Diabetologia:中科院上海营养健康所:中老年人应注意这一指标,或影响糖尿病发病

2022-01-24 MedSci原创 MedSci原创

近几十年来,我国居民的肥胖、代谢综合征及糖尿病等心血管代谢性疾病的患病率快速攀升,威胁居民健康。

近几十年来,我国居民的肥胖、代谢综合征糖尿病等心血管代谢性疾病的患病率快速攀升,威胁居民健康。健康的生活方式是国际公认的预防和控制这类疾病经济有效的方法,但目前人们对其在疾病过程中的复杂影响和调控路径认识有限。

近年来,包括脂质组在内的代谢组学技术的快速发展,为发现疾病早期的生物标记物、阐释疾病发生发展相关的代谢通路和调控因素提供了契机。在诸多脂质分子中,甘油磷脂(glycerophospholipid, GPLs)与糖尿病、代谢综合征的关系受人瞩目。

然而相关的前瞻性队列研究有限,尤其是在亚洲人群中的研究十分匮乏。为此,来自中国科学院上海营养与健康研究所与中国科学院分子细胞科学卓越创新中心组合作开展了相关研究,结果发表在Diabetologia杂志上。

该研究包括1877名50-70岁的中国社区居民(751名男性和1126名女性),基线时没有糖尿病,并随访6年。通过使用高通量靶向脂质组学,对基线时血浆中总共160种GPL进行了量化。对数泊松回归被用来评估GPLs和糖尿病发病率之间的关联。

在6年的随访中,499名参与者(26.6%)患上了糖尿病。经多变量调整后,8种GPLs与发生的糖尿病呈正相关(RRper SD 1.13-1.25)。其中,包括五种新的GLPs,即磷脂酰胆碱(PC)、溶血磷脂酰胆碱(LPC)和磷脂酰乙醇胺(PE),以及三种已报道的GPLs。

在网络分析中,含有PC的模块与发生的糖尿病风险增加16%正相关(RRper SD 1.16)。值得注意的是,三个与糖尿病相关的PC和PE不仅与新生脂肪生成(DNL)途径中的脂肪酸有关,特别是16:1n-7(S相关系数=0. 35-0.62,),而且还与精制谷物含量高、鱼类、乳制品和豆制品含量低的不健康饮食模式有关(|因子负荷| ≥0.2)。

当按体力活动水平分层时,8个GPLs和PC模块与发病糖尿病的关联在体力活动水平较低的参与者中比在体力活动水平居中和较高的参与者中要强。

综上,我国人群中,8个GPLs,特别是与DNL途径相关的PC,与发生的糖尿病呈正相关。这些关联在体育活动水平低的参与者中最为突出。

 

参考文献:

Associations of plasma glycerophospholipid profile with modifiable lifestyles and incident diabetes in middle-aged and older Chinese. Diabetologia 65, 315–328 (2022). https://doi.org/10.1007/s00125-021-05611-3

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    2022-08-25 一叶知秋
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    2022-06-04 gous

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JCEM:湘雅二院赵水平等研究发现辅酶A可有效降低血浆甘油三脂水平

为了评估在伴有中度血脂异常的中国患者,天然降血脂化合物辅酶A(CoA)的降脂疗效和临床安全性,来自中南大学湘雅二院心脏科的赵水平教授及其团队进行了一项研究,该研究发现CoA可有效降低血浆甘油三脂(TG)水平,并且没有明显的不良反应。该研究发表在2013年2月的美国《临床内分泌代谢杂志》(The journal of clinical endocrinology & metabolism)上