vplUhHtL8BzDh1xMtcap9H1IOlE8umxPGovhIuVkeGTY26eNUFCFaOheQ/132, createdBy=29702500197, createdName=ms6279672939590805, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460759, encodeId=2f4f1460e595a, content=<a href='/topic/show?id=668b96e72d9' target=_blank style='color:#2F92EE;'>#锶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96772, encryptionId=668b96e72d9, topicName=锶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a21b6366000, createdName=villahu, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577664, encodeId=465f15e766442, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609700, encodeId=33861609e0097, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=)]
    2020-01-20 jeanqiuqiu

    #DIC#

    0

  5. 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topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Mon Jan 20 06:01:00 CST 2020, time=2020-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1702077, encodeId=2e871e0207725, content=<a href='/topic/show?id=04b9e4784aa' target=_blank style='color:#2F92EE;'>#种植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74784, encryptionId=04b9e4784aa, topicName=种植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47e130405619, createdName=huangdf, createdTime=Sun Jan 12 11:01:00 CST 2020, time=2020-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343903, encodeId=ea541343903a3, content=<a href='/topic/show?id=d512e47853f' target=_blank style='color:#2F92EE;'>#种植体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74785, encryptionId=d512e47853f, topicName=种植体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TnzXXl41yf6V8fHrDb5JdtxOgpaY6vplUhHtL8BzDh1xMtcap9H1IOlE8umxPGovhIuVkeGTY26eNUFCFaOheQ/132, createdBy=29702500197, createdName=ms6279672939590805, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460759, encodeId=2f4f1460e595a, content=<a href='/topic/show?id=668b96e72d9' target=_blank style='color:#2F92EE;'>#锶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96772, encryptionId=668b96e72d9, topicName=锶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a21b6366000, createdName=villahu, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577664, encodeId=465f15e766442, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609700, encodeId=33861609e0097, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=)]
    2020-01-12 huangdf

    #种植#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1778999, encodeId=31c71e78999bc, content=<a href='/topic/show?id=8f881906ca' target=_blank style='color:#2F92EE;'>#active#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1906, encryptionId=8f881906ca, topicName=active)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Mon Apr 29 17:01:00 CST 2019, time=2019-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026988, encodeId=fa0e2026988d0, content=<a href='/topic/show?id=921d101668c8' target=_blank style='color:#2F92EE;'>#骨愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101668, encryptionId=921d101668c8, topicName=骨愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85aa264, 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topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Mon Jan 20 06:01:00 CST 2020, time=2020-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1702077, encodeId=2e871e0207725, content=<a href='/topic/show?id=04b9e4784aa' target=_blank style='color:#2F92EE;'>#种植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74784, encryptionId=04b9e4784aa, topicName=种植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47e130405619, createdName=huangdf, createdTime=Sun Jan 12 11:01:00 CST 2020, time=2020-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343903, encodeId=ea541343903a3, content=<a href='/topic/show?id=d512e47853f' target=_blank style='color:#2F92EE;'>#种植体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74785, encryptionId=d512e47853f, topicName=种植体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TnzXXl41yf6V8fHrDb5JdtxOgpaY6vplUhHtL8BzDh1xMtcap9H1IOlE8umxPGovhIuVkeGTY26eNUFCFaOheQ/132, createdBy=29702500197, createdName=ms6279672939590805, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460759, encodeId=2f4f1460e595a, content=<a href='/topic/show?id=668b96e72d9' target=_blank style='color:#2F92EE;'>#锶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96772, encryptionId=668b96e72d9, topicName=锶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a21b6366000, createdName=villahu, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577664, encodeId=465f15e766442, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609700, encodeId=33861609e0097, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=)]
    2019-04-22 ms6279672939590805

