Hypertension:高血压与糖尿病协同作用通过内质网应激促进肾损伤!

2017-03-28 xing.T MedSci原创

这些结果表明,糖尿病和高血压相互协同作用,通过内质网应激,促进肾功能不全和损伤。

糖尿病高血压是慢性肾脏损害的主要危险因素,占终末期肾病的70%以上。近日,血管权威杂志Hypertension上发表了一篇研究文章。在这项研究中,研究人员评估了高血压糖尿病在导致肾功能障碍和损伤中的的相互作用,以及内质网(ER)应激的作用。

研究人员在6个月大的雄性Goto-Kakizaki(GK)2型糖尿病大鼠及对照Wistar大鼠的肾动脉之间进行主动脉缩窄(AC)诱导高血压。GK大鼠和Wistar大鼠空腹血糖平均值分别为162±11和87±2毫克/分升。AC诱导的高血压发生在右肾(AC以上)而左肾血压接近正常(AC以下),两个肾脏暴露于相同的葡萄糖、循环激素和神经影响水平。

AC 8周后,GK大鼠AC(右肾)以上的血压从109±1mmHg增加到152±5mmHg,而Wistar大鼠从106±4到了141±5mmHg。GK大鼠糖尿病高血压右肾相比于GK大鼠左肾(糖尿病)和Wistar-AC大鼠右肾(高血压),其白蛋白排泄率和组织损伤明显增加。在GK-AC大鼠的糖尿病高血压肾脏中内质网应激和氧化应激指标也显著升高。用熊去氧胆酸抑制内质网应激治疗6周后可以降低血压(135±4 vs. 151±4mmHg)、白蛋白排泄、ER和氧化应激、以及肾小球损伤,同时增加高血压糖尿病肾脏的肾小球滤过率。

这些结果表明,糖尿病和高血压相互协同作用,通过内质网应激,促进肾功能不全和损伤。

原始出处:

Zhen Wang, et al. Synergistic Interaction of Hypertension and Diabetes in Promoting Kidney Injury and the Role of Endoplasmic Reticulum Stress.Hypertension. 2017. https://doi.org/10.1161/HYPERTENSIONAHA.116.08560

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createdTime=Tue Mar 28 11:04:43 CST 2017, time=2017-03-28, status=1, ipAttribution=)]
  5. 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  6. 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createdTime=Tue Mar 28 11:04:43 CST 2017, time=2017-03-28, status=1, ipAttribution=)]
    2017-03-29 绛珠草小姐

    谢谢分享,学习了。

    0

  7. 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createdTime=Tue Mar 28 11:04:43 CST 2017, time=2017-03-28, status=1, ipAttribution=)]
    2017-03-28 虈亣靌

    学习了谢谢分享

    0

  8. 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createdTime=Tue Mar 28 11:04:43 CST 2017, time=2017-03-28, status=1, ipAttribution=)]
    2017-03-28 虈亣靌

    学习了谢谢分享

    0

  9. 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    2017-03-28 淮水一方

    对疾病有指导意义!

    0

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