膝关节炎痛痛痛!吃葡糖胺+硫酸软骨素+透明质酸补充剂靠谱吗?

2021-10-25 MedSci原创 MedSci原创

MEDICINE:透明质酸、葡萄糖胺和软骨素的液体组合作为膝关节骨性关节炎患者中度膝关节疼痛的膳食补充剂,疗效如何?

膝骨关节炎 (OA) 是成人人群中最常见的关节疾病。2010年,全球流行率为3.8%,并随着龄的增长而上升。除了年龄,性别,超重,肥胖和膝关节受伤史也是已知的膝OA的危险因素。目前,建议将非药物(运动、减肥、物理治疗或使用助行器或生物力学干预)和药物治疗(口服镇痛、非类固醇抗炎药物或带皮质类固醇或透明质激素[HA]的关节内注射)结合起来,以最佳方式管理膝骨关节炎。

膝OA的特点是关节软骨,特别是负重区的逐渐分解。因此,HA,葡萄糖胺和硫酸软骨素被广泛用作改善膝0A的膳食补充剂。研究人员对其功效和安全性进行了大力研究。包括54项研究在内的荟萃指,与安慰剂相比,葡萄糖胺与软骨素结合可显著减轻疼痛,改善膝OA患者的功能。基于上述发现,本研究旨在探索含有葡萄糖胺、硫酸软骨素和低分子量HA的补充混合物的口服液对有症状的膝OA患者的作用。

这是一个短期的,随机的,双盲的,安慰剂对照的研究。受试者被分配一瓶20mL补充混合物(50毫克HA加750毫克葡萄糖胺加250毫克软骨素,即A +HA)或安慰剂每天一次,持续8周。结果指标包括膝盖损伤和骨关节炎结果评分、西安大略省和麦克马斯特大学骨关节炎指数、36项短期表格调查(SF-36)、中国版匹兹堡睡眠质量指数以及不良事件发生率,并在第8周末进行评估。在修改后的治疗意向人群中,80名受试者中,39名接受A +HA,41名接受安慰剂。

大多数受试者是女性(75%),平均年龄为59.6岁,平均体重指数为25.2kg/m2。疼痛的平均值(标准偏差)视觉模拟量表为A +HA组的5.3(1.92)和安慰剂组的5.3(1.99)。基线人口和临床特征在群体之间很平衡,没有显著差异(表1)。

治疗8周后,A +HA组和安慰剂组的疼痛KOOS维度评分分别增加4.4(16.4)和6.4(16.4),症状分别增加8.0(15.8)和8.6 (19.1),ADL分别增加7.3(18.0)和7.2(16.2),生活质量分别增加8.5(17.0)和6.8(14.0)。组间KOOS差异无统计学意义(表2)。

对于次要疗效终点,治疗8周后,A+HA组和安慰剂组疼痛的WOMAC亚量表评分分别改善3.0(16.5)和7.2(17.1),僵硬度评分改善9.5(20.7)和12.8(27.9),功能评分改善7.3(18.0)和7.2(16.2)。SF-36量表的生理功能评分分别提高11.4(25.1)和5.4(24.2),身体健康导致的角色限制评分分别提高27.3(55.7)和10.8(48.4),身体疼痛评分分别提高10.1(21.8)和6.2(22.1),总体健康评分分别提高6.5(16.0)和3.6(16.4),活力评分分别提高3.6(15.3)和5.5 (19.2),治疗8周后,A +HA组和安慰剂组的社交功能分别改善3.0(14.7)和1.7(19.8),情绪问题导致的角色限制分别改善21.2(51.9)和3.6(52.0),而心理健康降低(15.8)和4.8(15.7)。

治疗8周后,CPSQI的7个成分评分与基线相比变化不大。A+HA组和安慰剂组CPSQI总分分别下降0.2(3.0)和0.6(3.0)。各组间WOMAC、SF-36、CPSQI差异均无统计学意义(表2)。

在安全性方面,22例(27.2%)受试者出现至少1例AE (A +HA组12例[30.8%],安慰剂组10例[23.8%]),经研究者判断均与治疗无关。上腹痛是两组中最常见的AE (A +HA组2例[5.1%],安慰剂组2例[4.8%])。

综上所述,这是首次探索膳食液体补充剂在膝盖OA治疗中结合HA、葡萄糖胺和软骨素的有效性和安全性的研究。本研究发现,短期使用HA、葡萄糖胺和软骨素组合口服液在目前的研究剂量中并未能有效改善膝OA疼痛和症状。

 

原文来源:

Shyu-Jye Wang, et al.Liquid combination of hyaluronan, glucosamine,and chondroitin as a dietary supplement for knee osteoarthritis patients with moderate knee pain. Medicine (2021) 100:40

http://dx.doi.org/10.1097/MD.0000000000027405

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    2021-11-28 WL

    吃氨基葡萄糖没有效果的意思吗?

