J Clin Oncol:年轻的癌症幸存者的心理健康问题不容忽视!

2021-01-29 MedSci原创 MedSci原创

年轻人患癌后,经过辛苦的抗癌治疗,幸存下来后精神心理方面会遗留多大的阴影呢?

青少年和青壮年(AYA)癌症幸存者的长期心理健康结果的风险和预测因素尚未有很好的归纳。因此,在这类人群的长期随访过程中往往忽视了心理健康。

Riddhita等利用基于人群的数据库筛选了加拿大安大略省在1992-2012年间被诊断为六种常见癌症之一的所有15-21岁的AYA的人群,并与匹配的对照组进行了比较。与各省医疗保健数据相联系,可以分析门诊(家庭医生和精神病学家)就诊率和严重精神事件(急诊室就诊、住院和自杀)的时间。此外,还研究了人口统计学、疾病和治疗相关的不良预后预测因子,包括治疗环境(成人 vs 儿科)。

心理健康问题就诊的累积次数

在2208名癌症幸存者和10457名匹配的对照中,5年癌症幸存者经历了比对照组更高的门诊精神卫生就诊率(671 vs 506次/1000人·年;调整后的比率比[RR] 1.3;95% CI 1.1-1.5;p=0.006)

严重精神疾病的累积发生率

癌症幸存者发生严重精神疾病的风险也增加了(调整后的风险比[HR] 1.2;95% CI 1.1-1.4,p=0.008)。虽然绝对风险仍然很低(15年累积发病率 1.7%;95% CI 1.0-2.7),但癌症幸存者发生精神障碍相关严重事件的风险增加了一倍(HR 2.0,95% CI 1.3-2.4;p=0.007)

在多变量分析中,在成人中心接受治疗的癌症幸存者与在儿科接受治疗的个体相比,有显著更高的门诊就诊率(RR 1.8;95% CI 1.0-3.1;p=0.04)。

综上所述,青少年和青壮年癌症幸存者的不良心理健康预后的风险显著增加,尤其是那些在成人中心接受治疗的患者。虽然绝对发病率仍很低,但癌症幸存者发生精神障碍相关严重事件的风险明显增加。有必要对这类人群进行长期的心理健康监测;对癌症治疗期间或治疗后的有效干预进行研究也是必要的。

原始出处:

De Riddhita,Sutradhar Rinku,Kurdyak Paul et al. Incidence and Predictors of Mental Health Outcomes Among Survivors of Adolescent and Young Adult Cancer: A Population-Based Study Using the IMPACT Cohort. J Clin Oncol, 2021, undefined: JCO2002019.

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    2021-04-30 MedSciZeng

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    2021-10-02 minlingfeng
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    2021-01-29 anti-cancer

    谢谢梅斯分享这么多精彩信息

    0

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    2021-01-29 ms1000001998897902

    感谢分享 受教

    0

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