Clin Cancer Res：3期coBRIM研究| 威罗非尼+帕博西尼治疗BRAFV600+ 晚期黑色素瘤的长期随访结果

2021-10-10 Nebula MedSci原创

与单用威罗非尼相比，威罗非尼联合帕博西尼可给BRAF V600突变阳性的晚期黑色素瘤患者带来长期的临床效益

威罗非尼 (Vemurafenib) 是一种激酶抑制剂，通过抑制BRAF(丝氨酸-苏氨酸激酶)，阻止缺乏细胞因子的细胞增殖，从而起到抗肿瘤效应。2011年威罗非尼在美国获批上市，它的主要适应症是治疗BRAF V600 突变阳性的无法手术切除或转移性黑色素瘤患者。

随机3期coBRIM研究 (NCT01689519) 证实，在既往未治疗过的 BRAF V600 突变阳性晚期黑色素瘤患者中，与单用威罗非尼相比，在威罗非尼联合帕博西尼 (Cobimetinib) 可改善无进展生存期 (PFS) 和总生存期 (OS)。

本文报告了coBRIM研究的长期随访结果。

在该研究中，受试患者被1:1随机分成两组，接受口服帕博西尼（60 mg/日，连用21天，停7天）或安慰剂联合口服威罗非尼（960 mg，2/日）。

整个研究队列两组患者的OS

共495位患者被随机分至帕博西尼+威罗非尼组（n=247）或威罗非尼组（n=248）。帕博西尼+威罗非尼组和威罗非尼组分别中位随访了21.2个月和16.6个月时，中位OS分别是22.5个月（95% CI 20.3-28.8）和17.4个月（15.0-19.8）；5年OS率分别是31%和26%。帕博西尼+威罗非尼组和威罗非尼组的中位PFS分别是12.6个月（95% CI 9.5-14.8）和7.2个月（5.6-7.5）；5年PFS率分别是14%和10%。

根据基线乳酸脱氢酶水平分层的患者的OS

基线乳酸脱氢酶水平正常且肿瘤负荷低的患者以及获得完全缓解的患者的OS和PFS最长。安全性与既往报道过的一致。

综上，coBRIM研究延长随访的结果证实了与单用威罗非尼相比，威罗非尼联合帕博西尼可给BRAF V600突变阳性的晚期黑色素瘤患者带来长期的临床效益。

原始出处：

Paolo A. Ascierto, et al. 5-Year Outcomes with Cobimetinib plus Vemurafenib in BRAFV600 Mutation–Positive Advanced Melanoma: Extended Follow-up of the coBRIM Study. Clin Cancer Res October 1 2021 27 (19) 5225-5235; DOI:10.1158/1078-0432.CCR-21-0809

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2022-02-27 sunylz

#色素#

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2022-03-20 12498a1cm67暂无昵称

#BRAFV600#

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2021-12-05 crystal0562

#长期随访#

39 0
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2021-11-03 维他命

#随访结果#

66 0
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2021-10-12 zhaojie88

#BRAF#

58 0
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2021-10-12 nymo

#帕博西尼#

48 0
[GetPortalCommentsPageByObjectIdResponse(id=1680766, encodeId=9cb91680e6647, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Sun Feb 27 22:47:29 CST 2022, time=2022-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1780452, encodeId=04fb1e8045293, content=<a href='/topic/show?id=786a3663f6' target=_blank style='color:#2F92EE;'>#BRAFV600#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3663, encryptionId=786a3663f6, topicName=BRAFV600)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fa82500120, createdName=12498a1cm67暂无昵称, createdTime=Sun Mar 20 22:47:29 CST 2022, time=2022-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1967234, encodeId=21df196e234f4, content=<a href='/topic/show?id=87729e0451f' target=_blank style='color:#2F92EE;'>#长期随访#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97045, encryptionId=87729e0451f, topicName=长期随访)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4aa106, createdName=crystal0562, createdTime=Sun Dec 05 05:47:29 CST 2021, time=2021-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1818828, encodeId=6f601818828d0, content=<a href='/topic/show?id=9687984e5e3' target=_blank style='color:#2F92EE;'>#随访结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98475, encryptionId=9687984e5e3, topicName=随访结果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Nov 03 20:47:29 CST 2021, time=2021-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355033, encodeId=b0f11355033db, content=<a href='/topic/show?id=6de63659ed' target=_blank style='color:#2F92EE;'>#BRAF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3659, encryptionId=6de63659ed, topicName=BRAF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Oct 12 05:47:29 CST 2021, time=2021-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492023, encodeId=d4f0149202382, content=<a href='/topic/show?id=7d83484844c' target=_blank style='color:#2F92EE;'>#帕博西尼#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48484, encryptionId=7d83484844c, topicName=帕博西尼)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9dde8911885, createdName=nymo, createdTime=Tue Oct 12 05:47:29 CST 2021, time=2021-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559098, encodeId=9034155909813, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Tue Oct 12 05:47:29 CST 2021, time=2021-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565107, encodeId=5cb6156510edc, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Tue Oct 12 05:47:29 CST 2021, time=2021-10-12, status=1, ipAttribution=)]
2021-10-12 cqlidoudou

#黑色素#

0 0
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2021-10-12 cqlidoudou

#黑色素#

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Clin Cancer Res：3期coBRIM研究| 威罗非尼+帕博西尼治疗BRAFV600+ 晚期黑色素瘤的长期随访结果

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