JCO:干细胞移植治疗轻链淀粉样变:早期死亡率降低

2018-03-21 MedSci MedSci原创

自体干细胞移植(ASCT)用来治疗免疫球蛋白轻链(AL)淀粉样变患者的时间已超过20年。但是早期的实践经验发现治疗早期死亡率较高。JCO近期发表了一篇文章,研究20年间自体干细胞移植治疗轻链淀粉样变早期死亡率的变化。

自体干细胞移植(ASCT)用来治疗免疫球蛋白轻链(AL)淀粉样变患者的时间已超过20年。但是早期的实践经验发现治疗早期死亡率较高。JCO近期发表了一篇文章,研究20年间自体干细胞移植治疗轻链淀粉样变早期死亡率的变化。

作者回顾性分析了20年间梅奥诊所自体干细胞移植治疗AL淀粉样变的经验。672例接受过自体干细胞移植的AL淀粉样变患者根据移植时间分为3个队列(队列1,1996-2002 n=24;队列2,2003-2009 n=302,队列3,2010-2016 n=246)。整个队列的中位年龄为59岁,队列3的患者年龄稍高于其他两个队列。队列3中的累及两个以上器官的患者更少。队列3中接受移植前治疗的患者人数更多。队列3中的血液系统反应更高。整个队列的中位总生存时间为122个月且随着时间推移总生存有改善。随着时间推移,治疗相关死亡率降低。多因素分析表明,调节剂量,梅奥分期2012和血液学反应是生存的独立预后因素。

文章最后认为,自体干细胞移植是免疫球蛋白轻链淀粉样变性的有效治疗措施。总生存的改善以及治疗相关死亡率的降低表明这一疗法依然是重要的一线治疗选择。

原始出处:
M Hasib Sidiqi,Mohammed A.Aljama,et al.Stem Cell Transplantation for Light Chain Amyloidosis:Decreased Early Mortality Over Time.JCO.March 2018 doi:10.1200/JCO.2017.76.9554

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    2018-09-05 lidong40
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    2018-03-22 九九消寒

    优质资源.共同学习

    0

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    2018-03-21 明月清辉

    谢谢分享.学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1891498, encodeId=9eef18914982d, content=<a href='/topic/show?id=25b0102e2df' target=_blank style='color:#2F92EE;'>#JCO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10272, encryptionId=25b0102e2df, topicName=JCO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Wed Sep 05 19:49:00 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1744089, encodeId=f2441e4408925, content=<a href='/topic/show?id=762248e88e1' target=_blank style='color:#2F92EE;'>#干细胞移植治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48788, encryptionId=762248e88e1, topicName=干细胞移植治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=942c35279046, createdName=朱睿睿, createdTime=Tue Sep 18 11:49:00 CST 2018, time=2018-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1658856, encodeId=104d1658856f2, content=<a href='/topic/show?id=c40ce798412' target=_blank style='color:#2F92EE;'>#细胞移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77984, encryptionId=c40ce798412, topicName=细胞移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4724938298, createdName=limedical1982, createdTime=Sat Jul 28 07:49:00 CST 2018, time=2018-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1973248, encodeId=022819e32480d, content=<a href='/topic/show?id=7cc35939955' target=_blank style='color:#2F92EE;'>#早期死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59399, encryptionId=7cc35939955, topicName=早期死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Sun Mar 03 22:49:00 CST 2019, time=2019-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405159, encodeId=0e8514051598e, content=<a href='/topic/show?id=cb6e6591850' target=_blank style='color:#2F92EE;'>#淀粉样变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65918, encryptionId=cb6e6591850, topicName=淀粉样变)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2ca02527521, createdName=xjy03, createdTime=Fri Mar 23 00:49:00 CST 2018, time=2018-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298555, encodeId=0ab8298555d8, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Thu Mar 22 08:00:59 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298326, encodeId=e3df298326c3, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Mar 21 10:21:54 CST 2018, time=2018-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=298315, encodeId=6ca829831507, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Wed Mar 21 10:11:33 CST 2018, time=2018-03-21, status=1, ipAttribution=)]
    2018-03-21 九九消寒

    优质资源.共同学习

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