CELL STEM CELL:脂质代谢首次被发现可以控制大脑发育

2020-05-09 MedSci原创 MedSci原创

神经干/祖细胞(NSPC)活动的改变和神经发育缺陷与智力残疾有关。然而,目前我们还不清楚NSPC活性的关键调节剂,代谢的改变,是否会破坏人类神经发育,并导致可能的认知缺陷。

神经干/祖细胞(NSPC)活动的改变和神经发育缺陷与智力残疾有关。然而,目前我们还不清楚NSPC活性的关键调节剂,代谢的改变,是否会破坏人类神经发育,并导致可能的认知缺陷。

最近,在表达突变脂肪酸合成酶(FASN; R1819W)的小鼠和人类胚胎干细胞(hESCs)中,人们研究了脂质代谢和认知功能之间的联系。FASN是最近在智力障碍的人类中鉴定出的NSPC活性的代谢调节剂。

FASN R1812W变异体的纯合子小鼠,由于NSPCs中的脂质积累和随后的脂质ER应激,导致成年海马NSPC活性受损和认知缺陷。同型的FASN R1819W hESC衍生的NSPCs在胚胎二维培养物和三维前脑区域化类器官中显示出增殖率降低,与发育表型一致。

这些来自成年小鼠模型和人脑发育的体外模型的数据表明,脂质代谢的改变会影响认知障碍。

 

原始出处:

Megan Bowers et al. FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits. Cell Stem Cell (2020). DOI: https://doi.org/10.1016/j.stem.2020.04.002

 

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    2020-09-21 维他命
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    2020-05-11 neurowu
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