Atherosclerosis:原发性高血压伴发代谢综合症影响心血管事件的发生

2015-11-23 phylis 译 MedSci原创

背景:高血压患者普遍存在代谢综合症(MS)。然而,MS对动脉粥样硬化事件的影响是否超过个别组成对心血管事件的影响尚有争议。研究者旨在评估高血压人群中MS对不良心血管事件的独立预测作用。方法:研究者随访了2176名原发性高血压患者,这些患者不存在心血管疾病,随访时间中位数为40个月。对所有受试者进行至少一年一次随访。根据更新的NCEP III 标准定义MS。主要终点为卒中发生,冠心病(CAD)发生或

背景:高血压患者普遍存在代谢综合症(MS)。然而,MS对动脉粥样硬化事件的影响是否超过个别组成对心血管事件的影响尚有争议。研究者旨在评估高血压人群中MS对不良心血管事件的独立预测作用。

方法:研究者随访了2176名原发性高血压患者,这些患者不存在心血管疾病,随访时间中位数为40个月。对所有受试者进行至少一年一次随访。根据更新的NCEP III 标准定义MS。主要终点为卒中发生、冠心病(CAD)发生或者两者共同发生。

结果:基线时,819名高血压患者存在MS(37.6%)。与无MS组相比,MS组发生难治性高血压的可能性增加(18.4%vs10.6%)。在整个随访期间,复合终点的发生率为3.1%(69名)。与对照组相比,MS患者更容易发生严重不良心血管事件(MACE)(3.7%vs1.9%)。然而,MS是MACE的独立预测因子。MS独立于个别危险因素可预测MACE的发生。

结论:MS预测高血压患者不良心血管事件的发生。在高血压人群中,MS可能使得对未来心血管风险的预测更加准确,并且能够为一级预防提供更有效的措施。

原文出处:

Georgiopoulos G, Tsioufis C, Tsiachris D,et al. Metabolic syndrome, independent of its components, affects adversely cardiovascular morbidity in essential hypertensives.Atherosclerosis. 2015,Nov 6.


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    2015-11-25 lsndxfj

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