Mol Nutr Food Res:茶皂素或可改善机体肥胖相关的认知功能障碍

2015-10-06 sunshine 译 MedSci原创

绿茶或可改善机体肥胖相关的认知功能障碍在未来,医生或许会为你开一张一杯茶的处方以减少机体肥胖相关的认知功能损伤。动物实验研究表明,茶皂素或可用于预防神经退行性变,并可改善肥胖相关的认知功能损伤。 精神疾病(如精神分裂症)患者的肥胖与代谢问题发病率很高。精神失常本身可导致机体肥胖的发生,也可因为精神失常患者服用药物的的副作用或不健康的生活方式引起机体代谢紊乱导致肥胖的发生。以上两种原因都可导致机体的

在未来,医生或许会为你开一张一杯茶的处方以减少机体肥胖相关的认知功能损伤。

精神分裂症研究机构的一项动物实验研究表明,补充茶皂素或可预防神经退行性变,并可改善肥胖相关的认知功能损伤。
 
精神疾病(如精神分裂症)患者的肥胖与代谢问题的发病率很高。精神失常本身可导致机体肥胖的发生,或是因为精神失常患者服用药物的的副作用或不健康的生活方式引起机体代谢紊乱导致肥胖的发生。以上两种原因都可导致机体的认知功能损伤,而Dr Yinghua Yu和Prof Xu-Fung Huang正努力探索可改善机体认知功能损伤方法。

肥胖患者的大脑中瘦素的水平较低,只有在机体进食的时候激素才会停止饥饿感,称为瘦素抵抗。瘦素也有益于大脑的学习和记忆功能。

脑源性神经营养因子(BDNF)可促进大脑新的神经元生长,对大脑的学习和记忆也很重要。高脂肪饮食可导致肥胖的发生,降低脑内BDNF的水平,不过瘦素可逆转此改变。

因此,瘦素是大脑保持机体特定的认知功能的重要组成部分,也是机体保持正常体重的重要组成部分,这使得瘦素成为很许多研究治疗的靶点。

本研究发现,茶皂素不仅可改善大脑中的瘦素信号,还可改善瘦素引起的BDNF的生长水平。这或许有助于减少肥胖相关的认知功能下降。

然而需要注意的是,通过经常饮茶摄入的茶皂素的剂量明显低于本研究中茶皂素的剂量,因此仍需要临床试验研究以确定人体摄入茶皂素的最佳剂量,以及长期摄入茶皂素的毒性风险。

原始出处:

Yu Y, Wu Y, Szabo A, Wang S, Yu S, Wang Q, Huang XF.Teasaponin improves leptin sensitivity in the prefrontal cortex of obese mice.Mol Nutr Food Res. 2015 Aug 28. 


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    2015-10-08 hbwxf
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