CELL:人类肠道微生物组对药物代谢的个性化图谱绘制 

2020-06-11 MedSci原创 MedSci原创

人类肠道微生物群落拥有数百种具有不同生化能力的细菌物种。数十种药物已经被证明可以被肠道微生物组的单个菌株代谢,但这种现象的程度很少在微生物群落的背景下进行探索。

人类肠道微生物群落拥有数百种具有不同生化能力的细菌物种。数十种药物已经被证明可以被肠道微生物组的单个菌株代谢,但这种现象的程度很少在微生物群落的背景下进行探索。

在此,研究人员开发了一个定量实验框架,用于绘制人类肠道微生物组代谢小分子药物的能力:微生物衍生代谢物(MDM)-筛选。其包括一个用于个体特异性肠道微生物群落持续生长的批量培养系统,一个体外药物代谢筛查,以及靶向和非靶向功能元组学筛查,以确定负责特定代谢事件的微生物组编码基因。

该框架确定了个体之间不同的新型药物-微生物组相互作用,并展示了肠道微生物组如何用于药物开发和个性化医疗。

 

原始出处:

Bahar Javdan et al. Personalized Mapping of Drug Metabolism by the Human Gut Microbiome. CELL (2020). DOI:https://doi.org/10.1016/j.cell.2020.05.001

 

 

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    2021-04-25 维他命
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