CCLM:比较两种丙型肝炎病毒基因分型的方法

2017-07-27 MedSci MedSci原创

丙型肝炎病毒(HCV)基因型可以作为治疗的预测指标。研究人员依次评估了两种核酸扩增试验(NAATs)和一种HCV基因型的血清学检测方法,包括Abbott RealTi me基因型II(RealTi me II),GeneMatrix限制性片段质量多态性(RFM)和Sysmex HISCL HCV Gr(HISCL Gr )。研究人员用三个检测方法检查了281个临床样本,使用HCV基因型性能亚组PH

近日,国际杂志 《Clinical Chemistry and Laboratory Medicine》在线发表一项关于比较Abbott RealTi me基因型IIGeneMatrix限制性片段多态性和Sysmex HISCL HCV Gr检测丙型肝炎病毒基因分型的研究。

丙型肝炎病毒(HCV)基因型可以作为治疗的预测指标。研究人员依次评估了两种核酸扩增试验(NAATs)和一种HCV基因型的血清学检测方法,包括Abbott RealTi me基因型IIRealTi me II),GeneMatrix限制性片段质量多态性(RFM)和Sysmex HISCL HCV GrHISCL Gr )。研究人员用三个检测方法检查了281临床样本,使用HCV基因型性能亚组PHW204SeraCare Life Sciences)评估两种NAAT的准确性。差异病例由Versant HCV v.2.0(线性探针2.0)检测法重新进行基因分型。

研究发现,使用RealTime测定的临床样品分析结果如下:基因型1b43.1%),240.2%),其它(12.5%),31.8%),41.4%)其它1个亚型,1a0.7%),60.4%)和混合(1.1%)。RealTime IIRFMP测定显示一致率为97.5%(274/281)(κ= 0.80),无显著性差异(p = 0.25)。两种测定均能够精确地按照亚型水平对板中的所有样品进行基因分型。HISCL Gr的一致率约91%(κ<0.40)与两个NAAT存在显著的统计学差异(p <0.05)。在确认测试中,RFMP测定的结果与Versant 2.0测定结果最相符。

研究表明,三种HCV检测能够对基因分型和血清分型结果提供良好的一致率。两个NAATRealTi me IIRFMP)显示出相近的性能和良好的一致性。然而,HISCL Gr测定的结果与NAAT存在显著性差异。

原始出处:

Han, Mi-Soon, Park, Yongjung, Kim, Hyon-Suk, et al.Comparison of Abbott RealTime genotype II, GeneMatrix restriction fragment mass polymorphism and Sysmex HISCL HCV Gr assays for hepatitis C virus genotyping.

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    2017-07-30 changjiu

    学习了,谢谢

    0

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    2017-07-27 中医痴

    不错的,学习了,谢谢分享!

    0

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    学习学习

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