Ther Apher Dial:改善充血性心力衰竭和心肾综合征患者的生存率,CVVH是否比SCUF有效?

2017-06-29 MedSci MedSci原创

连续性静脉-静脉血液滤过(CVVH)可以通过循环去除细胞因子,对炎症反应进行调控,从而改善心力衰竭(HF)患者的心功能。因此我们假设,与缓慢连续超滤(SCUF)相比较,对患有心肾综合征的患者进行CVVH治疗可有效降低患者的死亡风险。

连续性静脉-静脉血液滤过(CVVH)可以通过循环去除细胞因子,对炎症反应进行调控,从而改善心力衰竭(HF)患者的心功能。因此我们假设,与缓慢连续超滤(SCUF)相比较,对患有心肾综合征的患者进行CVVH治疗可有效降低患者的死亡风险。

这是一项为期24个月的前瞻性纵向随访研究。总共有120名来自重症监护室患有1型或2型心肾综合征的患者被纳入研究。

CVVH组和SCUF组分别有54名和23名患者生存。对患有心肌病的患者来说,CVVH组平均生存时间大于SCUF组。对患有心肌病和尿量<10 ml/h的患者进行比较,CVVH组平均存活时间明显延长。这是第一次对心肾综合征患者进行不同类型血液净化治疗(CVVH vs. SCUF)间生存率的对比分析。接受CVVH治疗的患者生存率较长,这一点在心肌病患者表现更为突出,并能显着改善患者每小时尿量。心肌病患者生存率增加的原因可能是因为CVVH的滤过分数较大,可以有效地滤过细胞因子,同时CVVH模式的治疗持续时间较长。

缓慢连续超滤仍然是慢性心力衰竭患者治疗的选择,但对患有心肾综合征的患者来说,SCUF作用比起CVVH来说逊色多了。

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    2017-07-02 siiner
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    2017-07-01 makuansheng
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