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1756695, encodeId=a2f11e5669514, content=<a href='/topic/show?id=ba8e99e857c' target=_blank style='color:#2F92EE;'>#靠谱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99785, encryptionId=ba8e99e857c, topicName=靠谱)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=199a37204836, createdName=ms117281293605716, createdTime=Thu Dec 23 18:05:04 CST 2021, time=2021-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019867, encodeId=7518201986ea0, content=<a href='/topic/show?id=90f18822979' target=_blank style='color:#2F92EE;'>#葡糖胺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88229, encryptionId=90f18822979, topicName=葡糖胺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Tue Jan 18 13:05:04 CST 2022, time=2022-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074678, encodeId=21ba10e46780d, content=吃氨基葡萄糖没有效果的意思吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200810/413f8b33b4e34dcd82cbfc3ffd0f8c3c/4393e48ea913472084d5677670d3b48b.jpg, createdBy=b52c5409947, createdName=WL, createdTime=Sun Nov 28 07:08:17 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266333, encodeId=c5b0126633341, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Tue Oct 26 12:05:04 CST 2021, time=2021-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276753, encodeId=deb912e675377, content=<a href='/topic/show?id=ec9e9482383' target=_blank style='color:#2F92EE;'>#透明质酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94823, encryptionId=ec9e9482383, topicName=透明质酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Tue Oct 26 12:05:04 CST 2021, time=2021-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521538, encodeId=014b1521538d2, content=<a href='/topic/show?id=17a38586839' target=_blank style='color:#2F92EE;'>#膝关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85868, encryptionId=17a38586839, topicName=膝关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e3311361699, createdName=jiafufeng@yaho, createdTime=Tue Oct 26 12:05:04 CST 2021, time=2021-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1063814, encodeId=f034106381435, content=可信度太低!本人临床治疗效还是可以的,塞来昔布+盐酸氨基葡萄糖胶囊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211012/2205cdd463ef4633b0bf137f89667579/5c1f1a13cc6c427f9c26d3eba8230aae.jpg, createdBy=1ae32880011, createdName=业辉, createdTime=Mon Oct 25 17:05:39 CST 2021, time=2021-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1063697, encodeId=358b106369e51, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210612/ae1f02248c9641b28800bbf70c533b4e/dac9d7b3da4a48cea95d45f3342e39ed.jpg, createdBy=44d42480243, createdName=同(T_T)同, createdTime=Mon Oct 25 10:00:14 CST 2021, time=2021-10-25, status=1, ipAttribution=)]
    2021-10-26 lmm397
  5. [GetPortalCommentsPageByObjectIdResponse(id=1756695, encodeId=a2f11e5669514, content=<a href='/topic/show?id=ba8e99e857c' target=_blank style='color:#2F92EE;'>#靠谱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99785, encryptionId=ba8e99e857c, topicName=靠谱)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=199a37204836, createdName=ms117281293605716, createdTime=Thu Dec 23 18:05:04 CST 2021, time=2021-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019867, encodeId=7518201986ea0, content=<a href='/topic/show?id=90f18822979' target=_blank style='color:#2F92EE;'>#葡糖胺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88229, encryptionId=90f18822979, topicName=葡糖胺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Tue Jan 18 13:05:04 CST 2022, time=2022-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074678, encodeId=21ba10e46780d, content=吃氨基葡萄糖没有效果的意思吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200810/413f8b33b4e34dcd82cbfc3ffd0f8c3c/4393e48ea913472084d5677670d3b48b.jpg, createdBy=b52c5409947, createdName=WL, createdTime=Sun Nov 28 07:08:17 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266333, encodeId=c5b0126633341, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Tue Oct 26 12:05:04 CST 2021, time=2021-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276753, encodeId=deb912e675377, content=<a href='/topic/show?id=ec9e9482383' target=_blank style='color:#2F92EE;'>#透明质酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94823, encryptionId=ec9e9482383, topicName=透明质酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Tue Oct 26 12:05:04 CST 2021, time=2021-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521538, encodeId=014b1521538d2, content=<a href='/topic/show?id=17a38586839' target=_blank style='color:#2F92EE;'>#膝关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85868, encryptionId=17a38586839, topicName=膝关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e3311361699, createdName=jiafufeng@yaho, createdTime=Tue Oct 26 12:05:04 CST 2021, time=2021-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1063814, encodeId=f034106381435, content=可信度太低!本人临床治疗效还是可以的,塞来昔布+盐酸氨基葡萄糖胶囊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211012/2205cdd463ef4633b0bf137f89667579/5c1f1a13cc6c427f9c26d3eba8230aae.jpg, createdBy=1ae32880011, createdName=业辉, createdTime=Mon Oct 25 17:05:39 CST 2021, time=2021-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1063697, encodeId=358b106369e51, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210612/ae1f02248c9641b28800bbf70c533b4e/dac9d7b3da4a48cea95d45f3342e39ed.jpg, createdBy=44d42480243, createdName=同(T_T)同, createdTime=Mon Oct 25 10:00:14 CST 2021, time=2021-10-25, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1756695, encodeId=a2f11e5669514, content=<a href='/topic/show?id=ba8e99e857c' target=_blank style='color:#2F92EE;'>#靠谱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99785, encryptionId=ba8e99e857c, topicName=靠谱)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=199a37204836, createdName=ms117281293605716, createdTime=Thu Dec 23 18:05:04 CST 2021, time=2021-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019867, encodeId=7518201986ea0, content=<a href='/topic/show?id=90f18822979' target=_blank style='color:#2F92EE;'>#葡糖胺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88229, encryptionId=90f18822979, topicName=葡糖胺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Tue Jan 18 13:05:04 CST 2022, time=2022-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074678, encodeId=21ba10e46780d, content=吃氨基葡萄糖没有效果的意思吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200810/413f8b33b4e34dcd82cbfc3ffd0f8c3c/4393e48ea913472084d5677670d3b48b.jpg, createdBy=b52c5409947, createdName=WL, createdTime=Sun Nov 28 07:08:17 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266333, encodeId=c5b0126633341, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Tue Oct 26 12:05:04 CST 2021, time=2021-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276753, encodeId=deb912e675377, content=<a href='/topic/show?id=ec9e9482383' target=_blank style='color:#2F92EE;'>#透明质酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94823, encryptionId=ec9e9482383, topicName=透明质酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Tue Oct 26 12:05:04 CST 2021, time=2021-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521538, encodeId=014b1521538d2, content=<a href='/topic/show?id=17a38586839' target=_blank style='color:#2F92EE;'>#膝关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85868, encryptionId=17a38586839, topicName=膝关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e3311361699, createdName=jiafufeng@yaho, createdTime=Tue Oct 26 12:05:04 CST 2021, time=2021-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1063814, encodeId=f034106381435, content=可信度太低!本人临床治疗效还是可以的,塞来昔布+盐酸氨基葡萄糖胶囊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211012/2205cdd463ef4633b0bf137f89667579/5c1f1a13cc6c427f9c26d3eba8230aae.jpg, createdBy=1ae32880011, createdName=业辉, createdTime=Mon Oct 25 17:05:39 CST 2021, time=2021-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1063697, encodeId=358b106369e51, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210612/ae1f02248c9641b28800bbf70c533b4e/dac9d7b3da4a48cea95d45f3342e39ed.jpg, createdBy=44d42480243, createdName=同(T_T)同, createdTime=Mon Oct 25 10:00:14 CST 2021, time=2021-10-25, status=1, ipAttribution=)]
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    2021-10-25 业辉

