Alzheimer Dementia:锥体外系症状可有效预测痴呆风险

2021-04-22 Freeman MedSci原创

锥体外系症状可有效预测痴呆风险

锥体外系症状(EPS)是阿尔茨海默病(AD)的一个常见特征。与非痴呆老人相比,患有AD的人更有可能出现EPS,有EPS的认知障碍老人更有可能发展成AD,而且AD患者中EPS的流行率在疾病发生后随着时间推移而增加。从预后的角度来看,AD患者中EPS的存在与较差的临床结果有关。在横断面研究中,AD患者中EPS的存在与较差的认知和功能表现有关,在纵向分析中,EPS已被证明可预测更快速的认知衰退、认知和功能障碍的风险升高,以及死亡率和需要全时护理和更高的护理费用。

基于一个种族多样化的社区队列,发现EPS预示着更快的认知衰退率,对EPS和AD结果的纵向研究都是在临床转诊和大部分种族同质或主要是白人人群中进行的。以前的研究结果显示,基线存在的EPS和时变(time-varying)存在的EPS(在随访期间捕获EPS的发病情况)预示着死亡、认知、功能和依赖性终点的时间更短,认知下降的速度更大。意大利的一项基于诊所的回顾性研究发现,AD发病时的EPS预示着2年内认知能力下降更快。由于美国的老龄化人口越来越多,需要进一步研究以更好地了解EPS对多民族和社区居住人口的AD疾病过程的预后价值。

藉此, 哥伦比亚大学的Anton J. Kociolek等人,前瞻性地调查了142名多民族社区居住的痴呆症患者,探究EPS与临床意义上的痴呆结果之间的关系。

核心的假设:与那些没有EPS的人相比,基线上有中度EPS的人的死亡风险、认知和功能障碍的增加以及对全职护理的需求增加会明显增加。
进一步假设,这些结果的相对风险会因EPS状态而在其他风险因素的亚组中有所不同。

通过将基线EPS作为预测因素,对死亡率、认知(MMSE≤10)、功能(Blessed Dementia Rating Scale≥10)和依赖性(需要全时护理)终点进行调整后的Cox模型分析。

他们发现:37名参与者(26.06%)在基线上有EPSEPS预测了更快的死亡时间(危险比[HR]=2.76)和功能终点(HR=3.88),但没有预测认知和依赖性终点。
但没有发现种族、年龄、性别、教育或脂蛋白Eε4多态性相互影响的证据。

这个研究的重要意义在于,间接证实了以前基于白人的研究,但需要进一步探究以更好地了解EPS在AD中的病理作用。

 

原文出处:

Kociolek, Anton J., et al. "Extrapyramidal signs and Alzheimer's disease prognosis in a multiethnic, community‐based sample of demented elders." _Alzheimer's & Dementia_ (2021).

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    2021-04-22 梅斯小助手

    三人行,必有我师。 #梅斯医学科研互助群# 欢迎您的加入,添加【梅斯医学科研助手WeChat:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1717999, encodeId=004a1e17999bb, content=<a href='/topic/show?id=8f0658433a' target=_blank style='color:#2F92EE;'>#dementia#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5843, encryptionId=8f0658433a, topicName=dementia)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307e32501717, createdName=linlin2323, createdTime=Tue Sep 28 12:52:06 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815083, encodeId=5c501815083d0, content=<a href='/topic/show?id=321596e49d3' target=_blank style='color:#2F92EE;'>#锥体外系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96749, encryptionId=321596e49d3, topicName=锥体外系)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Tue Jan 18 01:52:06 CST 2022, time=2022-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316776, encodeId=02781316e76b5, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Fri Apr 23 20:52:06 CST 2021, time=2021-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=959343, encodeId=db9595934319, content=三人行,必有我师。 <a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a> 欢迎您的加入,添加【梅斯医学科研助手WeChat:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/240d3ae7a8e8452d9f49793c3923ad60/78defa70ab2947c28066b378f1117648.jpg, createdBy=fa315475285, createdName=梅斯小助手, createdTime=Thu Apr 22 11:20:31 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048770, encodeId=333b1048e70be, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Thu Apr 22 08:52:06 CST 2021, time=2021-04-22, status=1, ipAttribution=)]
    2021-04-22 junJUN

    老年人痴呆何药可用??

    0

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