Pediatr Allergy Immunol:血清维生素D水平与嗅觉功能障碍相关,而与空气变应原致敏、鼻塞和儿童变应性鼻炎无关

2020-09-05 AlexYang MedSci原创

嗅觉功能障碍在全世界非常普遍,它会对生活质量产生不利影响。鼻炎患者的嗅觉丧失主要是由粘膜2型炎症引起的气味传递的机械性阻塞引起的。在近期发表在Pediatr Allergy Immunol期刊的一项研

嗅觉功能障碍在全世界非常普遍,它会对生活质量产生不利影响。鼻炎患者的嗅觉丧失主要是由粘膜2型炎症引起的气味传递的机械性阻塞引起的。在近期发表在Pediatr Allergy Immunol期刊的一项研究中,来自韩国CHA大学等机构的科学家测定了25-羟维生素D水平与儿童嗅觉功能障碍的严重程度的关系。

研究人员采用嗅探棒检测518例儿童(10 ~ 12岁,其中264名男孩)的嗅探阈值,并根据嗅探棒的嗅探阈值进行分组。他们还评估了血清25-羟基维生素D (25[OH]D)水平、常见的气源性致敏原特异性IgEs、鼻炎严重程度(视觉模拟评分)、四项症状总分(T4SS),以及用鼻声反射法评估了减充血前后的鼻腔通畅程度。结果显示,25(OH) D缺乏症患儿与25(OH) D≥20.0 ng/mL患儿相比,平均嗅觉阈值评分明显降低(分别为6.56±3.54和7.28±3.87,P=0.036)。嗅觉功能丧失的比例和减充血前鼻腔通畅率以及低25(OH)D水平显著相关(χ2趋势检验,趋势P =0.007)。同样地,在对混杂因素进行调整后,嗅觉丧失的儿童(第三分组)与低25(OH)D水平(aβ=-0.062,95% CI=-0.064 - -0.060, P=0.009)显著相关,这与气源性过敏原致敏无关,与低减充血前鼻腔通畅度无关。

25-羟基维生素D缺乏水平与嗅觉障碍相关

该研究表明,25-羟基维生素D与嗅觉功能障碍显著相关,而与过敏原致敏、鼻塞和变应性鼻炎无关。这一发现或将为深入了解嗅觉功能障碍发展的机制提供新见解。

原始出处:

Youn Ho Shin , Eun Kyo Ha , Ju Hee Kim et al. Serum vitamin D level is associated with smell dysfunction independently of aeroallergen sensitization, nasal obstruction, and the presence of allergic rhinitis in children. Pediatr Allergy Immunol. August 2020

 

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    2020-09-07 膀胱癌
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    2020-09-07 liuhuangbo
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1728653, encodeId=cbba1e2865306, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Aug 01 17:33:02 CST 2021, time=2021-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639598, encodeId=2b241639598a4, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Jul 06 04:33:02 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323320, encodeId=46ba1323320ac, content=<a href='/topic/show?id=5332380998f' target=_blank style='color:#2F92EE;'>#变应性鼻炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38099, encryptionId=5332380998f, topicName=变应性鼻炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a3a2500014, createdName=fmq_28614553, createdTime=Mon Sep 07 01:33:02 CST 2020, time=2020-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329413, encodeId=aa7b1329413df, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Mon Sep 07 01:33:02 CST 2020, time=2020-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361146, encodeId=e4d91361146a0, content=<a href='/topic/show?id=3e891034351c' target=_blank style='color:#2F92EE;'>#鼻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103435, encryptionId=3e891034351c, topicName=鼻塞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6779163, createdName=liuhuangbo, createdTime=Mon Sep 07 01:33:02 CST 2020, time=2020-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421331, encodeId=b191142133111, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Mon Sep 07 01:33:02 CST 2020, time=2020-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=882914, encodeId=515b88291461, content=看了这么多与<a href='/topic/show?id=5b0fe906618' target=_blank style='color:#2F92EE;'>#维生素D#</a>有关的研究,认识到维生素D 水平的重要性,所以会特意的晒晒太阳。今天早晨吃完早饭,趴在床上,听着歌晒着太阳,很惬意。, beContent=null, objectType=article, channel=null, level=null, likeNumber=222, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79066, encryptionId=5b0fe906618, topicName=维生素D)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Sat Sep 05 14:43:15 CST 2020, time=2020-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=882896, encodeId=eff8882896b2, content=看完赶紧吃了一片维生素D😭, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f435296195, createdName=ms3000000449926787, createdTime=Sat Sep 05 10:47:05 CST 2020, time=2020-09-05, status=1, ipAttribution=)]
    2020-09-05 Jessica

    看了这么多与#维生素D#有关的研究,认识到维生素D 水平的重要性,所以会特意的晒晒太阳。今天早晨吃完早饭,趴在床上,听着歌晒着太阳,很惬意。

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1728653, encodeId=cbba1e2865306, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Aug 01 17:33:02 CST 2021, time=2021-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639598, encodeId=2b241639598a4, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Jul 06 04:33:02 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323320, encodeId=46ba1323320ac, content=<a href='/topic/show?id=5332380998f' target=_blank style='color:#2F92EE;'>#变应性鼻炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38099, encryptionId=5332380998f, topicName=变应性鼻炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a3a2500014, createdName=fmq_28614553, createdTime=Mon Sep 07 01:33:02 CST 2020, time=2020-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329413, encodeId=aa7b1329413df, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Mon Sep 07 01:33:02 CST 2020, time=2020-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361146, encodeId=e4d91361146a0, content=<a href='/topic/show?id=3e891034351c' target=_blank style='color:#2F92EE;'>#鼻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103435, encryptionId=3e891034351c, topicName=鼻塞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6779163, createdName=liuhuangbo, createdTime=Mon Sep 07 01:33:02 CST 2020, time=2020-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421331, encodeId=b191142133111, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Mon Sep 07 01:33:02 CST 2020, time=2020-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=882914, encodeId=515b88291461, content=看了这么多与<a href='/topic/show?id=5b0fe906618' target=_blank style='color:#2F92EE;'>#维生素D#</a>有关的研究,认识到维生素D 水平的重要性,所以会特意的晒晒太阳。今天早晨吃完早饭,趴在床上,听着歌晒着太阳,很惬意。, beContent=null, objectType=article, channel=null, level=null, likeNumber=222, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79066, encryptionId=5b0fe906618, topicName=维生素D)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Sat Sep 05 14:43:15 CST 2020, time=2020-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=882896, encodeId=eff8882896b2, content=看完赶紧吃了一片维生素D😭, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f435296195, createdName=ms3000000449926787, createdTime=Sat Sep 05 10:47:05 CST 2020, time=2020-09-05, status=1, ipAttribution=)]
    2020-09-05 ms3000000449926787

    看完赶紧吃了一片维生素D😭

    0

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