Circulation:过去50年心脏恶性肿瘤调查——长达40年的研究

2015-10-27 Seven L 译 MedSci原创

研究者对超过500名患者进行了长达40年的研究,调查原发性心脏恶性肿瘤 (PMCTs)的发病率、组织病理学、人口统计学和生存率等资料。该研究纳入了在1973-2011年诊断为PMCTs的患者,研究者描述了该疾病的病理学特征和发病率,同时将其与类似病理学改变但是心脏以外病变的患者进行比较其特征和生存率。该研究共纳入7,384,580名患者,其中551 (0.008%)名为PMCTs。该疾病的整体发生

研究者对超过500名患者进行了长达40年的研究,调查原发性心脏恶性肿瘤 (PMCTs)的发病率、组织病理学、人口统计学和生存率等资料。

该研究纳入了在1973-2011年诊断为PMCTs的患者,研究者描述了该疾病的病理学特征和发病率,同时将其与类似病理学改变但是心脏以外病变的患者进行比较其特征和生存率。

该研究共纳入7,384,580名患者,其中551 (0.008%)名为PMCTs。该疾病的整体发生率为34例/ 1亿人,随着时间的推移,该疾病发生率呈上升趋势:25.1 (1973-1989)、30.2 (1990-1999) 、46.6 (2000-2011)。

发病人群中女性占54.1%,白种人占78.6%,平均诊断年龄为50岁。最常见的PMCTs为肉瘤(n=357, 64.8%),其次是淋巴瘤 (n=150, 27%),然后间皮瘤 (n=44, 8%)。绝大部分患者经病理活检确诊(96.8%)。

关于治疗,有19%的患者接受了放疗,44%的患者实施了手术治疗。平均随访80个月后,其中有43名患者死亡。1、3、5年生存率分别为46%、22%、17%;并且随时间推移,生存率也在上升:32%, 17%, 14% (1973-1989) -50%, 24%, 19% (2000-2011) (p=0.009)。

心脏肉瘤和间皮瘤是最常见的致死性 PMCTs,其1、3、5年生存率分别为 47%, 16%, 11%以及51%, 26%, 23%,淋巴瘤为59%、41%、34%(log rank test p<0.001)。同样是肉瘤、淋巴瘤,在心脏发病的比心外患者不仅更年龄,生存率也更糟糕(p<0.001)。

研究结果表明,虽然PMCTs发生率很低,不过其预后很差。在过去的50年时间里,PMCT不管是发生率还是生存率均呈上升趋势。并且与同组织变化的心外肿瘤相比,PMCTs患者通常更年轻,生存情况更糟糕。

原始出处:

Oliveira GH, Al-Kindi SG,et al.Characteristics and Survival of Malignant Cardiac Tumors: A 40-Year Analysis of Over 500 Patients.Circulation. 2015 Oct 14.


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    2016-01-28 lyh994

    zan

    0

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    2016-01-13 Lynee劲飞扬

    给力

    0

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    2015-10-28 梦想天空

    0

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    2015-10-28 IIIi

    很多疾病都有年轻化趋势

    0

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