Chest:类风湿性关节炎一系列间质性肺部异常的基线特征和进展

2020-05-17 xiangting MedSci原创

病变位于胸膜下和基线ILA/ILD范围大是与进展相关的危险因素。

高达60%的类风湿性关节炎(RA)患者中可见间质性肺异常(ILA)和间质性肺病(ILD),其中一些逐渐进展会对死亡率产生重要影响。更好地表征进展性间质改变以及识别与进展相关的危险因素有助于早期治疗和改善预后。这项研究旨在探讨与RA-ILD进展相关的基线特征。

这是一项回顾性研究,对2014-16年间成年RA患者的胸部CT扫描进行评估,评估其间质的变化,并根据临床病历进一步细分为ILA和ILD。肉眼确定进展,随后进行半定量。

有系列间质变化的患者(293人中有64人)是年龄较大的男性吸烟者,并较少使用生物制剂/小分子疾病改善抗风湿药。ILA占44%,其中46%因非肺部指征接受胸部CT检查。在56例有序贯CT的ILA/ILD患者中,38%在4.4年内有影像学进展的证据。29%的ILA出现进展。进展性ILA/ILD的危险因素包括病变位于胸膜下和基线受累多。

293例接受CT检查的RA患者中,有22%存在间质性改变,其中一半在进行影像检查时有呼吸系统不适。38%出现影像学进展。在进展性ILA患者中,有一半因为非肺部指征接受了基线CT检查。病变位于胸膜下和基线ILA/ILD范围大是与进展相关的危险因素。未来需要RA-ILA的前瞻性纵向研究。

原始出处:

Leticia Kawano-Dourado. Baseline Characteristics and Progression of a Spectrum of Interstitial Lung Abnormalities and Disease in Rheumatoid Arthritis. Chest. 16 May 2020.

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    2020-11-07 Smile2680
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    2020-05-19 lmm397
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