    #种植体#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1778999, encodeId=31c71e78999bc, content=<a href='/topic/show?id=8f881906ca' target=_blank style='color:#2F92EE;'>#active#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1906, encryptionId=8f881906ca, topicName=active)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Mon Apr 29 17:01:00 CST 2019, time=2019-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026988, encodeId=fa0e2026988d0, content=<a href='/topic/show?id=921d101668c8' target=_blank style='color:#2F92EE;'>#骨愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101668, encryptionId=921d101668c8, topicName=骨愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85aa264, 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topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Mon Jan 20 06:01:00 CST 2020, time=2020-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1702077, encodeId=2e871e0207725, content=<a href='/topic/show?id=04b9e4784aa' target=_blank style='color:#2F92EE;'>#种植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74784, encryptionId=04b9e4784aa, topicName=种植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47e130405619, createdName=huangdf, createdTime=Sun Jan 12 11:01:00 CST 2020, time=2020-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343903, encodeId=ea541343903a3, content=<a href='/topic/show?id=d512e47853f' target=_blank style='color:#2F92EE;'>#种植体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74785, encryptionId=d512e47853f, topicName=种植体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TnzXXl41yf6V8fHrDb5JdtxOgpaY6vplUhHtL8BzDh1xMtcap9H1IOlE8umxPGovhIuVkeGTY26eNUFCFaOheQ/132, createdBy=29702500197, createdName=ms6279672939590805, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460759, encodeId=2f4f1460e595a, content=<a href='/topic/show?id=668b96e72d9' target=_blank style='color:#2F92EE;'>#锶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96772, encryptionId=668b96e72d9, topicName=锶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a21b6366000, createdName=villahu, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577664, encodeId=465f15e766442, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609700, encodeId=33861609e0097, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=)]
    2019-04-22 villahu

    #锶#

    0

  8. 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topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Mon Jan 20 06:01:00 CST 2020, time=2020-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1702077, encodeId=2e871e0207725, content=<a href='/topic/show?id=04b9e4784aa' target=_blank style='color:#2F92EE;'>#种植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74784, encryptionId=04b9e4784aa, topicName=种植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47e130405619, createdName=huangdf, createdTime=Sun Jan 12 11:01:00 CST 2020, time=2020-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343903, encodeId=ea541343903a3, content=<a href='/topic/show?id=d512e47853f' target=_blank style='color:#2F92EE;'>#种植体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74785, encryptionId=d512e47853f, topicName=种植体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TnzXXl41yf6V8fHrDb5JdtxOgpaY6vplUhHtL8BzDh1xMtcap9H1IOlE8umxPGovhIuVkeGTY26eNUFCFaOheQ/132, createdBy=29702500197, createdName=ms6279672939590805, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460759, encodeId=2f4f1460e595a, content=<a href='/topic/show?id=668b96e72d9' target=_blank style='color:#2F92EE;'>#锶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96772, encryptionId=668b96e72d9, topicName=锶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a21b6366000, createdName=villahu, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577664, encodeId=465f15e766442, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609700, encodeId=33861609e0097, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=)]
    2019-04-22 ms1692212821629096

    #Medicine#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1778999, encodeId=31c71e78999bc, content=<a href='/topic/show?id=8f881906ca' target=_blank style='color:#2F92EE;'>#active#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1906, encryptionId=8f881906ca, topicName=active)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Mon Apr 29 17:01:00 CST 2019, time=2019-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026988, encodeId=fa0e2026988d0, content=<a href='/topic/show?id=921d101668c8' target=_blank style='color:#2F92EE;'>#骨愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101668, encryptionId=921d101668c8, topicName=骨愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85aa264, 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topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Mon Jan 20 06:01:00 CST 2020, time=2020-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1702077, encodeId=2e871e0207725, content=<a href='/topic/show?id=04b9e4784aa' target=_blank style='color:#2F92EE;'>#种植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74784, encryptionId=04b9e4784aa, topicName=种植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47e130405619, createdName=huangdf, createdTime=Sun Jan 12 11:01:00 CST 2020, time=2020-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343903, encodeId=ea541343903a3, content=<a href='/topic/show?id=d512e47853f' target=_blank style='color:#2F92EE;'>#种植体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74785, encryptionId=d512e47853f, topicName=种植体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TnzXXl41yf6V8fHrDb5JdtxOgpaY6vplUhHtL8BzDh1xMtcap9H1IOlE8umxPGovhIuVkeGTY26eNUFCFaOheQ/132, createdBy=29702500197, createdName=ms6279672939590805, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460759, encodeId=2f4f1460e595a, content=<a href='/topic/show?id=668b96e72d9' target=_blank style='color:#2F92EE;'>#锶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96772, encryptionId=668b96e72d9, topicName=锶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a21b6366000, createdName=villahu, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577664, encodeId=465f15e766442, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609700, encodeId=33861609e0097, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Apr 22 11:01:00 CST 2019, time=2019-04-22, status=1, ipAttribution=)]
    2019-04-22 ms3994565386320060

    #Med#

    0