第二十九届长城国际心脏病学会议

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2018长城会(GW-ICC) :叶平教授:甘油三酯新进展——以富含甘油三酯脂蛋白为靶点的血脂异常管理

2018-10-19 《国际循环》编辑部 《国际循环》编辑部

高甘油三酯血症(HTG)是我国最常见的血脂异常类型之一。2018年10月12日,GW-ICC年会动脉粥样硬化的基础与临床热点专场,中国人民解放军总医院叶平教授从HTG的流行病学、发病机制及临床危害入手,针对以富含甘油三酯脂蛋白(残粒脂蛋白)为靶点的血脂异常管理领域的最新进展作了专题解析。HTG概述及其危害多项流行病学调查研究显示,HTG患病率较高不容忽视。众所周知,血浆TG主要存在于富含TG的脂蛋

高甘油三酯血症(HTG)是我国最常见的血脂异常类型之一。2018年10月12日,GW-ICC年会动脉粥样硬化的基础与临床热点专场,中国人民解放军总医院叶平教授从HTG的流行病学、发病机制及临床危害入手,针对以富含甘油三酯脂蛋白(残粒脂蛋白)为靶点的血脂异常管理领域的最新进展作了专题解析。HTG概述及其危害多项流行病学调查研究显示,HTG患病率较高不容忽视。众所周知,血浆TG主要存在于富含TG的脂蛋白中,包括乳糜微粒(chylomicron,CM)、极低密度脂蛋白(VLDL)及其残粒。分析HTG产生的病理生理机制可见,内源性及外源性因素均可导致HTG的发生。其中,胰岛素抵抗、肥胖、糖尿病及代谢综合征相关的高TG则与肝脏过多合成富含TG的脂蛋白有关。HTG的危害在于其与ASCVD和急性胰腺炎密切相关。具体而言,轻中度高TG主要与ASCVD相关,而重度高TG则导致急性胰腺炎风险明显升高。遗传学研究表明,HTG与心血管疾病存在因果关系。在肝脏合成过多的富含TG的VLDL时,通过体内复杂的脂质交换,导致富含TG及胆固醇的残粒脂蛋白增高。流行病学研究显示,残粒脂蛋白胆固醇与低密度脂蛋白胆固醇(LD

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    2018-10-21 zhs3884
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    2018-10-21 chenwq12
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    2018-10-19 changjiu

    谢谢分享,学习一下谢谢

    0

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    2018-10-19 一天没事干

    很好的学习机会

    0

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