Braz Oral Res:快速给予尼古丁和乙醇对牙齿移动的影响

2018-11-05 MedSci MedSci原创

本研究旨在评估急性给予尼古丁和乙醇对大鼠牙齿移动的影响。 将200只大鼠分成8组:S:盐水; N:尼古丁; E:乙醇; NE:尼古丁和乙醇; SM:牙齿运动与生理盐水; NM:牙齿运动与尼古丁; EM:乙醇与牙齿运动;和NEM:尼古丁和乙醇与牙齿运动。所有解决方案均应用了32,44或58天。在牙齿移动组中溶液施用后30天开始正畸运动(25cN)。在牙齿移动开始后2天,14天或28天对大鼠实施

本研究旨在评估急性给予尼古丁和乙醇对大鼠牙齿移动的影响。

将200只大鼠分成8组:S:盐水; N:尼古丁; E:乙醇; NE:尼古丁和乙醇; SM:牙齿运动与生理盐水; NM:牙齿运动与尼古丁; EM:乙醇与牙齿运动;和NEM:尼古丁和乙醇与牙齿运动。所有解决方案均应用了32,44或58天。在牙齿移动组中溶液施用后30天开始正畸运动(25cN)。在牙齿移动开始后2天,14天或28天对大鼠实施安乐死。使用苦味酸和抗酒石酸的酸性磷酸酶(TRAP)染色牙齿切片。使用Tukey的HSD和Games-Howell通过ANOVA比较数据。

结果显示,在牙齿移动的第28天,与SM组相比,NEM组具有较低的I型胶原百分比(p = 0.0448),并且与N组相比,S组具有较高数量的破骨细胞/μm2(p = 0.0405)。无论正畸运动的诱导如何,尼古丁和乙醇都不会影响牙齿移动速度。当未诱导牙齿移动时,尼古丁通过减少其数量来影响破骨细胞的数量。当尼古丁与乙醇结合时,它会干扰正畸运动过程中胶原纤维的成熟。

原始出处:

Araujo CM, Rocha AC, et al., Effect of acute administration of nicotine and ethanol on tooth movement in rats. Braz Oral Res. 2018 Oct 11;32:e96. doi: 10.1590/1807-3107bor-2018.vol32.0096.

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    2019-01-08 小几洁
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    2018-11-07 zhouqu_8
  4. 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createdTime=Tue Nov 06 09:09:01 CST 2018, time=2018-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351703, encodeId=c913351e037e, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=13, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Nov 06 08:53:42 CST 2018, time=2018-11-06, status=1, ipAttribution=)]
    2018-11-06 Y—xianghai

    学习了长知识

    0

  5. 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createdTime=Tue Nov 06 09:09:01 CST 2018, time=2018-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351703, encodeId=c913351e037e, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=13, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Nov 06 08:53:42 CST 2018, time=2018-11-06, status=1, ipAttribution=)]
    2018-11-06 Y—xianghai

    学习了长知识

    0

  6. 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createdTime=Tue Nov 06 09:09:01 CST 2018, time=2018-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351703, encodeId=c913351e037e, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=13, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Nov 06 08:53:42 CST 2018, time=2018-11-06, status=1, ipAttribution=)]
    2018-11-06 Y—xianghai

    学习了长知识

    0

  7. 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createdTime=Tue Nov 06 09:09:01 CST 2018, time=2018-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351703, encodeId=c913351e037e, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=13, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Nov 06 08:53:42 CST 2018, time=2018-11-06, status=1, ipAttribution=)]
    2018-11-06 Y—xianghai

    学习了长知识

    0

  8. 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    2018-11-06 Y—xianghai

    学习了长知识

    0

  9. 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    2018-11-06 Y—xianghai

    学习了长知识

    0

  10. 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time=2018-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351708, encodeId=0302351e0804, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Tue Nov 06 09:09:06 CST 2018, time=2018-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351707, encodeId=b9a8351e0770, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Tue Nov 06 09:09:01 CST 2018, time=2018-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351703, encodeId=c913351e037e, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=13, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Nov 06 08:53:42 CST 2018, time=2018-11-06, status=1, ipAttribution=)]
    2018-11-06 龙胆草

    学习谢谢分享

    0