Brit J Cancer:女性生殖因素与绝经后女性肺癌风险

2020-03-17 MedSci原创 MedSci原创

在绝经后的妇女中,没有发现生殖因素与肺癌风险之间有统计学意义上关联。

绝经后妇女的生殖因素和激素使用可能影响患肺癌的风险,但流行病学的证据并不一致。

近日,肿瘤领域权威杂志British Journal of Cancer上发表了一篇研究文章,研究人员利用韩国国家健康保险系统数据库确定了4775398名年龄超过40岁的绝经后妇女,她们在2009年1月1日至2014年12月31日期间接受了心血管健康和癌症筛查。有关生殖因素的信息是通过自填问卷获得的。肺癌的风险是用Cox比例风险回归模型估计的。

在平均4.4年的随访中,16556名妇女(15223名不吸烟者)被诊断为肺癌。初潮年龄(初潮年龄≥18 vs. ≤14,调整后风险比[aHR]为1.03;95%置信区间[CI]为0.98-1.09)或绝经年龄(绝经年龄≥55 vs. <40;aHR为1.02,95%可信区间为0.91-1.14)对肺癌风险无显著影响。此外,儿女数量、哺乳喂养时间长短和使用激素替代疗法与肺癌风险无关。

由此可见,在绝经后的妇女中,没有发现生殖因素与肺癌风险之间有统计学意义上的关联。

原始出处:

Keun Hye Jeon,et al.Female reproductive factors and the risk of lung cancer in postmenopausal women: a nationwide cohort study.British Journal of Cancer.2020.https://www.nature.com/articles/s41416-020-0789-7

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    2020-03-19 zxxiang