Rheumatology:症状性膝骨关节炎患者的腘动脉壁厚度与疾病进展的关系

2022-08-22 紫菀款冬 MedSci原创

研究有症状的膝骨关节炎患者的腘动脉壁厚度与膝关节软骨体积之间的关系。

目的:越来越多的证据表明血管疾病参与膝骨关节炎的发病机制。腘动脉壁厚度可作为动脉粥样硬化的替代指标。该团队研究了有症状的膝骨关节炎患者的腘动脉壁厚度与膝关节软骨体积之间的关系

方法:该前瞻性队列研究分析了176名来自一项随机安慰剂对照试验的参与者,该试验旨在研究阿托伐他汀对膝骨关节炎结构进展的影响。

参与者在基线和两年随访时接受了研究膝关节的磁共振成像(MRI)。

使用经过验证的方法用MRI测量腘动脉壁厚度和胫骨软骨体积。胫骨软骨体积损失率的上四分位被定义为快速进展

结果:基线时,腘动脉壁厚度每增加10%,与胫骨内侧软骨体积减少120.8 mm3(95%CI 5.4–236.2,p=0.04)和胫骨外侧软骨体积减少151.9 mm3(95%CI 12.1–291.7,p=0.03)有关。

纵向结果发现,校正年龄、性别、体重指数、胫骨骨面积、吸烟、剧烈体力活动以及干预组分配等因素后,腘动脉壁厚度每增加10%,胫骨内侧软骨体积损失的年发生率就增加1.14%(95%CI 0.09%-2.20%,p=0.03),胫骨内侧软骨损失的快速进展风险为2.28倍(95%CI 1.07-4.83,p=0.03)。

结论:该研究结果支持血管病理在膝骨关节炎进展中的作用针对治疗动脉粥样硬化有可能改善膝骨关节炎的预后

文献来源:

Wang Y, Pontoh EW, Hussain SM, et al. Association between popliteal artery wall thickness and structural progression in patients with symptomatic knee osteoarthritis [published online ahead of print, 2022 Aug 16]. Rheumatology (Oxford). 2022;keac469. doi:10.1093/rheumatology/keac469

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    2022-11-02 lisa438
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    2022-08-23 lmm397
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