JAHA:年轻人肺功能与心血管事件风险

2018-12-10 xing.T MedSci原创

由此可见,年轻成人肺功能与中年心血管事件独立相关。这种关联似乎是由心力衰竭和脑血管事件占主导,而不是由冠心病引起的。

年轻成人肺功能峰值降低是未来慢性阻塞性肺病的危险因素。肺疾病与老年血管疾病之间的关系已有详细记载。年轻成人的肺功能峰值是否与未来血管事件的风险相关仍是未知的。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,年轻成人冠状动脉风险发展(CARDIA)研究是一项前瞻性、多中心、基于社区的纵向队列研究,该研究纳入了4761名年龄在18至30岁之间进行肺功能检测的参与者,研究人员调查了年轻成人肺部健康与随后的心血管事件风险之间的关系,并进行了Cox比例风险回归以评估基线、10年和20年肺功能与心血管事件之间的关联。研究人员进行线性和Logistic回归以探讨肺功能与心血管疾病危险因素以及颈动脉内膜中层厚度和冠状动脉钙化斑块发生发展之间的关系。

在基线时,参与者平均年龄(±SD)为24.9±3.6岁。基线时1秒用力呼气量比1秒内预测用力呼气量每降低10个百分比(风险比为1.18; 95%CI为1.06-1.31 [P=0.002])和FVC比预测FVC每降低10个百分比(风险比为1.19; 95%CI为1.06-1.33 [P=0.003])与未来的心血管事件相关,且与传统的心血管危险因素无关。基线肺功能与心力衰竭和脑血管事件有关,但与冠状动脉疾病事件无关。

由此可见,年轻成人肺功能与中年心血管事件独立相关。这种关联似乎是由心力衰竭和脑血管事件占主导,而不是由冠心病引起的。

原始出处:

Michael J. Cuttica,et al. Lung Function in Young Adults and Risk of Cardiovascular Events Over 29 Years: The CARDIA Study.JAHA.2018.https://www.ahajournals.org/doi/10.1161/JAHA.118.010672

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    2018-12-12 zhaohui6731
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    2018-12-11 1ddf0692m34(暂无匿称)

    学习了,谢谢分享

    0

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    2018-12-10 医者仁心5538

    学习了

    0

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