J Hypertens:老年人体位性低血压与认知功能、脑损伤或脑血流特征无关!

2018-01-27 xing.T MedSci原创

由此可见,在老年人中,体位性低血压的存在与认知能力下降无关。此外,在潜在的脑血管机制中也没有发现差异。

体位性低血压与认知功能减退有关,尤其是老年人,可能是由于脑血流量减少所致。近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,该研究旨在探讨老年人体位性低血压是否与认知功能障碍有关,如果是,这种相关性是否由脑血管损伤和/或脑血流减少所介导。

四百二十名参与老年人停止抗高血压治疗(DANTE)研究的受试者(平均年龄为81岁,所有受试者服用降压药物,以及存在轻度认知功能障碍),并从巢式DANTE MRI亚组研究获得了214名参与者的MRI扫描数据。体位性低血压是指站立后3分钟内收缩压下降至少20mmHg和/或舒张压至少降低10mmHg。认知功能使用六个认知测试进行评估,包括认知、记忆功能、执行功能和精神运动速度。研究人员通过MRI来评估脑血管损伤和脑血管血流量。

研究人员发现体位性低血压发生率为47%(n=199)。与无体位性低血压者相比,体位性低血压患者在认知功能、脑小血管病变特征、显微结构完整性、脑血流等方面无明显差异。

由此可见,在老年人中,体位性低血压的存在与认知能力下降无关。此外,在潜在的脑血管机制中也没有发现差异。

原始出处:


Foster-Dingley,et al. Orthostatic hypotension in older persons is not associated with cognitive functioning, features of cerebral damage or cerebral blood flow.Journal of Hypertension. 2018. https://journals.lww.com/jhypertension/Abstract/publishahead/Orthostatic_hypotension_in_older_persons_is_not.97530.aspx

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    2018-01-29 120e71dcm28暂无昵称

    学习了

    0

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likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/17/0ed05bbc4eb124766d2a39104932ec4e.jpg, createdBy=5afd2091871, createdName=情途末路, createdTime=Sat Jan 27 09:40:55 CST 2018, time=2018-01-27, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1810466, encodeId=5ab01810466c9, content=<a href='/topic/show?id=d5f48508569' target=_blank style='color:#2F92EE;'>#脑血流特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85085, encryptionId=d5f48508569, topicName=脑血流特征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Sun Aug 26 18:15:00 CST 2018, time=2018-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727018, encodeId=b42d1e2701894, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, 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encryptionId=754b8508329, topicName=脑血流)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b191324, createdName=marongnuan, createdTime=Tue Nov 20 18:15:00 CST 2018, time=2018-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283144, encodeId=3599283144f9, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b4b12216028, createdName=120e71dcm28暂无昵称, createdTime=Mon Jan 29 09:28:21 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1367361, encodeId=7a52136e3613e, content=<a href='/topic/show?id=f4012634656' target=_blank style='color:#2F92EE;'>#低血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26346, encryptionId=f4012634656, 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authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLS3nbTc0lzBwDxSVnm5KA9vNmsZrjTSvKlld6teMf4RG4ZmZWRvC80GB7zl4TSib3BAoZgcCYpzxQ/132, createdBy=02681961038, createdName=若轩, createdTime=Sat Jan 27 10:19:06 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282494, encodeId=cddf282494e9, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Jan 27 09:50:45 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282490, encodeId=6006282490f0, content=学习了.获益匪浅!感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/17/0ed05bbc4eb124766d2a39104932ec4e.jpg, createdBy=5afd2091871, createdName=情途末路, createdTime=Sat Jan 27 09:40:55 CST 2018, time=2018-01-27, status=1, ipAttribution=)]
    2018-01-27 若轩

    学习了

    0

  9. 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likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/17/0ed05bbc4eb124766d2a39104932ec4e.jpg, createdBy=5afd2091871, createdName=情途末路, createdTime=Sat Jan 27 09:40:55 CST 2018, time=2018-01-27, status=1, ipAttribution=)]
    2018-01-27 龙胆草

    学习谢谢分享

    0

  10. 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likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/17/0ed05bbc4eb124766d2a39104932ec4e.jpg, createdBy=5afd2091871, createdName=情途末路, createdTime=Sat Jan 27 09:40:55 CST 2018, time=2018-01-27, status=1, ipAttribution=)]
    2018-01-27 情途末路

    学习了.获益匪浅!感谢分享

    0

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由此可见,蛋白尿是老年人AD和VaD发生发展的重要危险因素。此外,蛋白尿和低eGFR与VaD更大的风险相关。

容易被忽视的老年人疾病——甲减

甲状腺功能减退症(简称甲减,hypothyroidism)系甲状腺激素合成分泌不足或生理效应不足所致的全身性疾病,可发生于任何年龄,老年人更是多见。文献报告年龄>65岁的老年人中,临床甲减的患病率约为1%~5%,另有5%~15%的人群伴亚临床性甲减,其患病率随年龄增长而增高,住院病人中患病率更高。 病史: 患者为一69岁老年女性,既往检查发现“冠状动脉粥样硬化性心脏病”病史约1年,未系统治