供体来源的间充质干细胞治疗慢性非结核分枝杆菌感染,临床前研究效果显著!

2021-05-06 Allan MedSci原创

在美国,有超过100000人患有慢性非结核性分枝杆菌肺部感染。这些感染难以治疗,并且会严重损害患者的生活质量和生存率。

在美国,有超过100000人患有慢性非结核性分枝杆菌肺部感染。这些感染难以治疗,并且会严重损害患者的生活质量和生存率。非结核分枝杆菌(NTM)是机会性细胞内细菌,在环境中无处不在,在免疫系统受损的个体中会成为致病菌,包括囊性纤维化患者(CF)、支气管扩张患者、肺泡蛋白沉着症或慢性阻塞性肺疾病(COPD)患者。NTM感染在老年人中也很普遍(年龄> 60岁,每100000人中有13.9例)。NTM感染的治疗包括基于大环内酯类的多药鸡尾酒疗法,该疗法通常与毒性相关,且复发率高(12%-58%)。

鸟复合分枝杆菌(MAC)是NTM的一种,是非CF支气管扩张、COPD和衰老个体中最常见的NTM分离株。常见的MAC包括M. avium和M.intracellulare。

人间充质干细胞(hMSCs)是抗微生物活性的动态仓库。先前研究表明,hMSC在体外和体内均具有抗微生物、抗炎和抗纤维化的潜力,同时hMSC可提高抗生素的有效性,因此减少根除细菌所需的剂量。本研究使用慢性NTM感染的体内和体内模型来评估hMSC的潜在治疗用途,这些数据证明了hMSC具有令人信服的多功能性,以治疗慢性NTM感染。

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hMSC细胞和上清具有抗结核分枝杆菌的效力

 

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hMSC增强抗生素抗非结核分枝杆菌的能力

 

原始出处:

https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.20-0521

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    2021-07-02 feather85
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    2021-05-09 独孤立克

    干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1942719, encodeId=8b711942e1900, content=<a href='/topic/show?id=42a831e76af' target=_blank style='color:#2F92EE;'>#分枝杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31776, encryptionId=42a831e76af, topicName=分枝杆菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Mon Dec 27 18:25:52 CST 2021, time=2021-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631895, encodeId=56d4163189597, content=<a href='/topic/show?id=bd782682e3a' target=_blank style='color:#2F92EE;'>#供体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26827, encryptionId=bd782682e3a, topicName=供体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c9ed21829086, createdName=feather85, createdTime=Fri Jul 02 07:25:52 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815562, encodeId=2ab41815562e2, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sat Mar 26 20:25:52 CST 2022, time=2022-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1025555, encodeId=5111102555552, content=干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=独孤立克, createdTime=Sun May 09 09:25:52 CST 2021, time=2021-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1254393, encodeId=3a4812543932c, content=<a href='/topic/show?id=f30ae86297d' target=_blank style='color:#2F92EE;'>#结核#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78629, encryptionId=f30ae86297d, topicName=结核)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Sat May 08 00:25:52 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1439765, encodeId=57ba1439e6517, content=<a href='/topic/show?id=89d9e86326c' target=_blank style='color:#2F92EE;'>#结核分枝杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78632, encryptionId=89d9e86326c, topicName=结核分枝杆菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat May 08 00:25:52 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440669, encodeId=877b1440669b3, content=<a href='/topic/show?id=eee09960969' target=_blank style='color:#2F92EE;'>#非结核分枝杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99609, encryptionId=eee09960969, topicName=非结核分枝杆菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25bc4750258, createdName=zywlvao, createdTime=Sat May 08 00:25:52 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047340, encodeId=b46c104e34005, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu May 06 12:25:52 CST 2021, time=2021-05-06, status=1, ipAttribution=)]
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    2021-05-06 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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入住ICU的结核病患者的生存率在过去十年中没有改善,死亡率仍然很高。延误结核病治疗与较高的医院死亡率相关。