Am Heart J:BNP 5-32可作为急性心梗危险分层的二级标志物

2018-03-05 MedSci MedSci原创

B型钠尿肽(BNP)是急性心梗危险分层的一个标志物,近期,BNP的截断蛋白分子被发现,但其作为心梗危险分层的功能尚未阐明。本研究的目的旨在评估BNP的截断蛋白分子在心梗危险分层中的作用。本研究纳入了1078名急性心梗患者,对其血浆的BNP 5-32, BNP 4-32和BNP 3-32水平进行检测,并且随访观察患者的短期和长期预后。结果分析发现,BNP的截断蛋白分子水平是患者6个月、1年和2年发生

B型钠尿肽(BNP)是急性心梗危险分层的一个标志物,近期,BNP的截断蛋白分子被发现,但其作为心梗危险分层的功能尚未阐明。本研究的目的旨在评估BNP的截断蛋白分子在心梗危险分层中的作用。

本研究纳入了1078名急性心梗患者,对其血浆的BNP 5-32, BNP 4-32和BNP 3-32水平进行检测,并且随访观察患者的短期和长期预后。结果分析发现,BNP的截断蛋白分子水平是患者6个月、1年和2年发生死亡/心肌梗死心衰源性死亡/再住院和复合心血管不良事件的独立预测因子,并且与传统的BNP预测效果相当。重新分类分析后发现,BNP的截断蛋白分子联合GRACE临床危险评分可以成功对心梗患者的危险重新分层(P ≤ 0.005)。

研究结果显示,BNP的截断蛋白分子水平与急性心梗患者的不良预后相关,BNP 5-32可联合NT-proBNP作为危险分层的二级标志物。

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    2018-03-07 huiwelcome
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    2018-03-07 zhaojie88
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    2018-03-07 slcumt
  7. [GetPortalCommentsPageByObjectIdResponse(id=1720517, encodeId=2e221e20517cc, content=<a href='/topic/show?id=09bf36e741d' target=_blank style='color:#2F92EE;'>#危险分层#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36774, encryptionId=09bf36e741d, topicName=危险分层)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d5032846700, createdName=tidiq, createdTime=Mon May 07 18:27:00 CST 2018, time=2018-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841200, encodeId=0c561841200b7, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Wed May 09 10:27:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289309, encodeId=1e1f128930919, content=<a href='/topic/show?id=ede136018b' target=_blank style='color:#2F92EE;'>#BNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3601, encryptionId=ede136018b, topicName=BNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Wed Mar 07 06:27:00 CST 2018, time=2018-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308367, encodeId=256a130836e9b, content=<a href='/topic/show?id=8323522e503' target=_blank style='color:#2F92EE;'>#急性心梗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52275, encryptionId=8323522e503, topicName=急性心梗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa4f352, createdName=chenlianhui, createdTime=Wed Mar 07 06:27:00 CST 2018, time=2018-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356724, encodeId=ea221356e249e, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Mar 07 06:27:00 CST 2018, time=2018-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562866, encodeId=17b0156286662, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Wed Mar 07 06:27:00 CST 2018, time=2018-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293631, encodeId=2897293631d7, content=学习了.涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Mar 06 20:06:33 CST 2018, time=2018-03-06, status=1, ipAttribution=)]
    2018-03-06 虈亣靌

    学习了.涨知识了!

    0

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