SCI REP:补充维生素D对心衰患者炎症标志物的影响!

2018-01-19 xing.T MedSci原创

由此可见,该研究的结果表明维生素D补充可能对心衰患者的炎性标志物具有特异性但中等的效应。

据报道维生素D具有抗炎特性;然而维生素D补充剂对心力衰竭(HF)患者炎症的影响尚未确定。近日,Scientific reports杂志上发表了一篇研究文章,研究人员进行了一项系统回顾和荟萃分析旨在评估维生素D补充剂对HF患者炎症标志物的影响。

研究人员系统地检索了MEDLINE、CINAHL、EMBASE、EBM和临床试验注册中心,检索时间从数据库成立到2017年1月25日,搜索了RCTs。两位独立评估者筛选了报告相比于安慰剂或常规护理,维生素D补充(任何形式、途径、持续时间和联合补充)对心衰患者炎症指标影响的RCT研究(无日期或语言限制)。两位评估者使用推荐、评估、发展和评估等级方法评估了偏倚风险和研究质量。

七项研究符合纳入标准,六项研究的数据可供合并(n=1012)。在荟萃分析中,补充维生素D组与对照组(n=380;P=0.04)相比,随访时肿瘤坏死因子-α(TNF-α)浓度较低。维生素D补充组与对照组之间C反应蛋白(n=231)、白细胞介素(IL)-10(n=247)或IL-6(n=154)无显著差异(所有P>0.05)。

由此可见,该研究的结果表明维生素D补充可能对心衰患者的炎性标志物具有特异性但中等的效应。

原始出处:


Alexander J. Rodriguez,et al. Effects of vitamin D supplementation on inflammatory markers in heart failure: a systematic review and meta-analysis of randomized controlled trials.Scientific reports.2018. https://www.nature.com/articles/s41598-018-19708-0

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    2018-01-21 1dd8c52fm63(暂无匿称)

    学习学习.了解了解

    0

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