J Food Sci:膳食补充发酵的大豆或可有效预防骨质疏松

2019-02-09 MedSci MedSci原创

骨质流失是骨质疏松症的临床前阶段,它随着衰老而自然发生,并增加老年人骨折的风险。既往研究已经揭示了大豆对由于其异黄酮含量导致的骨质流失的有益作用。发酵改变大豆异黄酮含量,即异黄酮糖苷水解成糖苷配基。然而,尚不清楚这些改变如何影响大豆对骨质流失的预防作用。在这项研究中,我们喂养衰老加速小鼠SAMP6,这是一种老年性骨质减少的模型,用相同剂量的非发酵大豆(NS)或发酵大豆,Doenjang(DJ)喂养

骨质流失是骨质疏松症的临床前阶段,它随着衰老而自然发生,并增加老年人骨折的风险。既往研究已经揭示了大豆对由于其异黄酮含量导致的骨质流失的有益作用。发酵改变大豆异黄酮含量,即异黄酮糖苷水解成糖苷配基。然而,尚不清楚这些改变如何影响大豆对骨质流失的预防作用。

在这项研究中,我们喂养衰老加速小鼠SAMP6,这是一种老年性骨质减少的模型,用相同剂量的非发酵大豆(NS)或发酵大豆,Doenjang(DJ)喂养18周。结果显示,补充有DJ的小鼠显示出比骨质减少的SAMP6小鼠老对照(OC)高1.13倍的骨密度和1.06倍的相对骨长,而补充NS的小鼠没有显著改善。通过改善骨形成和减少破骨细胞生成,补充DJ有效地防止了骨质减少模型中的骨丢失。此外,我们发现DJ通过BMP2-Smad-Runx2信号传导增加SAMP6小鼠的成骨作用。

总之,这些结果表明,发酵过程可以增强大豆的骨质流失,而膳食补充发酵的大豆可能有益于骨骼健康。

原始出处:

Nirmala FS, Lee H, et al., Fermentation Improves the Preventive Effect of Soybean Against Bone Loss in Senescence-Accelerated Mouse Prone 6. J Food Sci. 2019 Feb;84(2):349-357. doi: 10.1111/1750-3841.14433.

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    2019-02-15 zwjnj2

    学习学习努力学习

    0

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    2019-02-14 yjs木玉

    好好好好好好

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    2019-02-10 zhaojie88
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    2019-02-10 Eleven17