    可信度太低!本人临床治疗效还是可以的,塞来昔布+盐酸氨基葡萄糖胶囊!

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1756695, encodeId=a2f11e5669514, content=<a href='/topic/show?id=ba8e99e857c' target=_blank style='color:#2F92EE;'>#靠谱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99785, encryptionId=ba8e99e857c, topicName=靠谱)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=199a37204836, createdName=ms117281293605716, createdTime=Thu Dec 23 18:05:04 CST 2021, time=2021-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019867, encodeId=7518201986ea0, content=<a href='/topic/show?id=90f18822979' target=_blank style='color:#2F92EE;'>#葡糖胺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88229, encryptionId=90f18822979, topicName=葡糖胺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Tue Jan 18 13:05:04 CST 2022, time=2022-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1074678, encodeId=21ba10e46780d, content=吃氨基葡萄糖没有效果的意思吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200810/413f8b33b4e34dcd82cbfc3ffd0f8c3c/4393e48ea913472084d5677670d3b48b.jpg, createdBy=b52c5409947, createdName=WL, createdTime=Sun Nov 28 07:08:17 CST 2021, time=2021-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266333, encodeId=c5b0126633341, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Tue Oct 26 12:05:04 CST 2021, time=2021-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276753, encodeId=deb912e675377, content=<a href='/topic/show?id=ec9e9482383' target=_blank style='color:#2F92EE;'>#透明质酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94823, encryptionId=ec9e9482383, topicName=透明质酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Tue Oct 26 12:05:04 CST 2021, time=2021-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521538, encodeId=014b1521538d2, content=<a href='/topic/show?id=17a38586839' target=_blank style='color:#2F92EE;'>#膝关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85868, encryptionId=17a38586839, topicName=膝关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e3311361699, createdName=jiafufeng@yaho, createdTime=Tue Oct 26 12:05:04 CST 2021, time=2021-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1063814, encodeId=f034106381435, content=可信度太低!本人临床治疗效还是可以的,塞来昔布+盐酸氨基葡萄糖胶囊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211012/2205cdd463ef4633b0bf137f89667579/5c1f1a13cc6c427f9c26d3eba8230aae.jpg, createdBy=1ae32880011, createdName=业辉, createdTime=Mon Oct 25 17:05:39 CST 2021, time=2021-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1063697, encodeId=358b106369e51, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210612/ae1f02248c9641b28800bbf70c533b4e/dac9d7b3da4a48cea95d45f3342e39ed.jpg, createdBy=44d42480243, createdName=同(T_T)同, createdTime=Mon Oct 25 10:00:14 CST 2021, time=2021-10-25, status=1, ipAttribution=)]
    2021-10-25 同(T_T)同

    学习了

    0

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