Metabolism:肥胖和炎症代谢生物标志物与癌症死亡率之间的关联

2019-03-02 xing.T 网络

由此可见,在调整基线危险因素后,较高的基线炎症和代谢生物标志物与显著增加的癌症死亡风险相关,并且这些关联因BMI而异。癌症患者可能受益于调节炎症和代谢生物标志物的干预措施。

近日,代谢性疾病领域权威杂志Metabolism-Clinical and Experimental上发表了一篇研究文章,研究人员旨在通过肥胖状态探究炎症和代谢失调的生物标志物与癌症死亡率之间的关联。

研究人员使用卒中地理和种族差异原因(REGARDS)队列中1822名参与者的数据评估基线炎症(IL-6、IL-8、IL-10和CRP)和代谢(脂连蛋白、抵抗素和脂蛋白(a))生物标记物与癌症死亡率之间的关系。加权Cox比例风险回归被用来估算风险比和95%置信区间(CI),根据基线协变量进行调整,根据BMI(正常、超重/肥胖)进行分层来考虑生物标记物与BMI之间的显著交互作用(P<0.1)。

在平均随访8年期间,在BMI正常的参与者中,癌症死亡率与IL-6(HR为5.3; 95%CI为1.6-17.8)、CRP(HR为3.4,95%CI为1.0-11.2)和抵抗素(HR为3.7; 95%CI为1.2-11.2)最高与最低三分位数之间存在统计学显著相关性。在超重/肥胖的参与者中,IL-6与癌症死亡风险增加3倍(HR为3.5; 95%CI为1.5-8.1)有关;然而,CRP和抵抗素均未与该组的癌症死亡率显著相关。

由此可见,在调整基线危险因素后,较高的基线炎症和代谢生物标志物与显著增加的癌症死亡风险相关,并且这些关联因BMI而异。癌症患者可能受益于调节炎症和代谢生物标志物的干预措施。

原始出处:

Daniel T. Dibaba,et al.Association between obesity and biomarkers of inflammation and metabolism with cancer mortality in a prospective cohort study.Metabolism-Clinical and Experimental.2019. https://doi.org/10.1016/j.metabol.2019.01.007

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    2019-10-19 guojianrong
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    2019-03-04 闆锋旦

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