Eur J Clin Microbiol Infect Dis:从耳朵、鼻子和咽喉(ENT)感染患者中分离细菌的药物敏感性分析

2017-04-30 AlexYang MedSci原创

最初的经验性细菌感染抗生素疗法主要基于最普遍的病原生物对药物的敏感性。最近,有研究人员就已知的引起耳朵、鼻子和咽喉(ENT)感染的6种细菌种类的药物敏感性进行了研究。在基于实验室监控的德国全国范围内的研究中,研究人员总共分析了1066份分离样本。研究发现,所有的酿脓链球菌分离样本对盘尼西林(PEN)是敏感的,表明了自然状态下的盘尼西林仍旧可以作为治疗酿脓链球菌导致的咽炎的首选药物。而对分离样本肺炎

最初的经验性细菌感染抗生素疗法主要基于最普遍的病原生物对药物的敏感性。最近,有研究人员就已知的引起耳朵、鼻子和咽喉(ENT)感染的6种细菌种类的药物敏感性进行了研究。

在基于实验室监控的德国全国范围内的研究中,研究人员总共分析了1066份分离样本。研究发现,所有的酿脓链球菌分离样本对盘尼西林(PEN)是敏感的,表明了自然状态下的盘尼西林仍旧可以作为治疗酿脓链球菌导致的咽炎的首选药物。而对分离样本肺炎链球菌,有92.9%的对PEN敏感;对流感嗜血杆菌分离样本,89.7%对阿莫西林敏感,因此,氨基青霉素仍旧保留为急性中耳炎(AOM)和急性鼻窦炎(ARS)的首先治疗药物,抗生素疗法仍旧可以考虑。与这些不同,头孢呋辛酯对治疗AOM或者ARS并不太合适,因所有的卡他莫拉菌和大于99%的流感嗜血杆菌分类为对抗生素中抗或者抗等级。另外,药物测试中,绿脓杆菌对药物的敏感性为97%-100%,除了氟喹诺酮药物(87.6%)。总之,从德国医院门诊ENT感染病人中获得的细菌样本分析表明细菌的抗药性频率较低。然而,大肠杆菌和其他病原物表现出越来越多的多种标准抗生素药物抗性,第ENT感染不合适的广谱抗生素用药必须要避免。

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    2017-10-06 sunylz
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    2017-05-25 xjy02
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