J Aller Cl Imm-Pract:急性哮喘患者吸入糖皮质激素疗效

2019-09-14 xing.T MedSci原创

由此可见,该分析得出的中等证据表明,SCS加高剂量ICS治疗可降低ED治疗中重度哮喘急性发作的入院风险。需要进一步研究以确定它们在ED和门诊患者中的最佳疗效。

哮喘急性发作是急诊科(ED)和随后住院的常见且重要的原因。尽管以前的综述报道在急性环境中使用高剂量吸入皮质类固醇(ICS)可以降低住院风险,但这一证据并没有改变临床实践。近日,过敏性疾病领域权威杂志Journal of Allergy and Clinical Immunology-In Practice上发表了一篇研究文章,该系统评价旨在评估ED中ICS治疗急性哮喘的疗效。

研究人员检索了PubMed、Cochrane Library和EMBASE确定了随机对照试验。该研究的主要结局为住院率。主要比较是全身性皮质类固醇(SCS)加ICS与单独使用SCS治疗的疗效。次要比较是单独使用ICS与单独使用SCS以及ICS与安慰剂相比较。

该分析共包含25项研究,涉及2733名参与者。对于主要比较,SCS加ICS与单纯SCS相比降低了入院风险,固定效应OR(95%CI)为0.73(0.57至0.94)。SCS加ICS治疗还有中度证据表明临床评分和生命体征有所改善。相对较少的研究报告了不良事件。

由此可见,该分析得出的中等证据表明,SCS加高剂量ICS治疗可降低ED治疗中重度哮喘急性发作的入院风险。需要进一步研究以确定它们在ED和门诊患者中的最佳疗效。 

原始出处:

Nethmi Kearns,et al.Inhaled corticosteroids in acute asthma: A systemic review and meta-analysis. J Aller Cl Imm-Pract. 2019.https://doi.org/10.1016/j.jaip.2019.08.051

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    2019-09-16 膀胱癌
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    2019-09-14 内科新手

    谢谢梅斯提供这么好的信息,学到很多

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