诺华的IL-17A单抗Cosentyx在银屑病关节炎III期研究中显著减轻滑膜炎

2020-11-06 MedSci原创 MedSci原创

治疗第12周时,与安慰剂相比,Cosentyx明显减轻了患者的滑膜炎严重水平,达到了研究的主要终点。

诺华IIIb期临床研究ULTIMATE显示其白细胞介素17A(IL-17A)单抗Cosentyx(secukinumab)在活动性银屑病关节炎(PsA)患者中显著减轻了患者的早期滑膜炎。

Full text] Secukinumab for rheumatology: development and its potential  place in t | DDDT

图片来源:https://www.dovepress.com/secukinumab-for-rheumatology-development-and-its-potential-place-in-th-peer-reviewed-fulltext-article-DDDT

该研究中患者滑膜炎或关节内膜炎症,是通过Power Doppler超声检查(PDUS)(一种先进且灵敏的成像技术)进行评估。

研究结果显示,治疗第12周时,与安慰剂相比,Cosentyx明显减轻了患者的滑膜炎严重水平,达到了研究的主要终点。

在银屑病关节炎中,滑膜炎可导致关节损伤,如果不及时治疗,这种损伤是不可逆的。除减少滑膜炎外,Cosentyx先前已被证明可以长期抑制PsA,从而减轻关节损伤并有助于改善患者的预后。

研究人员表示说:“使用灵敏的成像技术来判断PsA患者体内滑膜炎和关节炎水平,是一项新突破。”

原始出处:

http://www.pharmatimes.com/news/novartis_cosentyx_reduces_synovitis_in_new_psoriatic_arthritis_study_1356011

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time=2020-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508132, encodeId=2e94150813263, content=<a href='/topic/show?id=8b7751152d' target=_blank style='color:#2F92EE;'>#Cosentyx#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5115, encryptionId=8b7751152d, topicName=Cosentyx)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79929938099, createdName=isabellayj, createdTime=Sun Nov 08 05:26:33 CST 2020, time=2020-11-08, status=1, ipAttribution=)]
    2020-11-16 12148e5fm50暂无昵称

    👍

    0

  5. 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time=2020-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508132, encodeId=2e94150813263, content=<a href='/topic/show?id=8b7751152d' target=_blank style='color:#2F92EE;'>#Cosentyx#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5115, encryptionId=8b7751152d, topicName=Cosentyx)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79929938099, createdName=isabellayj, createdTime=Sun Nov 08 05:26:33 CST 2020, time=2020-11-08, status=1, ipAttribution=)]
    2020-11-08 lmm397
  6. 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  7. 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    2020-11-08 fzwish20000
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    2020-11-08 pcw106
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